Noklot tablets

Noklot

  • Active Ingredient: Clopidogrel
  • 75 mg
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What is Noklot?

The active ingredient of Noklot brand is clopidogrel. Clopidogrel helps to prevent platelets in your blood from sticking together and forming a blood clot. Unwanted blood clots can occur with certain heart or blood vessel conditions. Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole. Effect of Clopidogrel on other drugs In vitro studies have shown that the glucuronide metabolite of Clopidogrel is a strong inhibitor of CYP2C8. Concomitant administration of repaglinide with Clopidogrel increased the systemic exposure to repaglinide (AUC0-∞) by 5.1-fold following the loading dose (300 mg) and by 3.9-fold on day 3 of the maintenance dose (75 mg) of Clopidogrel [see Drug Interactions (7.5)].

Used for

Noklot is used to treat diseases such as: Acute Coronary Syndrome, Acute Coronary Syndrome, Prophylaxis, Heart Attack, Ischemic Stroke, Ischemic Stroke, Prophylaxis, Percutaneous Coronary Intervention, Peripheral Arterial Disease, Platelet Aggregation Inhibition, Transient Ischemic Attack.

Side Effect

Possible side effects of Noklot include: puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; lower back or side pain; indigestion; nausea or vomiting; collection of blood under the skin.

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Which drugs or supplements interact with Noklot?

Combining Noklot with warfarin (Coumadin) or other drugs that cause bleeding increases the risk of bleeding.

Noklot is converted to its active form by enzymes in the liver. Drugs that reduce the activity of these enzymes, for example, omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium) may reduce the activity of Noklot and should not be used with Noklot. Other drugs that also may react with Noklot in a similar fashion include fluoxetine (Prozac, Sarafem), cimetidine (Tagamet), fluconazole (Diflucan), ketoconazole (Nizoral, Extina, Xolegel, Kuric), voriconazole (Vfend), ethaverine (Ethatab, Ethavex), felbamate (Felbatol), and fluvoxamine (Luvox).

Q: Can I take ranitidine with Plavix?

A: Plavix (Noklot) keeps the platelets in the blood from coagulating or clotting to prevent unwanted blood clots. Plavix is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels. Ranitidine (Zantac) belongs to a class of drugs called histamine-2 (H2) blockers that works by reducing the amount of acid the stomach produces. While some drugs in this H2 blocker class, such as cimetidine (Tagamet), can interfere with the clotting action of Plavix, rantidine does not. Ranitidine, famotidine (Pepcid), and antacids are not expected to interfere with the anti-clotting activity of Plavix. However, another class of acid reducers, the proton pump inhibitors (PPIs), should be avoided with Plavix. An example of a PPI is omeprazole (Prilosec). It's important to be aware of these interactions since many of these acid-reducing medications are available over-the-counter. Always read and follow the complete directions and warnings on over-the-counter medicines and discuss their use with your doctor before taking them. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD

Serious side effects

More serious side effects can include:

  • rashes and itching
  • severe stomach ache or abdominal pain
  • uncontrolled bleeding or unusual bruising
  • vomiting with blood
  • weakness or numbness in an arm or leg
  • blood in your urine (haematuria)
  • blood in your stools

Speak to your GP or call the NHS 24 111 service immediately if you experience any of these side effects or any other unusual problems while taking Noklot.

Q: I take Plavix and have GERD. Zantac 300 mg is no longer helping my heartburn. What can I take with Plavix?

A: Treating heartburn and GERD can be tricky in patients taking Plavix (Noklot) because of drug interactions with the medications used to treat those symptoms. H2 Blockers, the class of drugs that includes Zantac (ranitidine), are okay to use. The exception is cimetidine which will interact with Plavix. The other main class of drugs used to treat GERD is the proton pump inhibitors (PPIs). The FDA has released a safety bulletin about using omeprazole, a PPI, with Plavix. This combination results in decreased effectiveness of Plavix, increasing the risk of heart attack or stroke. It is unclear if the other PPI drugs have the same effect and if it is to the same extent. Over-the-counter (OTC) antacids, such as Tums, may help somewhat. Always read and follow the complete directions and warnings on OTC medications and discuss their use with your healthcare provider before taking them. Contact your healthcare provider to discuss your treatment options. You may also find helpful information at //www.everydayhealth.com/drugs/plavixSarah Lewis, PharmD

Q: Can Plavix or Aspirin affect healing associated with a tattoo?

A: Plavix (Noklot), which keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions, is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels. The most common side effects with Plavix are pruritus (intense itching sensation), purpura (bleeding under the skin), diarrhea, and rash. Aspirin, one of a group of drugs called salicylates, works by reducing substances in the body that cause pain, fever, and inflammation. Aspirin is used to treat mild to moderate pain, and also to reduce fever or inflammation. Aspirin is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor. The most common side effects with aspirin are nausea, dyspepsia (upset stomach), tinnitus (ringing or roaring in the ears) with large doses, and dizziness with large doses. The combination of Plavix and aspirin can increase the risk of further bleeding. This is not a complete list of the side effects associated with Plavix or aspirin. Gregory Latham, RPh

Q: What would the interaction be between Plavix and Nexium?

