Enapril-H tablets

Enapril-H

  • Active Ingredient: Enalapril
  • 10 mg, 5 mg
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What is Enapril-H?

The active ingredient of Enapril-H brand is enalapril. Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. C20H28N2O5в€™C4H4O4 M.W. 492.53 Enalapril maleate, USP is an off-white, crystalline powder. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin converting enzyme inhibitor. Enalapril maleate tablets USP are supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition, each tablet contains the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium bicarbonate. Each 2.5 mg tablet contains D&C red #27 aluminum lake, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, and FD&C yellow #6 aluminum lake. Each 10 mg tablet contains FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake and FD&C yellow #6 aluminum lake. Each 20 mg tablet contains FD&C Yellow #6.

Used for

Enapril-H is used to treat diseases such as: Alport Syndrome, Diabetic Kidney Disease, Heart Failure, High Blood Pressure, Hypertensive Emergency, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Enapril-H include: Lack or loss of strength; fever or chills; fainting; sneezing; confusion; Chest pain; rash.

How to Buy Enapril-H tablets online?

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¿Cuáles son los posibles efectos secundarios del Enapril-H?

Busque atención médica de emergencia si usted tiene síntomas de una reacción alérgica: ronchas; dolor severo de estómago; dificultad para respirar; hinchazón de la cara, labios, lengua, o garganta.

Llame a su médico de inmediato si usted tiene:

  • sensación de desvanecimiento, como que se va a desmayar;
  • latidos cardíacos lentos;
  • latidos cardíacos fuertes o aleteo cardíaco en su pecho;
  • poco o nada de orina;
  • ictericia (color amarillo de la piel u ojos);
  • entumecimiento, hormigueo, o dolor con sensación de quemazón en sus manos o pies;
  • fiebre, escalofríos, síntomas del resfrío o de la gripe;
  • moretones fácil, sangrado inusual; o
  • nivel alto de potasio --náusea, debilidad, sensación de hormigueo, dolor de pecho, latidos cardíacos irregulares, pérdida de movimiento.

Efectos secundarios comunes pueden incluir:

  • mareo, sentirse cansado;
  • tos; o
  • sentir que se va a desmayar.

Esta lista no menciona todos los efectos secundarios y puede ser que ocurran otros. Llame a su médico para consejos médicos relacionados a efectos secundarios. Usted puede reportar efectos secundarios llamando al FDA al 1-800-FDA-1088.

As with all vasodilators, Enapril-H should be given with caution to patients with obstruction in the outflow tract of the left ventricle.

Contraindications

Hypersensitivity to Enapril-H/other ACE inhibitors

History of ACE inhibitor-induced angioedema, hereditary or idiopathic angioedema

Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan

Do not coadminister with aliskiren in patients with diabetes mellitus or with renal impairment (ie, GFR Formulary Patient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Q: What high blood pressure medication can I take that will not cause weight gain? I take Enapril-H and have gained 30 pounds. I have pre-diabetes and also take hydrochlorothiazide when needed.

A: Typically, medications used to treat high blood pressure do not cause gradual weight gain as a side effect. If weight gain is an issue, it may be due to fluid retention and should be discussed with your physician. Your physician can evaluate your health conditions and medications and make any necessary changes to your treatment regimen. Enapril-H (Vasotec) is a medication in the group of drugs called angiotensin converting enzyme (ACE) inhibitors that work by causing blood vessels to relax which lowers blood pressure. According to the prescribing information for Enapril-H, weight gain was not a reported side effect associated with the medication. If you notice a rapid weight gain with this medication, this may be due to fluid retention and should be brought to your physician's attention. If you are noticing gradual weight gain with Enapril-H there are some things you can do to help. Eat a heart healthy diet containing a lot of fruits, vegetables, grains, low fat milk products. Avoid or limit the amount of saturated fats, cholesterol, salt and sugars in your diet. Regular physical activity, lasting at least 30 minutes, on most days of the week is also beneficial. Consult with your physician about any restrictions to exercise you may have. Limit your intake of alcohol. If you are experiencing weight gain as a side effect of Enapril-H, you should consult with your physician. For more specific information, consult with your doctor for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

By Don Wall | Medically Reviewed by Sherry Brooks, MD

Latest Update: 2014-10-27 Copyright © 2014 Everyday Health Media, LLC

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Breathing problems. Symptoms include:
    • trouble breathing or swallowing
    • hoarseness
    • tightness in your chest
  • yellowing of your skin or the whites of your eyes
  • lightheadedness
  • fainting
  • inability to pass urine
  • change in the amount of urine you pass
  • blood in your urine
  • weight gain
  • weakness
  • lightheadedness or dizziness
  • numbness or tingling
  • shortness of breath
  • irregular heartbeat
  • Swelling (angioedema) of your face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • fever
  • sore throat
  • chills
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Enapril-H oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Enapril-H are listed below.

