N-Propranolol tablets

N-Propranolol

  • Active Ingredient: Propranolol
  • 80 mg, 40 mg, 20 mg
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What is N-Propranolol?

The active ingredient of N-Propranolol brand is propranolol. Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Propranolol Hydrochloride Extended-Release Capsules, USP, are formulated to provide a sustained release of Propranolol hydrochloride. Propranolol Hydrochloride Extended-Release Capsules, USP, are available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration. Each capsule for oral administration contains sugar spheres, ethylcellulose, hypromellose phthalate, povidone, diethyl phthalate, polyethylene glycol, titanium dioxide, ammonium hydroxide, potassium hydroxide, black iron oxide, and gelatin. The 80 mg, 120 mg, and 160 mg capsules contain red and yellow iron oxide. In addition, the 160 mg capsules contain FD&C Blue No. 2. These capsules comply with USP Dissolution Test 1. Propranolol Hydrochloride Extended-Release Capsules, USP, should not be considered a simple mg-for-mg substitute for conventional Propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see DOSAGE AND ADMINISTRATION). When changing to Propranolol Hydrochloride Extended-Release Capsules, USP, from conventional Propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Propranolol Hydrochloride Extended-Release Capsules, USP, have been therapeutically equivalent to the same mg dose of conventional Propranolol as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product. Effects of Propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, Propranolol also exerts a quinidine-like or anesthetic-like membrane action which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the anti-migraine effect of Propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain.

Used for

N-Propranolol is used to treat diseases such as: Angina, Anxiety, Aortic Stenosis, Arrhythmia, Atrial Fibrillation, Benign Essential Tremor, Heart Attack, Hemangioma, High Blood Pressure, Intermittent Explosive Disorder, Migraine Prevention, Mitral Valve Prolapse, Panic Disorder, Performance Anxiety, Pheochromocytoma, Portal Hypertension, Tardive Dyskinesia, Thyrotoxicosis, Ventricular Tachycardia.

Side Effect

Possible side effects of N-Propranolol include: tightness in the chest; restlessness; Abdominal or stomach pain and tenderness; bloody stools; body aches or pain; paleness or cold feeling in the fingertips and toes; euphoria.

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N-Propranolol belongs to the group of medicines known as beta-blockers. It is a medicine which is used to treat several different medical conditions. It works on the heart and blood vessels.

Which drugs or supplements interact with N-Propranolol?

Calcium channel blockers and digoxin (Lanoxin) can lower blood pressure and heart rate to dangerous levels when administered together with N-Propranolol. N-Propranolol can mask the early warning symptoms of low blood sugar (hypoglycemia) and should be used with caution in patients receiving treatment for diabetes. N-Propranolol reduces the metabolism of thioridazine (Mellaril), increasing the concentration of thioridazine in the body and potentially causing abnormal heartbeats.

Before taking N-Propranolol,

  • tell your doctor and pharmacist if you are allergic to N-Propranolol, any other medications, or any ingredients in N-Propranolol products. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: ACE inhibitors; antacids containing aluminum (Maalox, Mylanta, others); anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac, others), nicardipine (Cardene), nifedipine (Adalat, Procardia XL), and nisoldipine (Sular); cholestyramine (Prevalite); cimetidine; ciprofloxacin (Cipro); chlorpromazine; colestipol (Colestid); diazepam (Diastat, Valium); digoxin (Lanoxin); fluvoxamine (Luvox); haloperidol (Haldol); HMG-CoA reductase inhibitors (cholesterol-lowering agents) such as lovastatin (Altoprev, Mevacor, in Advicor) and pravastatin (Pravachol); isoniazid (in Rifamate, in Rifater); medications for depression such as bupropion (Aplenzin, Forfivo XL, Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem, Selfemra), imipramine (Tofranil), and paroxetine (Brisdelle, Paxil, Pexeva); fluconazole (Diflucan); medications for migraine headaches such as rizatriptan (Maxalt) and zolmitriptan (Zomig); medications for high blood pressure such as clonidine (Catapres, Kapvay, in Clorpres), doxazosin (Cardura), prazosin (Minipress), and terazosin; medications for seizures such as phenytoin (Dilantin, Phenytek) and phenobarbital; certain medications for irregular heartbeats such as amiodarone (Cordarone, Nexterone, Pacerone), propafenone (Rythmol), and quinidine (in Nuedexta); monoamine oxidase (MAO) inhibitors such as phenelzine (Nardil); montelukast (Singulair); nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (Indocin, Tivorbex); theophylline (Theo-24, Theochron, Uniphyl); reserpine; rifampin (Rifadin, Rimactane, in Rifater, in Rifamate); ritonavir (Norvir, in Kaletra, in Viekira Pak); teniposide (Vumon); thioridazine; ticlopidine; tolbutamide; tricyclic antidepressants; and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had asthma or other lung disease; heart, liver, or kidney disease; diabetes; severe allergies; or thyroid problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking N-Propranolol, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking N-Propranolol.
  • ask your doctor about the safe use of alcoholic beverages while you are taking N-Propranolol. Alcohol may increase the amount of N-Propranolol in your body.
  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

Minor Side Effects

Some N-Propranolol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common: - in children