A: Plavix (Noklot bisulfate) is an oral antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Generally speaking, drug interactions fall into three main categories: Drug-drug (i.e., prescription, over-the-counter, herbals, dietary supplements) interactions occur when two or more drugs react with each other. Drug-diet (food/drink) interactions result from drugs reacting with foods or drinks. Drug-disease interactions may occur when an existing medical condition makes certain drugs potentially harmful. Coadministration with proton pump inhibitors (PPIs), such as Nexium (esomeprazole) may reduce the cardioprotective effects of Noklot. Until further data is available, the use of proton pump inhibitors should preferably be avoided in patients treated with Noklot. PPIs should only be considered in high-risk patients such as those receiving dual antiplatelet therapy, those with a history of gastrointestinal bleeding or ulcers, and those receiving concomitant anticoagulant therapy, and then only after thorough assessment of risks versus benefits. If gastroprotection is necessary, H2-receptor antagonists or antacids should be prescribed whenever possible. For more specific information, consult with your doctor or pharmacist for guidance based on your specific condition and current medications. Shereen A. Gharbia, PharmD

El Noklot puede ocasionar efectos secundarios. Informe a su mГ©dico si cualquiera de estos sГ­ntomas es fuerte o no desaparece:

  • cansancio excesivo
  • dolor de cabeza
  • mareos
  • nГЎusea
  • vГіmitos
  • dolor de estГіmago
  • diarrea
  • sangrado de nariz

There are no data on the presence of Noklot in human milk or the effects on milk production. No adverse effects on breastfed infants have been observed with maternal Noklot use during lactation in a small number of postmarketing cases. Studies in rats have shown that Noklot and/or its metabolites are present in the milk. When a drug is present in animal milk, it is likely that the drug will be present in human milk. The developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for PLAVIX and any potential adverse effects on the breastfed infant from PLAVIX or from underlying maternal condition.

How is this medicine (Noklot) best taken?

Use Noklot as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Keep taking Noklot as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses unless told to do so by your doctor.

What Is Noklot and How Does It Work?

Noklot is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).

Noklot works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.

Noklot is available under the following different brand names: Plavix.

Dosages of Noklot:

Dosage Forms and Strengths

Dosage Considerations – Should be Given as Follows:

Unstable angina, non-ST-segment elevation heart attack (myocardial infarction ) (NSTEMI): 300 mg loading dose; initiating therapy without a loading dose will delay establishment of antiplatelet effect by several days; following the loading dose, administer 75 mg/day orally for up to 12 months; may administer beyond 12 months if used in combination with aspirin (75-100 mg/day); long-term combination therapy with aspirin, following stent placement, is individualized depending on how a patient tolerates long-term dual antiplatelet therapy (DAPT), whether they have stable coronary artery disease, and do NOT have risk factors (e.g., transient ischemic attack or stroke, age over 75 years, bleeding risk, low body weight, concurrent medications)

ST-segment elevation myocardial infarction (MI) (STEMI): 75 mg/day orally in combination with aspirin 162-325 mg/day and then 81-162 mg/day

Age under 75 years

  • 300 mg loading dose followed by 75 mg for 14 days up to 12 months (if no bleeding)
  • Concomitant therapy with aspirin: Administer in combination with aspirin 75-325 mg once/day with or without thrombolytics

Age over 75 years

  • No loading dose
  • 75 mg for 14 days up to 12 months (if no bleeding)

Recent heart attack (Myocardial Infarction ), Stroke, or Established Peripheral Arterial Disease

  • 75 mg orally once/day without a loading dose; recommended as alternative to aspirin or concomitantly with aspirin if patient not at increased risk for bleeding but at high risk for cardiovascular disease

  • Prophylaxis if patient not candidate for oral anticoagulation
  • 75 mg/day orally

  • Renal impairment: Dose adjustment not necessary
  • Hepatic impairment: Use caution; experience limited

  • CYP2C19 poor metabolizers associated with diminished antiplatelet response to Noklot; although higher-dose regimen (600 mg loading dose followed by 150 mg once daily) in poor metabolizers increases antiplatelet response, no appropriate dosing regimen for poor metabolizers has been established in clinical outcome trials
  • Not recommended for pediatric use

