Enapril tablets

Enapril

  • Active Ingredient: Enalapril
  • 10 mg, 5 mg
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What is Enapril?

The active ingredient of Enapril brand is enalapril. Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. C20H28N2O5в€™C4H4O4 M.W. 492.53 Enalapril maleate, USP is an off-white, crystalline powder. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin converting enzyme inhibitor. Enalapril maleate tablets USP are supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition, each tablet contains the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium bicarbonate. Each 2.5 mg tablet contains D&C red #27 aluminum lake, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, and FD&C yellow #6 aluminum lake. Each 10 mg tablet contains FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake and FD&C yellow #6 aluminum lake. Each 20 mg tablet contains FD&C Yellow #6.

Used for

Enapril is used to treat diseases such as: Alport Syndrome, Diabetic Kidney Disease, Heart Failure, High Blood Pressure, Hypertensive Emergency, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Enapril include: Blurred vision; Chest pain; rash; unusual tiredness or weakness; Lack or loss of strength.

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Short-Term Effects

Dry hacking nonproductive cough may occur within few months of treatment; consider other causes of cough prior to discontinuation.

See "What Are Side Effects Associated with Using Enapril?”

What if I get ill while I'm taking it?

If you get severe diarrhoea or vomiting for any reason, stop taking Enapril. When you're able to eat and drink normally, wait for 24 to 48 hours, then start to take it again.

If you have questions about this, contact your doctor or pharmacist.

Forms and strengths

Brand: Vasotec

  • Form: Oral tablet
  • Strengths: 2.5 mg, 5 mg, 10 mg, and 20 mg

Generic: Enapril

  • Form: Oral tablet
  • Strengths: 2.5 mg, 5 mg, 10 mg, and 20 mg

Other uses for this medicine

Enapril is also sometimes used to treat kidney disease related to diabetes. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

6. How to cope with s >

What to do about:

  • dry, tickly cough - cough medicines don't usually help for coughs caused by Enapril. Sometimes the cough will get better on its own if you keep taking Enapril. Talk to your doctor if it carries on, bothers you or stops you from sleeping. Another medicine may suit you better. If your doctor recommends that you stop taking Enapril, the cough may take a few days to a month to go away.
  • feeling dizzy - if Enapril makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Don't drive or use tools or machines while you're feeling dizzy or shaky.
  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
  • diarrhoea - drink lots of fluids, such as water or squash, to avoid dehydration. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Don't take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • itching or a mild rash - it may help to take an antihistamine which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.
  • blurred vision - avoid driving or using tools or machines while this is happening. If it lasts for more than a day or two speak to your doctor as they may need to change your treatment.

Important: if you experience any of the following potentially serious symptoms, stop taking Enapril and contact your doctor for advice straightaway:

  • Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.
  • Any yellowing of your skin or the whites of your eyes. These may be signs of a liver problem called jaundice, which is a rare side-effect.
  • A severe skin rash.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

Before taking Enapril

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Enapril it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you have any problems with the way your k >

Long-Term Effects

Taking Enapril in large amounts for a long period of time may be unsafe. Enapril contains chemicals that are considered cancer-causing (carcinogens).

See "What Are Side Effects Associated with Using Enapril?”

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VASOTEC® (Enapril maleate) Tablets

  • When pregnancy is detected, discontinue VASOTEC® as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity

Cautions

For hypertension patients on diuretics, if possible discontinue diuretics 2-3 days before starting Enapril.

Excessive hypotension if concomitant diuretics, hypovolemia, or hyponatremia.

Risk of high blood potassium (hyperkalemia), especially in patients with renal impairment or diabetes mellitus or in those taking concomitant potassium-elevating drugs.

Dual blockade of the renin angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared to monotherapy.

Injection contains benzyl alcohol preservative (linked to potentially fatal "gasping syndrome" in preemies).

ACE inhibition also causes an increase in bradykinin levels, which putatively mediates angioedema.

Angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors.

If laryngeal stridor or angioedema of the face, tongue, or glottis occurs discontinue therapy and institute appropriate therapy immediately.

Patients receiving co-administration of ACE inhibitor and mTOR (mammalian target of rapamycin) inhibitor (e.g. temsirolimus, sirolimus, everolimus) therapy may be at increased risk for angioedema Intestinal angioedema has been reported in patients treated with ACE inhibitors.

Dry hacking nonproductive cough may occur within few months of treatment; consider other causes of cough prior to discontinuation.

Agranulocytosis, neutropenia, or leukopenia with myeloid hypoplasia reported with other ACE inhibitor; patients with renal impairment are at high risk; monitor CBC with differential in these patients.

Discontinue immediately if patient becomes pregnant.

Less effective in people of African ethnicity.

How should I take Enapril?

Take Enapril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Enapril with or without food.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Enapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

If you need surgery, tell the surgeon ahead of time that you are using Enapril.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Store the liquid medicine in the refrigerator, do not freeze. Throw away any liquid medicine not used within 60 days.

Warnings for other groups

For pregnant women: This drug can have a negative impact on the development of a fetus. Enapril should only be used during pregnancy in serious cases where it’s needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should only be used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

For women who are breastfeeding: Enapril may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

For children: Enapril shouldn’t be used to treat high blood pressure in infants and children with severe kidney disease. The use of this medication to treat heart failure or asymptomatic left ventricular dysfunction hasn’t been studied in children. This drug shouldn’t be used to treat these conditions in people younger than 18 years.

This dosage information is for Enapril oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Enapril side effects

Get emergency medical help if you have signs of an allergic reaction to Enapril: hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

pounding heartbeats or fluttering in your chest;

little or no urination;

jaundice (yellowing of the skin or eyes);

numbness, tingling, or burning pain in your hands or feet;

fever, chills, cold or flu symptoms;

easy bruising, unusual bleeding; or

high potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common Enapril side effects may include:

dizziness, feeling tired;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drugs used to prevent rejection of an organ transplant

These medications increase your risk of angioedema (sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines) when taken with Enapril.

Examples of these drugs include:


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