Kalpress tablets

Kalpress

  • Active Ingredient: Valsartan
  • 160 mg, 80 mg, 40 mg
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What is Kalpress?

The active ingredient of Kalpress brand is valsartan. Valsartan is an angiotensin II receptor antagonist. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Used for

Kalpress is used to treat diseases such as: Heart Attack, Heart Failure, High Blood Pressure, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Kalpress include: numbness or tingling in the hands, feet, or lips; trouble with swallowing or breathing (sudden); nausea; diarrhea; Dark urine.

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Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Kalpress. For a full list, see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

What Are Side Effects Associated with Using Kalpress?

Side effects associated with use of Kalpress, include the following:

Other side effects of Kalpress include:

Postmarketing side effects of Kalpress reported include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Q: I take omeprazole before breakfast. About 30 minutes later I take Diovan, also before breakfast. I like to drink orange juice or V8 with it. Is this okay? I heard that you shouldn't drink grapefruit juice with blood pressure medications. I take a fish oil capsule in the middle of breakfast, so I don't burp it up. I take the rest of my vitamins after. Are the juices going to have an effect on the vitamins?

A: Eating grapefruit or drinking grapefruit juice, as well as consuming tangelos and Seville oranges, can be dangerous when taking certain medications. Chemicals in these fruits interfere with the specific enzymes that break down (metabolize) the medications. This can lead to much higher blood levels of these medications and can cause serious side effects. Both the fruit and the juice contain these chemicals. Drugs that interact with these fruits include the anti-seizure medication carbamazepine (anti-seizure); the antidepressant Zoloft (sertraline); the anti-anxiety drug Valium; the calcium channel blocker medications nimodipine and nifedipine (for high blood pressure); cholesterol-lowering medications (including Lipitor and Zocor); immunosuppressants such as cyclosporine and tacrolimus; the pain medication methadone; Viagra (for erectile dysfunction); and HIV medications (saquinavir, indinavir). So if you are taking any of these medications, you should avoid grapefruits, tangelos, and Seville oranges. However, neither omeprazole (Prilosec) nor Diovan (Kalpress) are likely to interact with grapefruit. Other fruit juices, like plain orange juice or tomato juice, do not have the same effect. Omeprazole is usually taken before eating. You may take Diovan (Kalpress) with or without food. Consult your healthcare provider for more specific information. You may also find helpful information at //www.everydayhealth.com/drugs/prilosec and //www.everydayhealth.com/drugs/diovan Sarah Lewis, PharmD

Diovan (Kalpress) has been evaluated for safety in more than 4,000 patients, including over 400 treated for over 6 months, and more than 160 for over 1 year. Adverse reactions have generally been mild and transient in nature and have only infrequently required discontinuation of therapy. The overall incidence of adverse reactions with Diovan was similar to placebo.

The overall frequency of adverse reactions was neither dose-related nor related to gender, age, race, or regimen. Discontinuation of therapy due to side effects was required in 2.3% of Kalpress patients and 2.0% of placebo patients. The most common reasons for discontinuation of therapy with Diovan were headache and dizziness.

The adverse reactions that occurred in placebo-controlled clinical trials in at least 1% of patients treated with Diovan and at a higher inc >

In trials in which Kalpress was compared to an ACE inhibitor with or without placebo, the incidence of dry cough was significantly greater in the ACE-inhibitor group (7.9%) than in the groups who received Kalpress (2.6%) or placebo (1.5%). In a 129-patient trial limited to patients who had had dry cough when they had previously received ACE inhibitors, the incidences of cough in patients who received Kalpress, HCTZ, or lisinopril were 20%, 19%, and 69% respectively (p 0.2% of Kalpress patients) are listed below. It cannot be determined whether these events were causally related to Diovan.

Body as a Whole: Allergic reaction and asthenia

Neurologic and Psychiatric: Anxiety, insomnia, paresthesia, and somnolence

Other reported events seen less frequently in clinical trials included chest pain, syncope, anorexia, vomiting, and angioedema.

What Other Drugs Interact with Kalpress?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe interactions of Kalpress include:

Serious interactions of Kalpress include:

Kalpress has moderate interactions with at least 150 different drugs.

Mild Interactions of Kalpress include:

  • agrimony
  • cornsilk
  • food
  • lofexidine
  • noni juice
  • octacosanol
  • ombitasvir/paritaprevir/ritonavir and dasabuvir
  • reishi
  • Shepherd's purse
  • simvastatin

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What is Kalpress?

Kalpress is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. Kalpress is sometimes given together with other blood pressure medications.

Kalpress is also used in adults to treat heart failure, and to lower the risk of death after a heart attack.

Kalpress may also be used for purposes not listed in this medication guide.

