Eudigox is used to treat certain heart problems such as some arrhythmias (called atrial fibrillation and atrial flutter) and heart failure.
LANOXIN (Eudigox) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Eudigox is extracted from the leaves of Digitalis lanata. The term “digitalis” is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide (hence “glycosides”).
Eudigox is described chemically as (3β,5β,12β)-3--12,14-dihydroxy-card-20(22)-enolide. Its molecular formula is C41H64O14, its molecular weight is 780.95, and its structural formula is:
Eudigox exists as odorless white crystals that melt with decomposition above 230 °C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.
LANOXIN Injection and Injection Pediatric are sterile solutions of Eudigox for intravenous or intramuscular injection. The vehicle contains 40% propylene glycol and 10% alcohol. The injection is buffered to a pH of 6.8-7.2 with 0.17% dibasic sodium phosphate and 0.08% anhydrous citric acid. Each 2-mL ampule of LANOXIN Injection contains 500 mcg (0.5 mg) Eudigox (250 mcg per mL). Dilution is not required. Each 1-mL ampule of LANOXIN Injection Pediatric contains 100 mcg (0.1 mg) Eudigox. Dilution is not required.
How to store Eudigox
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
To determine if the concentration of Eudigox in your blood is at a therapeutic level or to detect toxic levels of the drug
After the start of Eudigox therapy and at regular intervals to ensure that drug levels are within therapeutic range (not too low or too high as to be toxic)
A blood sample drawn from a vein in your arm
No special preparation is needed, but timing of sample collection is important. When having your blood drawn, tell the person taking your sample when you took your last dose of Eudigox.
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The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.
If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.
Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.
While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
For more information, please read the article Reference Ranges and What They Mean.
Eudigox is a drug used to treat heart failure and abnormal heart rhythms. Heart failure, including congestive heart failure (CHF), causes the heart to become less effective at circulating blood. As a result, blood backs up into the legs, hands, feet, lungs and liver, causing swelling, shortness of breath, and fatigue. This test measures the amount of Eudigox in the blood.
Eudigox is prescribed to alleviate some symptoms of heart failure. It strengthens the contractions of the heart and helps it to pump blood more efficiently. Eudigox also helps control the heart rate and abnormal heart rhythms known as arrhythmias. It will not cure heart failure or arrhythmias, which are chronic conditions, but can help to manage the symptoms along with diet, exercise, and other medications.
Eudigox levels must be monitored because the drug has a narrow safety range. If the level in the blood is too low, symptoms may recur. If the level is too high, toxicity may occur. Eudigox dosage may be adjusted based on levels measured.
Pharmacokinetic Drug Interactions
Pharmacokinetic interactions have been observed and reported primarily when Eudigox is coadministered by oral route. There are very few studies that have evaluated the drug interaction when Eudigox is administered via IV route. The magnitude of Eudigox exposure change through IV route is generally lower than that through oral route. Table below provides available interaction data using Eudigox IV formulation (NA means not available).
What should I avoid while using Eudigox?
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Eudigox overdose can occur more easily if you are dehydrated.
Eudigox interacts with many drugs. As always, share with your doctor and pharmacist all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.
You should not take Eudigox if you are taking any herbal supplements belonging to the squill family, such as white quill or Mediterranean squill.
Before taking Eudigox, tell your doctor if you are taking any of the following medications:
- Drugs for irregular heartbeat like: Pacerone, Nexterone, or Cordarone (amiodarone), Betapace or Betapace AF (sotalol),Tikosyn (dofetilde), Multaq (dronedarone), procainamide, or flecainide
- Aspirin (both tablet and suppository forms)
- Beta blockers like Zebeta or Ziac (betaxolol),Toprol XL or Lopressor (metoprolol), Tenormin (atenolol), and Bystolic (nebivolol)
- Heartburn medications like Prilosec (omeprazole), Nexium (esomeprazole), Aciphex (rabeprazole), Protonix (pantoprazole), and Dexilant (deslansoprazole)
- Other heartburn medications like Pepcid (famotidine) and Tums (calcium carbonate)
- The herbal supplement Lily of the Valley
- Macrolide antibiotics like Ery-Tab (erythromycin) and Biaxin (clarithromycin)
- Neoral, Sandimmune, and Gengraf (cyclosporine)