Antes de tomar Noklot,

  • informe a su mГ©dico o farmacГ©utico si es alГ©rgico a Noklot, prasugrel (Effient), ticlopidina (Ticlid) o cualquier otro medicamento o a alguno de los ingredientes que contienen las tabletas de Noklot. Pregunte a su farmacГ©utico o revise la GuГ­a del medicamento para obtener una lista de ingredientes.
  • Informe a su mГ©dico y farmacГ©utico quГ© otros medicamentos con y sin receta mГ©dica, vitaminas, suplementos nutricionales y productos de hierbas estГЎ tomando o tiene planificado tomar. AsegГєrese de mencionar cualquiera de los siguientes: anticoagulantes ('diluyentes de la sangre') como warfarina (Coumadin, Jantoven); aspirina y otros antiinflamatorios no esteroides (AINE) como ibuprofeno (Advil, Motrin) y naxopreno (Aleve, Naprosyn); cilostazol; esomeprazol (Nexium); etravirina (Intelence); omeprazol (Prilosec, Prilosec OTC, Zegerid); repaglinida (Prandin, en Prandimet); inhibidores selectivos de la recaptaciГіn de la serotonina (SSRI, por sus siglas en inglГ©s) como citalopram (Celexa), escitalopram (Lexapro), fluoxetina (Prozac, Sarafem, en Symbyax), fluvoxamina (Luvox), paroxetina (Paxil), y sertralina (Zoloft); y inhibidores selectivos de la recaptaciГіn de la serotonina y la norepinefrina (SNRI, por sus siglas en inglГ©s) como desvenlafaxina (Khedezla, Pristiq), duloxetina (Cymbalta), sibutramina (ya no estГЎ disponible en EE. UU.; Meridia), y venlafaxina (Effexor). Es posible que su mГ©dico deba cambiar las dosis de sus medicamentos o supervisar atentamente si sufre efectos secundarios.
  • Informe a su mГ©dico si tiene Гєlceras sangrantes (llagas que sangran en el recubrimiento del estГіmago o el intestino delgado), sangrado en el cerebro o cualquier otra condiciГіn que cause sangrado profuso. Es posible que su mГ©dico le diga que no debe tomar Noklot.
  • Informe a su mГ©dico si tiene ha sufrido alguna lesiГіn recientemente y si tiene o ha tenido enfermedad renal o del hГ­gado, o cualquier condiciГіn que pueda causar sangrado, incluidos problemas del estГіmago como Гєlceras y ciertos tipos de problemas de los ojos.
  • Informe a su mГ©dico si estГЎ embarazada, planea quedar embarazada o si estГЎ amamantando. Si queda embarazada mientras toma Noklot, llame a su mГ©dico.
  • Si va a someterse a una cirugГ­a, incluso una cirugГ­a dental, informe a su mГ©dico o dentista que estГЎ tomando Noklot. Su mГ©dico podrГ­a decirle que deje de usar Noklot al menos 5 dГ­as antes de su cirugГ­a para el sangrado excesivo durante la cirugГ­a. Su mГ©dico le dirГЎ cuГЎndo comenzar a tomar Noklot de nuevo despuГ©s de su cirugГ­a.
  • Debe saber que puede sangrar mГЎs fГЎcilmente o por mГЎs tiempo que lo usual mientras toma Noklot. Tenga cuidado de no cortarse ni lastimarse mientras toma Noklot.

How the interaction occurs:

Grapefruit juice may decrease the amount of activated Noklot in your blood.

3. Who can and can't take clop >

Noklot can be taken by adults aged 18 and over.

Noklot isn't suitable for some people. To make sure this medicine is safe for you, tell your doctor if you:

  • have had an allergic reaction to Noklot or any other medicines in the past
  • have a stomach ulcer or have had stomach ulcers in the past
  • have had bleeding in your brain (a brain haemorrhage)
  • have a bleeding disorder, such as haemophilia
  • have liver or kidney problems
  • are trying to get pregnant, already pregnant or breastfeeding

COMMON BRAND(S): Plavix

GENERIC NAME(S): Noklot

OTHER NAME(S): Noklot Tablet

Noklot is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).

It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).

Noklot works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.

Interactions with other medicines

When two or more medicines are taken at the same time, the effects of one of the medicines can alter the effects of the other. This is known as a drug-drug interaction. Noklot can interact with other medicines.

Some of the more common interactions are listed below. However, this is not a complete list.

Q: I've been taking Plavix 75 mg for a year. I just went to my cardiologist and he told me I no longer need it because it's no longer effective. Is this accurate information?

A: Plavix (Noklot) inhibits the platelets in the blood from clotting and is used to prevent blood clots that can occur after a heart attack, stroke and in patients with certain heart and blood vessel disorders. According to the prescribing information available for Plavix (Noklot), lapses in treatment should be avoided and if Plavix must be temporarily discontinued, it should be restarted as soon as possible. Additionally, the prescribing information indicates that premature discontinuation of Plavix (Noklot) may increase the risk for cardiovascular events and there is no mention of Plavix losing its efficacy after one year. It is important to take Plavix (Noklot) exactly as directed by your health care provider and do not take it longer than recommended. The most commonly reported side effect associated with Plavix (Noklot) treatment was bleeding. If you experience any signs and symptoms of bleeding, including nosebleeds or other bleeding that will not stop, coughing up blood or vomit that looks like coffee grounds or black, bloody or tarry stools, it is important to contact your healthcare provider immediately. For more specific information based on your specific condition and current medications, consult with your health care provider, particularly before taking any action. Beth Isaac, PharmD


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