Before taking Kalpress,

  • tell your doctor and pharmacist if you are allergic to Kalpress, any other medications, or any of the ingredients in Kalpress tablets or solution.
  • tell your doctor if you have diabetes (high blood sugar) and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take Kalpress if you have diabetes and you are also taking aliskiren.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril, (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) and selective COX-2 inhibitors such as celecoxib (Celebrex); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'), including potassium-sparing diuretics such as amiloride (Midamor), spironolactone (Aldactone, in Aldactazide), and triamterene (Dyrenium, in Dyazide, in Maxzide); gemfibrozil (Lopid), other medications to treat high blood pressure or a heart problem; potassium supplements; rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and ritonavir (Norvir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had blockage of the bile duct (condition when bile cannot flow from the liver to the gallbladder and small intestine, which can occur with gallstones, tumors, or injury); heart, kidney, or liver disease.
  • tell your doctor if you are breastfeeding. Do not breastfeed during your treatment with Kalpress.
  • you should know that Kalpress may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Kalpress. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting. Tell your doctor if you have any of these problems or develop them during your treatment.

Mechanism Of Action

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Diovan (Kalpress) blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis. Kalpress has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. The increased plasma levels of angiotensin II following AT1 receptor blockade with Kalpress may stimulate the unblocked AT2 receptor. The primary metabolite of Kalpress is essentially inactive with an affinity for the AT1 receptor about one-200th that of Kalpress itself.

Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because Kalpress does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. Kalpress does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of Kalpress on blood pressure.

More common side effects

The more common side effects that can occur with Kalpress if you’re taking it for high blood pressure include:

  • headache
  • dizziness
  • flu-like symptoms, such as fever and body aches
  • tiredness
  • stomach (abdominal) pain

The more common side effects that can occur with Kalpress if you’re taking it for heart failure include:

  • dizziness
  • low blood pressure
  • diarrhea
  • joint and back pain
  • tiredness
  • symptoms of high blood potassium, such as heart rhythm problems, muscle weakness, and slow heart rate

The more common side effects that can occur with Kalpress if you’re taking it to increase survival after you’ve had a heart attack include:

  • low blood pressure
  • cough
  • skin rash

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Q: Does Diovan HCT cause weight gain?

A: Weight gain is not listed as an adverse reaction in Diovan HCT's package insert. According to Diovan HCT's patient information, kidney problems may become worse in people who already have kidney disease and take Diovan HCT. Diovan HCT's patient information advises patients to contact their doctor if they experience swelling in the feet, ankles, or hands, or have unexplained weight gain. This information is solely educational. It's important for patients to consult their physician or health care provider about any specific question regarding their medical conditions or medications -- particularly before taking any action. To learn more about Diovan HCT on Everyday Health's Web site, follow this link: //www.everydayhealth.com/drugs/hydrochlorothiazide-Kalpress.

Renal impairment

  • GFR ≥30 mL/min/1.73m²: No dosage adjustment necessary
  • GFR Enter a drug name and Kalpress

1. About Kalpress

Kalpress is a medicine widely used to treat high blood pressure and heart failure. It's also sometimes prescribed after a heart attack.

Kalpress is only available on prescription. It comes as tablets, capsules and as a liquid that you swallow.

Q: I take Diovan. Can it cause me to be unsteady?

A: Diovan (Kalpress) is used to treat high blood pressure and heart failure. It works by preventing the blood vessels from narrowing and improving blood flow. Common side effects of Diovan include dry mouth, cough, nausea, and diarrhea. Furthermore, headaches and dizziness were the most common side effects that caused patients to discontinue using Diovan. For more specific information about Diovan, go to //www.everydayhealth.com/drugs/diovan. You should also consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD

General

  • This drug should be taken at the same time every day.
  • You may be able to cut or crush certain strengths of Kalpress tablets. Ask your doctor or pharmacist whether you can cut or crush your tablets.

Background

Kalpress (val sar' tan) was the second angiotensin II receptor blocker (ARB) to be approved for use in the United States and is widely used for therapy of hypertension. Kalpress inhibits the renin-angiotensin system by blocking the angiotensin II type 1 receptor (AT1), which prevents the vasoconstriction and volume expansion induced by circulating angiotensin II which accounts for its antihypertensive activity. Kalpress was approved for use in the United States for hypertension in 1996 and indications were subsequently broaded to the treatment of heart failure and for reduction in cardiovascular mortality in patients with left ventricular dysfunction after myocardial infarction. Kalpress is available in 40, 80, 160 and 320 mg tablets generically and under the trade name Diovan. The typical initial dose of Kalpress in adults in 80 to 160 mg once daily, and it is used long term. Kalpress is also available in fixed combinations with hydrochlorothiazide (Diovan-HCT), amlodipine (Exforge and Exforge HCT) and aliskiren (Valturna). Side effects of Kalpress are uncommon, but can include headache, dizziness, fatigue, cough, gastrointestinal upset, and fetal toxicity. In addition, many ARBs including Kalpress have been linked to cases of severe sprue-like enteropathy. The enteropathy arises after months or years of therapy and presents with severe diarrhea, weight loss, abdominal discomfort and fatigue. Intestinal biopsy shows villous flattening and atrophy similar to celiac disease. However, the enteropathy does not improve with a gluten-free diet but does resolve with stopping the angiotensin receptor blocker.

Kalpress side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Also call your doctor at once if you have:

a light-headed feeling, like you might pass out;

swelling, rapid weight gain;

shortness of breath;

little or no urination;

pounding heartbeats or fluttering in your chest; or

high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects may include:

stomach pain, diarrhea; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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