Platfree tablets

Platfree

  • Active Ingredient: Clopidogrel
  • 75 mg
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What is Platfree?

The active ingredient of Platfree brand is clopidogrel. Clopidogrel helps to prevent platelets in your blood from sticking together and forming a blood clot. Unwanted blood clots can occur with certain heart or blood vessel conditions. Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole. Effect of Clopidogrel on other drugs In vitro studies have shown that the glucuronide metabolite of Clopidogrel is a strong inhibitor of CYP2C8. Concomitant administration of repaglinide with Clopidogrel increased the systemic exposure to repaglinide (AUC0-∞) by 5.1-fold following the loading dose (300 mg) and by 3.9-fold on day 3 of the maintenance dose (75 mg) of Clopidogrel [see Drug Interactions (7.5)].

Used for

Platfree is used to treat diseases such as: Acute Coronary Syndrome, Acute Coronary Syndrome, Prophylaxis, Heart Attack, Ischemic Stroke, Ischemic Stroke, Prophylaxis, Percutaneous Coronary Intervention, Peripheral Arterial Disease, Platelet Aggregation Inhibition, Transient Ischemic Attack.

Side Effect

Possible side effects of Platfree include: vomiting of blood or material that looks like coffee grounds; swollen lymph glands; blistering, flaking, or peeling of the skin; swelling of the eyes, face, or inside of the nose; Bad, unusual, or unpleasant (after) taste.

How to Buy Platfree tablets online?

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Platfree side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Platfree increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.

Also call your doctor at once if you have:

pale skin, easy bruising, purple spots under your skin or in your mouth;

jaundice (yellowing of your skin or eyes);

fast heartbeats, shortness of breath;

headache, fever, weakness, feeling tired;

little or no urination;

signs of a blood clot--sudden numbness or weakness, confusion, problems with vision or speech.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Allergic reaction

In some cases Platfree can cause an allergic reaction. Go to the nearest hospital's accident and emergency department (A&E) if you experience:

  • swelling of the lips, mouth or throat
  • breathing problems
  • a skin rash that appears quickly

Mechanism Of Action

Platfree is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.

What you should do about this interaction:

While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice you should discuss with your doctor the effects of grapefruit on the blood levels of this medicine. These effects can occur even if grapefruit is not consumed at the same time of the Platfree dose This interaction may occur at any time in your treatment with Platfree if grapefruit or grapefruit juice is consumed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Grapefruit juice inhibits the metabolic activation of Platfree. Clin Pharmacol Ther 2014 Mar;95(3):307-13..

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Opioids

Taking an opioid medication with Platfree can delay the absorption and reduce the amount of Platfree in your body, making it less effective. If you must take these drugs together, your doctor may prescribe an additional medication to help prevent blood clots in certain situations.

Examples of opioids include:

The Platfree dosage your doctor prescribes will depend on the type of condition you’re using the drug to treat.

Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

El Platfree puede ocasionar efectos secundarios. Informe a su mГ©dico si cualquiera de estos sГ­ntomas es fuerte o no desaparece:

  • cansancio excesivo
  • dolor de cabeza
  • mareos
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  • vГіmitos
  • dolor de estГіmago
  • diarrea
  • sangrado de nariz
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Special cons >

Platfree may not be suitable to take if you have certain health conditions or are taking other medications.

7. Pregnancy and breastfeeding

Platfree isn't normally recommended in pregnancy or when breastfeeding.

If you're trying to get pregnant or are already pregnant, talk to your doctor about the possible benefits or harms of taking Platfree.

These will depend on how many weeks pregnant you are and the reason you need to take it. There may be other treatments that are safer for you.

Before taking this medicine

You should not use Platfree if you are allergic to it, or if you have:

any active bleeding; or

a stomach ulcer or bleeding in the brain (such as from a head injury).

Tell your doctor if you have ever had:

an ulcer in your stomach or intestines; or

a bleeding disorder or blood clotting disorder.

Platfree may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Platfree is right for you.

This medicine is not expected to harm an unborn baby. However, taking Platfree within 1 week before childbirth can cause bleeding in the mother. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Platfree is metabolized to its active metabolite in part by CYP2C19. Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of Platfree and a reduction in platelet inhibition.

Platfree and low-dose aspirin

Sometimes, you may be given both low-dose aspirin and Platfree. Taken together, they are very effective, but there is a higher risk of bleeding, usually in the gut. This risk increases with age. The key question for your doctor is whether the benefits outweigh the extra risk.

This combination treatment is prescribed for a limited period of time, usually up to a maximum of 12 months. After this period, your specialist will usually advise you to stop 1 of the 2 antiplatelet medications.

Q: My husband was put on Plavix 12 weeks ago after his first heart attack. I have been reading that it causes ulcers. Is it risky because of that ?

A: Plavix (Platfree) (//www.everydayhealth.com/drugs/plavix) is a platelet aggregation inhibitor that works by slowly or stopping platelets from sticking to blood vessels. Plavix reduces the risk of heart attacks and strokes for people who are already at risk and also helps with circulation problems caused by narrowing of the arteries. (//www.everydayhealth.com/stroke/guide/) (//www.everydayhealth.com/heart-health/). Common side effects of Plavix include bleeding and bruising. A search of prescribing information did not specifically list ulcers as an adverse effect of Plavix. This is not a complete list of side effects associated with Plavix. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals and herbals, as well as foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescriptions and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and advise you about drug interactions and side effects. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U.S Food and Drug Administration by visiting //www.fda.gov/Safety/MedWatch/default.htm or by calling 1-800-FDA-1088. Kimberly Hotz, PharmD

Q: Does cranberry juice interfere with Plavix?

A: Plavix (Platfree) hinders the platelets in the blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Plavix is used to prevent blood clots after a recent heart attack or stroke and in people with certain disorders of the heart or blood vessels. As a result of the action of this drug, Plavix can make it easier for bleeding to occur, even from a minor injury. There are no documented medical reports or research studies that have concluded that cranberry juice has any effect on Plavix. There have been some reports that cranberry juice should not be taken with Coumadin (warfarin), because it may lengthen the clotting time even further. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Gregory Latham, RPh

Q: Is the generic Plavix as effective as the original Plavix? How long should one be on Plavix?

A: Your question concerns Plavix (Platfree) (//www.everydayhealth.com/drugs/plavix). At the present time, there is no generic Platfree available in the United States. While antiplatelet therapy with medications such as Plavix is not usually permanent, it may last for weeks or even many months. It is always a good idea to check with one


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