Another angiotensin converting enzyme inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow depression, rarely in uncomplicated patients but more frequently in patients with renal impairment, especially if they also have a collagen vascular disease. Available data from clinical trials of Pressitan are insufficient to show that Pressitan does not cause agranulocytosis at similar rates. Marketing experience has revealed cases of neutropenia or agranulocytosis in which a causal relationship to Pressitan cannot be excluded. Periodic monitoring of white blood cell counts in patients with collagen vascular disease and renal disease should be considered.
Innovace, Innoz >About Pressitan
More common side effects
The more common side effects that can occur with Pressitan include:
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to Pressitan. Your doctor may order certain lab tests to check your body's response to Pressitan.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Hypersensitivity to Pressitan/other ACE inhibitors
History of ACE inhibitor-induced angioedema, hereditary or idiopathic angioedema
Pregnancy (2nd and 3rd trimesters): Significant risk of fetal and neonatal morbidity and mortality
Do not co-administer with aliskiren in patients with diabetes mellitus or with renal impairment (i.e., GFR less than 60 mL/min/1.73 m²)
¿Cuál es la información más importante que debo saber sobre Pressitan?
No use si usted está embarazada. Si queda embarazada, deje de tomar esta medicina y dígale a su médico de inmediato.
Usted no debe usar Pressitan si usted alguna vez ha tenido angioedema. No tome Pressitan durante las 36 horas antes o después de tomar medicina que contiene sacubatril (como Entresto).
Si usted tiene diabetes, no use Pressitan junto con ningún medicamento que contenga aliskiren (como Tekturna o Tekamlo).
Dosage Adjustment In Hypertensive Patients With Renal Impairment
The usual dose of Pressitan is recommended for patients with a creatinine clearance more than 30 mL/min (serum creatinine of up to approximately 3 mg/dL). For patients with creatinine clearance less than or equal to 30 mL/min (serum creatinine more than or equal to 3 mg/dL), the first dose is 2.5 mg once daily. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily.
Warnings for people with certain health conditions
For people with swelling (angioedema): If you have swelling throughout your body, this drug can make it worse. If you have a history of swelling throughout your body, you shouldn’t take Pressitan.
For people with low blood pressure: Pressitan can make your blood pressure lower. Tell your doctor if you already have low blood pressure. They may change your dose, especially if you have heart or kidney problems, or diabetes.
For people with heart problems: Use this drug with caution if you have ischemic heart disease. Pressitan may increase your risk of low blood pressure.
For people with moderate to severe kidney damage: Your doctor may lower your dosage of Pressitan.
For people who plan to have surgery or an anesthetic: You may experience low blood pressure while having major surgery or during anesthesia.
Heart and blood pressure drugs
Taking these medications with Pressitan can increase your risk of kidney problems, low blood pressure, and/or high blood potassium.
Examples of these drugs include:
- angiotensin-converting enzyme (ACE) inhibitors, such as: