Nolarmin tablets

Nolarmin

  • Active Ingredient: Enalapril
  • 10 mg, 5 mg
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What is Nolarmin?

The active ingredient of Nolarmin brand is enalapril. Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. C20H28N2O5в€™C4H4O4 M.W. 492.53 Enalapril maleate, USP is an off-white, crystalline powder. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin converting enzyme inhibitor. Enalapril maleate tablets USP are supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition, each tablet contains the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium bicarbonate. Each 2.5 mg tablet contains D&C red #27 aluminum lake, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, and FD&C yellow #6 aluminum lake. Each 10 mg tablet contains FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake and FD&C yellow #6 aluminum lake. Each 20 mg tablet contains FD&C Yellow #6.

Used for

Nolarmin is used to treat diseases such as: Alport Syndrome, Diabetic Kidney Disease, Heart Failure, High Blood Pressure, Hypertensive Emergency, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Nolarmin include: dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; sweating; fever or chills; sore throat; tightness in the chest; sneezing; Lack or loss of strength; Chest pain.

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DESCRIPTION

VASOTEC® (Nolarmin Maleate) is the maleate salt of Nolarmin, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, Nolarminat. Nolarmin maleate is chemically described as (S)-1-L-alanyl]-L-proline, (Z)-2-butenedioate salt (1:1). Its empirical formula is C20H28N2O5•C4H4O4, and its structural formula is:

Nolarmin maleate is a white to off-white, crystalline powder with a molecular weight of 492.53. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol.

Nolarmin is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to Nolarminat, which is the active angiotensin converting enzyme inhibitor.

Nolarmin maleate is supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition to the active ingredient Nolarmin maleate, each tablet contains the following inactive ingredients: lactose, magnesium stearate, sodium bicarbonate, and starch. The 10 mg and 20 mg tablets also contain iron oxides.

Q: I started taking Nolarmin 10 mg for my blood pressure. But I am feeling kind of dizzy and I have blurry eyes. Is this normal? What can I do?

A: Nolarmin (Vasotec) is an ACE inhibitor used to treat high blood pressure and other heart conditions. Whenever starting a new blood pressure medication you may notice some dizziness especially upon standing. Be sure to stand slowly. If lying down first sit and then slowly stand when getting up. This should improve as your body gets used to having a lower blood pressure. If the dizziness is severe or does not get better, be sure to talk to your healthcare provider. Blood pressure could drop too low and a lower dose of Nolarmin (Vasotec) may be necessary. Blurry eyes may be related to the dizziness, if not be sure to tell your healthcare provider. Please see the following Everyday Health link for more information on Nolarmin (Vasotec). //www.everydayhealth.com/drugs/Nolarmin Laura Cable, PharmD

As with all vasodilators, Nolarmin should be given with caution to patients with obstruction in the outflow tract of the left ventricle.

How to use Nolarmin Maleate

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily.

If you are using the suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

For the treatment of high blood pressure, it may take several weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).

Hypotension

Excessive hypotension is rare in uncomplicated hypertensive patients treated with VASOTEC alone. Patients with heart failure given VASOTEC commonly have some reduction in blood pressure, especially with the first dose, but discontinuation of therapy for continuing symptomatic hypotension usually is not necessary when dosing instructions are followed; caution should be observed when initiating therapy (see DOSAGE AND ADMINISTRATION). Patients at risk for excessive hypotension, sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high-dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. It may be advisable to eliminate the diuretic (except in patients with heart failure), reduce the diuretic dose or increase salt intake cautiously before initiating therapy with VASOTEC in patients at risk for excessive hypotension who are able to tolerate such adjustments (see DRUG INTERACTIONS and ADVERSE REACTIONS). In patients at risk for excessive hypotension, therapy should be started under very close medical supervision and such patients should be followed closely for the first two weeks of treatment and whenever the dose of Nolarmin and/or diuretic is increased. Similar considerations may apply to patients with ischemic heart or cerebrovascular disease, in whom an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident.

If excessive hypotension occurs, the patient should be placed in the supine position and, if necessary, receive an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further doses of VASOTEC, which usually can be given without difficulty once the blood pressure has stabilized. If symptomatic hypotension develops, a dose reduction or discontinuation of VASOTEC or concomitant diuretic may be necessary.

Why it's used

Nolarmin oral tablet is used to treat high blood pressure, heart failure, and asymptomatic left ventricular dysfunction.

Nolarmin may be used as part of a combination therapy. That means you need to take it with other drugs.

Before taking Nolarmin,

  • tell your doctor and pharmacist if you are allergic to Nolarmin; other ACE inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril (Monopril), lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); any other medications; or any ingredients in Nolarmin tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor or pharmacist if you are taking valsartan and sacubitril (Entresto) or if you have stopped taking it within the last 36 hours. Your doctor will probably tell you not to take Nolarmin, if you are also taking valsartan and sacubitril. Also, tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, in Tekamlo, in Tekturna HCT). Your doctor will probably tell you not to take Nolarmin if you have diabetes and you are also taking aliskiren.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (Indocin, Tivorbex); diuretics ('water pills'); lithium (Lithobid); and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had heart or kidney disease; lupus; scleroderma (a condition in which extra tissue grows on the skin and some organs); diabetes; or angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs).
  • tell your doctor if you are breastfeeding.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Nolarmin.
  • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

What should I avoid while taking Nolarmin?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Nolarmin.

Do not use salt substitutes or potassium supplements while taking Nolarmin, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

6. How to cope with s >

What to do about:

  • dry, tickly cough - cough medicines don't usually help for coughs caused by Nolarmin. Sometimes the cough will get better on its own if you keep taking Nolarmin. Talk to your doctor if it carries on, bothers you or stops you from sleeping. Another medicine may suit you better. If your doctor recommends that you stop taking Nolarmin, the cough may take a few days to a month to go away.
  • feeling dizzy - if Nolarmin makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Don't drive or use tools or machines while you're feeling dizzy or shaky.
  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
  • diarrhoea - drink lots of fluids, such as water or squash, to avoid dehydration. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Don't take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • itching or a mild rash - it may help to take an antihistamine which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.
  • blurred vision - avoid driving or using tools or machines while this is happening. If it lasts for more than a day or two speak to your doctor as they may need to change your treatment.

How to take Nolarmin

  • Before you start the treatment, read the manufacturer's printed information leaflet from ins >

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