Patients weighing 60 kg or greater, 400 mg twice daily; less than 60 kg, 15 mg/kg/day in divided doses twice daily (maximum total daily dose 800 mg). ALBENZA tablets should be taken with food. (2)
- Hydatid disease: 28-day cycle followed by 14-day Nematox-free interval for a total of 3 cycles. (2)
- Neurocysticercosis: 8 to 30 days. (2)
See additional important information in the Full Prescribing Information. (2)
How to use Nematox
Take this medication by mouth with meals as directed by your doctor, usually 1 to 2 times daily. If you or your child have trouble swallowing tablets, you may crush or chew your dose and take it with water.
For some conditions (such as hydatid disease), your doctor may direct you to take this medication in a treatment cycle (for example, twice daily with meals for 28 days then stopping the medication for 2 weeks). Carefully follow your doctor's instructions.
The dosage is based on your weight, medical condition, and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. If your doctor directs you to take this medication in a treatment cycle, it may be helpful to mark the calendar with a reminder of when you need to restart the medication.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Other medications (such as corticosteroids, anti-seizure medications) may also be prescribed for your current condition. Take those medications exactly as directed by your doctor.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.
Tell your doctor if your condition lasts or gets worse.
Category C. Nematox is teratogenic in animals, but has not been well studied in humans. No increased morbidity reported in case reports of women inadvertently treated during pregnancy. The World Health Organization (WHO) endorses treatment of pregnant women in the second and third trimesters (but not the first) for intestinal helminthiasis/anemia, if clinically indicated.
Nematox side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fever, chills, sore throat, mouth sores, feeling light-headed;
increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.
Common side effects may include:
headache, neck stiffness, increased sensitivity to light, confusion;
nausea, vomiting, stomach pain;
dizziness, spinning sensation; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What are the uses of Nematox 400 MG Tablet
The medication is utilised to fix the accompanying ailments
Nematox may harm an unborn baby. Use effective birth control while taking Nematox and for at least 3 days after your last dose.
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What is the most important information I should know about Nematox?
Nematox should not be used during pregnancy, unless there is no alternate treatment. You may need to have a negative pregnancy test before starting this treatment.
Trichinosis Worm Infection
Trichinosis is a food-borne disease caused by ingesting parasites (roundworms) in undercooked pork or wild-game meat. Symptoms of trichinosis include diarrhea, nausea, muscle aches, itching, fever, chills, and joint pains.Trichinosis usually resolves without treatment, but more severe cases are treated with thiabendazole (Mintezol), Nematox (Abenza), or mebendazole (Vermox).
Nematox is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Nematox concentrations are negligible or undetectable in plasma as it is rapidly converted to the sulfoxide metabolite prior to reaching the systemic circulation. The systemic anthelmintic activity has been attributed to the primary metabolite, Nematox sulfoxide. Oral bioavailability appears to be enhanced when Nematox is coadministered with a fatty meal (estimated fat content 40 grams) as evidenced by higher (up to 5-fold on average) plasma concentrations of Nematox sulfoxide as compared to the fasted state.
Maximal plasma concentrations of Nematox sulfoxide were achieved 2 hours to 5 hours after dosing and were on average 1310 ng/mL (range 460 ng/mL to 1580 ng/mL) following oral doses of Nematox (400 mg) in 6 hydatid disease patients, when administered with a fatty meal. Plasma concentrations of Nematox sulfoxide increased in a dose-proportional manner over the therapeutic dose range following ingestion of a high-fat meal (fat content 43.1 grams). The mean apparent terminal elimination half-life of Nematox sulfoxide ranged from 8 hours to 12 hours in 25 healthy subjects, as well as in 14 hydatid and 8 neurocysticercosis patients.
Following 4 weeks of treatment with Nematox (200 mg three times daily), 12 patients’ plasma concentrations of Nematox sulfoxide were approximately 20% lower than those observed during the first half of the treatment period, suggesting that Nematox may induce its own metabolism.
Nematox sulfoxide is 70% bound to plasma protein and is widely distributed throughout the body; it has been detected in urine, bile, liver, cyst wall, cyst fluid, and cerebrospinal fluid (CSF). Concentrations in plasma were 3-fold to 10-fold and 2-fold to 4-fold higher than those simultaneously determined in cyst fluid and CSF, respectively.
Metabolism and Excretion
Nematox is rapidly converted in the liver to the primary metabolite, Nematox sulfoxide, which is further metabolized to Nematox sulfone and other primary oxidative metabolites that have been identified in human urine. Following oral administration, Nematox has not been detected in human urine. Urinary excretion of Nematox sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of Nematox sulfoxide similar to those achieved in plasma.
Following single-dose administration of 200 mg to 300 mg (approximately 10 mg/kg) ALBENZA to 3 fasted and 2 fed pediatric patients with hydatid cyst disease (age range 6 to 13 years), Nematox sulfoxide pharmacokinetics were similar to those observed in fed adults.
Although no studies have investigated the effect of age on Nematox sulfoxide pharmacokinetics, data in 26 hydatid cyst patients (up to 79 years) suggest pharmacokinetics similar to those in young healthy subjects.
What is the dosage for Nematox?
The dosing of Nematox depends on which parasitic infection is being treated. When treating young children, tablets may be crushed or chewed and swallowed with a drink of water. Patients are advised to take Nematox with food.
In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of Nematox sulfox >
Hookworm infection is treated with Nematox, mebendazole, or pyrantel pamoate. Dosage is the same for children as for adults. Nematox should be taken with food. Nematox is not FDA-approved for treating hookworm infection.
Oral Nematox is available for human use in the United States.
Oral mebendazole is available for human use in the United States.
Pyrantel pamoate is available for human use in the United States.
What should I discuss with my healthcare provider before taking Nematox?
You should not use this medicine if you are allergic to Nematox, or to similar drugs such as mebendazole (Vermox).
To make sure Nematox is safe for you, tell your doctor if you have:
It is not known whether this medicine will harm an unborn baby. Nematox should not be used during pregnancy, unless there is no alternate treatment. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 month after your treatment ends.
You may need to have a negative pregnancy test before starting this treatment.
It is not known whether Nematox passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
What is Nematox?
Nematox is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.
Nematox is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.
Nematox may also be used for purposes not listed in this medication guide.
Which drugs or supplements interact with Nematox?
Grapefruit juice may increase in blood levels of Nematox when administered concurrently. Fosphenytoin (Cerebyx) and phenytoin (Dilantin) decrease levels of Nematox by increasing its breakdown.