Oposim tablets


  • Active Ingredient: Propranolol
  • 80 mg, 40 mg, 20 mg
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What is Oposim?

The active ingredient of Oposim brand is propranolol. Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Propranolol Hydrochloride Extended-Release Capsules, USP, are formulated to provide a sustained release of Propranolol hydrochloride. Propranolol Hydrochloride Extended-Release Capsules, USP, are available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration. Each capsule for oral administration contains sugar spheres, ethylcellulose, hypromellose phthalate, povidone, diethyl phthalate, polyethylene glycol, titanium dioxide, ammonium hydroxide, potassium hydroxide, black iron oxide, and gelatin. The 80 mg, 120 mg, and 160 mg capsules contain red and yellow iron oxide. In addition, the 160 mg capsules contain FD&C Blue No. 2. These capsules comply with USP Dissolution Test 1. Propranolol Hydrochloride Extended-Release Capsules, USP, should not be considered a simple mg-for-mg substitute for conventional Propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see DOSAGE AND ADMINISTRATION). When changing to Propranolol Hydrochloride Extended-Release Capsules, USP, from conventional Propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Propranolol Hydrochloride Extended-Release Capsules, USP, have been therapeutically equivalent to the same mg dose of conventional Propranolol as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product. Effects of Propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, Propranolol also exerts a quinidine-like or anesthetic-like membrane action which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the anti-migraine effect of Propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain.

Used for

Oposim is used to treat diseases such as: Angina, Anxiety, Aortic Stenosis, Arrhythmia, Atrial Fibrillation, Benign Essential Tremor, Heart Attack, Hemangioma, High Blood Pressure, Intermittent Explosive Disorder, Migraine Prevention, Mitral Valve Prolapse, Panic Disorder, Performance Anxiety, Pheochromocytoma, Portal Hypertension, Tardive Dyskinesia, Thyrotoxicosis, Ventricular Tachycardia.

Side Effect

Possible side effects of Oposim include: Abdominal or stomach pain and tenderness; lightheadedness, dizziness, or fainting; depersonalization; headaches; general feeling of discomfort, illness, or weakness.

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Oposim is listed as a pregnancy category C. While there are no well-controlled studies that have been done in pregnant women, there have been some deficits reported in mothers who were on Oposim during pregnancy. If you are on Oposim and become pregnant or are considering starting Oposim during pregnancy, discuss this with your medical provider. Together you can determine if the benefits outweigh the risks in your situation.

After giving birth, Oposim is excreted in breast milk and should be used with caution in nursing mothers.


Because of the variable bioavailability of Oposim, the dose should be individualized based on response.

How to take it

Oposim doesn't usually upset your tummy so you can take it with or without food. It's best to do the same each day.

Swallow the tablets whole with a drink of water. If you find them difficult to swallow, some brands have a score line to help you break the tablet in half. Check the information leaflet for your brand to see if you can do this.

If you're taking Oposim as a liquid, it will come with a plastic syringe or spoon to help you measure out the right dose. If you don't have one, ask your pharmacist for one. Don't use a kitchen teaspoon as it won't give you the right amount of medicine.

Before taking this medicine

You should not use Oposim if you are allergic to it, or if you have:

very slow heart beats that have caused you to faint; or

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker).

Babies who weigh less than 4.5 pounds should not be given Hemangeol oral liquid.

To make sure Oposim is safe for you, tell your doctor if you have:

a muscle disorder;

bronchitis, emphysema, or other breathing disorders;

low blood sugar, or diabetes (Oposim can make it harder for you to tell when you have low blood sugar);

slow heartbeats, low blood pressure;

congestive heart failure;

liver or kidney disease;

a thyroid disorder;

pheochromocytoma (tumor of the adrenal gland); or

problems with circulation (such as Raynaud's syndrome).

It is not known whether Oposim will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Oposim.

Oposim can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Typical Uses

Oposim is most widely used for heart conditions. It is one of the medications approved to lower blood pressure. It can control heart rate in people who have fast heart rhythms, such as atrial fibrillation or ventricular tachycardia. Many people also use Oposim to prevent migraines or reduce symptoms of tremors. The liquid formulation is also approved for infants who have proliferating infantile hemangioma.

3. Who can and can't take Oposim

Oposim can be taken by adults and children. But it is not officially approved for treating high blood pressure in children under 12 years old.

It isn't suitable for everyone. To make sure it is safe for you, tell your doctor before starting Oposim if you have:

  • had an allergic reaction to Oposim or any other medicine in the past
  • low blood pressure or a slow heart rate
  • heart failure which is getting worse
  • severe blood circulation problems in your limbs (such as Raynaud's phenomenon), which may make your fingers and toes tingle or turn pale or blue
  • metabolic acidosis - when there is too much acid in your blood
  • lung disease or asthma

Tell your doctor if you're trying to get pregnant, are already pregnant or if you're breastfeeding.

Drug to treat stomach ulcers

Taking cimetidine with Oposim can increase the levels of Oposim in your blood. This can cause more side effects.

7. Pregnancy and breastfeeding

Oposim isn't thought to be harmful during pregnancy, but it is not possible to be certain. So if you're trying to get pregnant or you're already pregnant, talk to your doctor about the benefits and possible harms of taking Oposim. There may be other medicines that are safer for you.

For more information about how Oposim can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website.

Oposim and breastfeeding

It is usually safe to take Oposim if you're breastfeeding. This is because only small amounts get into breast milk, which is not enough to cause any problems to your baby.

However, speak to your doctor before taking Oposim if your baby was premature or has any health problems.

Before Taking Oposim

Before taking Oposim for anxiety, it is important you talk about the medication with your physician and your mental health provider. They can help you determine if this medication is appropriate for you. For some medical conditions, Oposim is not a good medication to take. There are also some forms of anxiety that do not benefit from using Oposim.

For regular (short-acting) Oposim: Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 4 hours away. For extended-release Oposim (Inderal LA, InnoPran XL and others): Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 8 hours away. Do not take extra medicine to make up the missed dose.

How Can Oposim Help Me?

Oposim has been prescribed for anxiety for many years. It can be useful for different forms of anxiety, and its benefits depend on the symptoms you are trying to manage.

What is the dosage for Oposim?

The recommended dose for hypertension using short acting formulations is 80-240 mg twice daily. The maximum dose is 640 mg daily.

The usual dose using long acting formulations is 80-160 mg daily.

The recommended dose for chest pain is 80-320 mg daily using short acting formulations and 80-160 mg daily using long acting formulations.

The usual dose for treatment of abnormal heart rhythms is 10-30 mg 3-4 times daily of short acting formulations.

The recommended dose for preventing migraines is 80-240 mg daily.

Generic Name: Oposim (pro PRAN oh lol)Brand Names: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 9, 2018.

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