  • Anxiety
  • dry mouth
  • hyperventilation
  • irritability
  • restlessness
  • shaking
  • sleepiness or unusual drowsiness
  • trouble sleeping
  • unusual dreams

Less common: - in children

Incidence not known:

  • Dry eyes
  • heartburn
  • loss of strength or energy
  • muscle weakness
  • pain or discomfort in the chest, upper stomach, or throat
  • stomach cramps
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vivid dreams

  • Warning for stopping treatment: Don’t stop taking this medication without talking to your doctor first. Stopping N-Propranolol suddenly can cause changes in your heart rhythm and blood pressure, worsened chest pain, or a heart attack. Your doctor will slowly lower your dosage over several weeks to help prevent these effects.
  • Drowsiness warning: This drug can cause drowsiness. Don’t drive, use machinery, or perform any activities that require alertness until you know how this drug affects you.
  • Diabetes warning: N-Propranolol can cause low blood sugar (hypoglycemia). It may also mask the signs of low blood sugar, such as a heart rate that’s higher than normal, sweating, and shakiness. This drug should be used with caution if you have diabetes, especially if you take insulin or other diabetes drugs that can cause low blood sugar. This drug may also cause low blood sugar in infants, children, and adults who don’t have diabetes. This is more likely after periods of long exercise or if you have k >

N-Propranolol is a prescription drug. It comes in these forms: oral tablet, oral extended-release capsule, oral solution, and injectable.

N-Propranolol oral tablet is only available in a generic form. Generic drugs usually cost less than brand-name versions.

N-Propranolol oral tablet may be used in combination with other drugs.

What is the dosage for N-Propranolol?

The recommended dose for hypertension using short acting formulations is 80-240 mg twice daily. The maximum dose is 640 mg daily.

The usual dose using long acting formulations is 80-160 mg daily.

The recommended dose for chest pain is 80-320 mg daily using short acting formulations and 80-160 mg daily using long acting formulations.

The usual dose for treatment of abnormal heart rhythms is 10-30 mg 3-4 times daily of short acting formulations.

The recommended dose for preventing migraines is 80-240 mg daily.

4. How and when to take it

N-Propranolol comes as 2 different types of medicine: standard release and sustained release (also called modified release).

  • Standard release - releases N-Propranolol into your body quickly. You may need to take it several times a day depending on your dose.
  • Sustained release (SR) - this dissolves slowly so you don't have to take it as often. Once a day is usually enough.

If you are taking it once a day, your doctor may advise you to take your first dose before bedtime, because it can make you feel dizzy. After the first dose, if you don't feel dizzy, take N-Propranolol in the morning.

What brand names are available for N-Propranolol?

Hemangeol, Inderal, Inderal XL, Inderal LA, Innopran XL

How to store N-Propranolol

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

These drugs may decrease the blood pressure-lowering effects of N-Propranolol. If you take these drugs together, your doctor should monitor your blood pressure. They may need to change your N-Propranolol dosage.

Examples of NSAIDs include:

  • diclofenac
  • etodolac
  • fenoprofen
  • ibuprofen
  • indomethacin
  • ketoprofen
  • ketorolac
  • meloxicam
  • nabumetone
  • naproxen
  • oxaprozin
  • piroxicam

What if I take too much?

An overdose of N-Propranolol can slow down your heart rate and make it difficult to breathe. It can also cause dizziness and trembling.

The amount of N-Propranolol that can lead to an overdose varies from person to person.

How to use N-Propranolol HCL

See also Warning section.

Take this medication by mouth, usually 2 to 4 times daily or as directed by your doctor. Take this medication before meals (and at bedtime if taking 4 times daily). Measure the liquid medication with a medication-measuring spoon or device. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. It is important to continue taking this medication even if you feel well.

This medication is used to help prevent chest pain or migraines. It should not be used to treat chest pain or migraines when they occur. Use other medications (e.g., nitroglycerin tablets placed under the tongue for chest pain, sumatriptan for migraines) to relieve sudden attacks as directed by your doctor. Consult your doctor or pharmacist for details.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take N-Propranolol at least 1 hour before or at least 4 hours after these medications.

For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this drug.

Tell your doctor if your condition worsens (e.g., your routine blood pressure readings increase, your chest pain or migraines occur more often).

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use N-Propranolol only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 12.01.

What is N-Propranolol?

N-Propranolol was developed by Sir James Black in the 1960s and this invention won him the Nobel Prize. N-Propranolol is usually sold under its brand name Inderal, though the generic form of the drug is also available. N-Propranolol is a beta-blocker which, when administered, inhibits the activity of the adrenergic receptors present in the body. By preventing the stimulation of the receptors, N-Propranolol, like other beta blockers help in reducing the cardiac response to stimuli. This helps in lowering the rate of heartbeats as well as blood pressure, both of which allow the heart to beat at a much-relaxed pace.

When administered to patients with performance anxiety, N-Propranolol can help minimize the symptoms that occur. However, it doesn’t treat the actual issue.

Typical Uses

N-Propranolol is most widely used for heart conditions. It is one of the medications approved to lower blood pressure. It can control heart rate in people who have fast heart rhythms, such as atrial fibrillation or ventricular tachycardia. Many people also use N-Propranolol to prevent migraines or reduce symptoms of tremors. The liquid formulation is also approved for infants who have proliferating infantile hemangioma.


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