Pranolol tablets

Pranolol

  • Active Ingredient: Propranolol
  • 80 mg, 40 mg, 20 mg
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What is Pranolol?

The active ingredient of Pranolol brand is propranolol. Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Propranolol Hydrochloride Extended-Release Capsules, USP, are formulated to provide a sustained release of Propranolol hydrochloride. Propranolol Hydrochloride Extended-Release Capsules, USP, are available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration. Each capsule for oral administration contains sugar spheres, ethylcellulose, hypromellose phthalate, povidone, diethyl phthalate, polyethylene glycol, titanium dioxide, ammonium hydroxide, potassium hydroxide, black iron oxide, and gelatin. The 80 mg, 120 mg, and 160 mg capsules contain red and yellow iron oxide. In addition, the 160 mg capsules contain FD&C Blue No. 2. These capsules comply with USP Dissolution Test 1. Propranolol Hydrochloride Extended-Release Capsules, USP, should not be considered a simple mg-for-mg substitute for conventional Propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see DOSAGE AND ADMINISTRATION). When changing to Propranolol Hydrochloride Extended-Release Capsules, USP, from conventional Propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Propranolol Hydrochloride Extended-Release Capsules, USP, have been therapeutically equivalent to the same mg dose of conventional Propranolol as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product. Effects of Propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, Propranolol also exerts a quinidine-like or anesthetic-like membrane action which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the anti-migraine effect of Propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain.

Used for

Pranolol is used to treat diseases such as: Angina, Anxiety, Aortic Stenosis, Arrhythmia, Atrial Fibrillation, Benign Essential Tremor, Heart Attack, Hemangioma, High Blood Pressure, Intermittent Explosive Disorder, Migraine Prevention, Mitral Valve Prolapse, Panic Disorder, Performance Anxiety, Pheochromocytoma, Portal Hypertension, Tardive Dyskinesia, Thyrotoxicosis, Ventricular Tachycardia.

Side Effect

Possible side effects of Pranolol include: Abdominal or stomach pain and tenderness; heartburn; peculiar postures or movements, mannerisms, or grimacing; trouble sleeping; difficulty with breathing; unusual dreams; cracks in the skin; irritability.

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Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Treatment with Pranolol can often be long-term. Continue to take the tablets/capsules unless your doctor tells you to stop. Stopping treatment suddenly can cause problems in some people, so your doctor may want you to reduce your dose gradually if this becomes necessary.
  • If you are due to have an operation or dental treatment, it is important to tell the person carrying out the treatment that you are taking a beta-blocker. This is because some anaesthetics may increase the risk of unwanted effects.
  • If you drink alcohol, ask your doctor for advice about taking Pranolol and alcohol. Alcohol will add to the blood pressure-lowering effect of Pranolol and so may not be recommended for you.
  • If you have diabetes, Pranolol can block the symptoms of low blood sugar. Your doctor will advise you about this.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take. Some medicines (including some cough, cold and flu remedies) may not be.
  • Your doctor may give you dietary and lifestyle advice about eating a healthy diet, not smoking, and taking regular exercise. If so, it is important that you follow the advice you are given.

DESCRIPTION

Inderal® (Pranolol hydrochloride) is a synthetic beta-adrenergic receptor blocking agent chemically described as 2-Propanol, 1--3-(1-naphthalenyloxy)-, hydrochloride,(±)-. Its molecular and structural formulae are:

Pranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

Inderal (Pranolol) is available as 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration.

The inactive ingredients contained in Inderal (Pranolol) Tablets are: lactose, magnesium stearate, microcrystalline cellulose, and stearic acid. In addition, Inderal (Pranolol) 10 mg and 80 mg Tablets contain FD&C Yellow No. 6 and D&C Yellow No. 10; Inderal (Pranolol) 20 mg Tablets contain FD&C Blue No. 1; Inderal (Pranolol) 40 mg Tablets contain FD&C Blue No. 1, FD&C Yellow No. 6, and D&C Yellow No. 10; Inderal (Pranolol) 60 mg Tablets contain D&C Red No. 30.

Common side effects

These common side effects happen in more than 1 in 100 people. They're usually mild and short lived.

Talk to your doctor or pharmacist if the side effects bother you or last more than a few days:

  • feeling tired, dizzy or light headed (these can be signs of a slow heart rate)
  • cold fingers or toes (Pranolol may affect the blood supply to your hands and feet)
  • difficulties sleeping or nightmares
  • feeling sick (nausea)

Drugs used to increase heart rate and blood pressure

Don’t use these medications with Pranolol. These drugs cancel one another out. This means that neither of them will work. Examples of these drugs include:

What Is Pranolol ( Vasostrict, ADH) and How Does It Work?