    Hypotension

    Excessive hypotension is rare in uncomplicated hypertensive patients treated with VASOTEC alone. Patients with heart failure given VASOTEC commonly have some reduction in blood pressure, especially with the first dose, but discontinuation of therapy for continuing symptomatic hypotension usually is not necessary when dosing instructions are followed; caution should be observed when initiating therapy (see DOSAGE AND ADMINISTRATION). Patients at risk for excessive hypotension, sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high-dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. It may be advisable to eliminate the diuretic (except in patients with heart failure), reduce the diuretic dose or increase salt intake cautiously before initiating therapy with VASOTEC in patients at risk for excessive hypotension who are able to tolerate such adjustments (see DRUG INTERACTIONS and ADVERSE REACTIONS). In patients at risk for excessive hypotension, therapy should be started under very close medical supervision and such patients should be followed closely for the first two weeks of treatment and whenever the dose of Enapril-H and/or diuretic is increased. Similar considerations may apply to patients with ischemic heart or cerebrovascular disease, in whom an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident.

    If excessive hypotension occurs, the patient should be placed in the supine position and, if necessary, receive an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further doses of VASOTEC, which usually can be given without difficulty once the blood pressure has stabilized. If symptomatic hypotension develops, a dose reduction or discontinuation of VASOTEC or concomitant diuretic may be necessary.

    In trials in patients treated with digitalis and diuretics, treatment with Enapril-H resulted in decreased systemic vascular resistance, blood pressure, pulmonary capillary wedge pressure and heart size, and increased cardiac output and exercise tolerance. Heart rate was unchanged or slightly reduced, and mean ejection fraction was unchanged or increased. There was a beneficial effect on severity of heart failure as measured by the New York Heart Association (NYHA) classification and on symptoms of dyspnea and fatigue. Hemodynamic effects were observed after the first dose and appeared to be maintained in uncontrolled studies lasting as long as four months. Effects on exercise tolerance, heart size, and severity and symptoms of heart failure were observed in placebo-controlled studies lasting from eight weeks to over one year.

    Neutropenia/Agranulocytosis

    Another angiotensin converting enzyme inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow depression, rarely in uncomplicated patients but more frequently in patients with renal impairment, especially if they also have a collagen vascular disease. Available data from clinical trials of Enapril-H are insufficient to show that Enapril-H does not cause agranulocytosis at similar rates. Marketing experience has revealed cases of neutropenia or agranulocytosis in which a causal relationship to Enapril-H cannot be excluded. Periodic monitoring of white blood cell counts in patients with collagen vascular disease and renal disease should be considered.

    Warnings for other groups

    For pregnant women: This drug can have a negative impact on the development of a fetus. Enapril-H should only be used during pregnancy in serious cases where it’s needed to treat a dangerous condition in the mother.

    Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should only be used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

    For women who are breastfeeding: Enapril-H may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

    For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

    For children: Enapril-H shouldn’t be used to treat high blood pressure in infants and children with severe kidney disease. The use of this medication to treat heart failure or asymptomatic left ventricular dysfunction hasn’t been studied in children. This drug shouldn’t be used to treat these conditions in people younger than 18 years.

    This dosage information is for Enapril-H oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

    • your age
    • the condition being treated
    • how severe your condition is
    • other medical conditions you have
    • how you react to the first dose

    Immediate action required: Call 999 or go to A&E if:

    • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
    • you're wheezing
    • you get tightness in the chest or throat
    • you have trouble breathing or talking
    • your mouth, face, lips, tongue or throat start swelling

    You could be having a serious allergic reaction and may need immediate treatment in hospital.

    These are not all the side effects of Enapril-H. For a full list see the leaflet inside your medicines packet.

    You can report any suspected side effect to the UK safety scheme.


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