Pranolol is a beta-blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. It is also used to prevent migraine headaches and chest pain (angina). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Preventing chest pain can help improve your ability to exercise.

Pranolol works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This effect reduces heart rate, blood pressure, and strain on the heart.

Pranolol has also been used to control symptoms of anxiety or overactive thyroid (hyperthyroidism).

The oral formulation of Pranolol is used for infants and children to treat a certain benign tumor (proliferating infantile hemangioma). It helps to shrink the tumor.

Pranolol is available under the following different brand names: Inderal, Inderal LA, InnoPran XL, and Hemangeol.

Who Should Take Pranolol for Anxiety?

Pranolol is usually recommended to people who suffer from anxiety disorders to help relieve the symptoms. Studies on Pranolol have shown that the drug can effectively alleviate symptoms like uncontrolled trembling, blushing or shaking, increased heartbeat, fear of talking in front of a mass of people, muscle tension, sweating, and other symptoms associated with anxiety. However, it must be understood that the administration of Pranolol to relieve anxiety symptoms would be effective only in case of performance anxiety and stage fright. The effect of Pranolol in alleviating symptoms of other types of anxiety disorders is very low or even nil. Pranolol is only a temporary solution to the symptoms and cannot be considered as a treatment of the actual psychological condition.

Apart from treatment of anxiety symptoms, the drug is also prescribed to patients suffering from various diseases or ailments of the heart, respiratory disorders, aggressive behavior, phobia, etc. Irrespective of the condition for which Pranolol needs to be taken, a doctor’s prescription is necessary before you start a course of the drug.

Before taking Pranolol,

  • tell your doctor and pharmacist if you are allergic to Pranolol, any other medications, or any ingredients in Pranolol products. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: ACE inhibitors; antacids containing aluminum (Maalox, Mylanta, others); anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac, others), nicardipine (Cardene), nifedipine (Adalat, Procardia XL), and nisoldipine (Sular); cholestyramine (Prevalite); cimetidine; ciprofloxacin (Cipro); chlorpromazine; colestipol (Colestid); diazepam (Diastat, Valium); digoxin (Lanoxin); fluvoxamine (Luvox); haloperidol (Haldol); HMG-CoA reductase inhibitors (cholesterol-lowering agents) such as lovastatin (Altoprev, Mevacor, in Advicor) and pravastatin (Pravachol); isoniazid (in Rifamate, in Rifater); medications for depression such as bupropion (Aplenzin, Forfivo XL, Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem, Selfemra), imipramine (Tofranil), and paroxetine (Brisdelle, Paxil, Pexeva); fluconazole (Diflucan); medications for migraine headaches such as rizatriptan (Maxalt) and zolmitriptan (Zomig); medications for high blood pressure such as clonidine (Catapres, Kapvay, in Clorpres), doxazosin (Cardura), prazosin (Minipress), and terazosin; medications for seizures such as phenytoin (Dilantin, Phenytek) and phenobarbital; certain medications for irregular heartbeats such as amiodarone (Cordarone, Nexterone, Pacerone), propafenone (Rythmol), and quinidine (in Nuedexta); monoamine oxidase (MAO) inhibitors such as phenelzine (Nardil); montelukast (Singulair); nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (Indocin, Tivorbex); theophylline (Theo-24, Theochron, Uniphyl); reserpine; rifampin (Rifadin, Rimactane, in Rifater, in Rifamate); ritonavir (Norvir, in Kaletra, in Viekira Pak); teniposide (Vumon); thioridazine; ticlopidine; tolbutamide; tricyclic antidepressants; and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had asthma or other lung disease; heart, liver, or kidney disease; diabetes; severe allergies; or thyroid problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Pranolol, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Pranolol.
  • ask your doctor about the safe use of alcoholic beverages while you are taking Pranolol. Alcohol may increase the amount of Pranolol in your body.
  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

Allergy Information

Before taking any medication, including Pranolol, you should consider your allergies. By discussing your allergies with your medical providers or pharmacist, you can determine if Pranolol is a safe medication for you to use.

If you are allergic to Pranolol, there are a variety of symptoms you could experience. The most serious is an anaphylactic reaction during which you throat could swell; this reaction is rare. Some people who are allergic to Pranolol can get a rash, fever, sore throat, or shortness of breath. If you have had an allergic reaction to another beta-blocker, you may also experience an allergic reaction to Pranolol.

If you have had severe allergic reactions to other substances before, taking a beta-blocker can make you more reactive to those substances. It can also reduce your response to the treatment for these severe reactions. If you have experienced these serious types of allergies before, please talk to your primary care provider before starting a beta-blocker medication, such as Pranolol.


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