Duranol tablets

Duranol

  • Active Ingredient: Propranolol
  • 80 mg, 40 mg, 20 mg
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What is Duranol?

The active ingredient of Duranol brand is propranolol. Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Propranolol Hydrochloride Extended-Release Capsules, USP, are formulated to provide a sustained release of Propranolol hydrochloride. Propranolol Hydrochloride Extended-Release Capsules, USP, are available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration. Each capsule for oral administration contains sugar spheres, ethylcellulose, hypromellose phthalate, povidone, diethyl phthalate, polyethylene glycol, titanium dioxide, ammonium hydroxide, potassium hydroxide, black iron oxide, and gelatin. The 80 mg, 120 mg, and 160 mg capsules contain red and yellow iron oxide. In addition, the 160 mg capsules contain FD&C Blue No. 2. These capsules comply with USP Dissolution Test 1. Propranolol Hydrochloride Extended-Release Capsules, USP, should not be considered a simple mg-for-mg substitute for conventional Propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see DOSAGE AND ADMINISTRATION). When changing to Propranolol Hydrochloride Extended-Release Capsules, USP, from conventional Propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Propranolol Hydrochloride Extended-Release Capsules, USP, have been therapeutically equivalent to the same mg dose of conventional Propranolol as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product. Effects of Propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, Propranolol also exerts a quinidine-like or anesthetic-like membrane action which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the anti-migraine effect of Propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain.

Used for

Duranol is used to treat diseases such as: Angina, Anxiety, Aortic Stenosis, Arrhythmia, Atrial Fibrillation, Benign Essential Tremor, Heart Attack, Hemangioma, High Blood Pressure, Intermittent Explosive Disorder, Migraine Prevention, Mitral Valve Prolapse, Panic Disorder, Performance Anxiety, Pheochromocytoma, Portal Hypertension, Tardive Dyskinesia, Thyrotoxicosis, Ventricular Tachycardia.

Side Effect

Possible side effects of Duranol include: double vision; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; hair loss; peculiar postures or movements, mannerisms, or grimacing; Abdominal or stomach pain and tenderness.

How to Buy Duranol tablets online?

To buy Duranol online - simply click on the "Buy Now" button from the top and follow on to our store. Payment and Order takes a few minutes, and all steps are evident. We don't take a medical prescription plus we have many procedures of payment. Considering all the details of fast delivery and confidentiality, then you can read on the applicable pages on the hyperlinks in the top menu.

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How should this medicine be used?

Duranol comes as a tablet, solution (liquid),and as an extended-release (long-acting) capsule to take by mouth. The extended-release Duranol capsule (brand name: Inderal LA) usually is taken once a day. The extended-release capsule (Innopran XL, Inderal XL) is usually taken at bedtime and should consistently be taken either always with or always without food each time. Immediate-acting Duranol tablets or solution may be taken two, three, or four times a day. Take Duranol at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Duranol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release capsules whole; do not split, chew, or crush them.

What if I take too much?

An overdose of Duranol can slow down your heart rate and make it difficult to breathe. It can also cause dizziness and trembling.

The amount of Duranol that can lead to an overdose varies from person to person.

Duranol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness or lightheadedness
  • tiredness
  • diarrhea
  • constipation

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Allergic reactions. Symptoms can include:
    • skin rash
    • itching
    • hives
    • swelling of your face, lips, or tongue
  • Breathing problems
  • Changes in blood sugar
  • Cold hands or feet
  • Nightmares or trouble sleeping
  • Dry, peeling skin
  • Hallucinations
  • Muscle cramps or weakness
  • Slow heart rate
  • Swelling of your legs or ankles
  • Sudden weight gain
  • vomiting

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Duranol oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with Duranol are listed below.

Duranol belongs to the group of medicines known as beta-blockers. It is a medicine which is used to treat several different medical conditions. It works on the heart and blood vessels.

Before taking this medicine

You should not use Duranol if you are allergic to it, or if you have:

very slow heart beats that have caused you to faint; or

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker).

Babies who weigh less than 4.5 pounds should not be given Hemangeol oral liquid.

To make sure Duranol is safe for you, tell your doctor if you have:

a muscle disorder;

bronchitis, emphysema, or other breathing disorders;

low blood sugar, or diabetes (Duranol can make it harder for you to tell when you have low blood sugar);

slow heartbeats, low blood pressure;

congestive heart failure;

liver or kidney disease;

a thyroid disorder;

pheochromocytoma (tumor of the adrenal gland); or

problems with circulation (such as Raynaud's syndrome).

It is not known whether Duranol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Duranol.

Duranol can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

1. About Duranol

Duranol belongs to a group of medicines called beta blockers. It's used to treat heart problems, help with anxiety and prevent migraines.

If you have a heart problem, you can take Duranol to:

  • treat high blood pressure
  • treat illnesses that cause an irregular heartbeat, like atrial fibrillation
  • prevent future heart disease, heart attacks and strokes
  • prevent chest pain caused by angina

Duranol can help reduce your symptoms if you have too much thyroid hormone in your body (thyrotoxicosis). You'll usually take it together with medicines to treat an overactive thyroid.

This medicine is only available on prescription. It comes as tablets, capsules, or as a liquid to swallow

Off-Label Uses

Duranol has been used off-label for a variety of indications over time, as well. An off-label indication is the use of a medication for a reason not specifically approved by the FDA but often widely accepted by doctors. Some of these indications for Duranol include controlling symptoms of chest pain in patients with coronary artery disease, managing symptoms of high thyroid levels, and reducing the risk of a variceal bleed in patients with liver failure. It has also been used to treat aggression in some cases.

Drug to treat stomach ulcers

Taking cimetidine with Duranol can increase the levels of Duranol in your blood. This can cause more side effects.

DESCRIPTION

Inderal® (Duranol hydrochloride) is a synthetic beta-adrenergic receptor blocking agent chemically described as 2-Propanol, 1--3-(1-naphthalenyloxy)-, hydrochloride,(±)-. Its molecular and structural formulae are:

Duranol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

Inderal (Duranol) is available as 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration.

The inactive ingredients contained in Inderal (Duranol) Tablets are: lactose, magnesium stearate, microcrystalline cellulose, and stearic acid. In addition, Inderal (Duranol) 10 mg and 80 mg Tablets contain FD&C Yellow No. 6 and D&C Yellow No. 10; Inderal (Duranol) 20 mg Tablets contain FD&C Blue No. 1; Inderal (Duranol) 40 mg Tablets contain FD&C Blue No. 1, FD&C Yellow No. 6, and D&C Yellow No. 10; Inderal (Duranol) 60 mg Tablets contain D&C Red No. 30.

IMPORTANT WARNING:

Do not stop taking Duranol without talking to your doctor first. If Duranol is stopped suddenly, it may cause chest pain or heart attack in some people.

HOW SUPPLIED

Inderal® (Duranol hydrochloride) Tablets

INDERAL 10—Each hexagonal-shaped, orange, scored tablet, embossed with an "I" and imprinted with "INDERAL 10," contains 10 mg Duranol hydrochloride, in bottles of 100 (NDC 24090) and 5,000 (NDC 24090-421-88).

Store at controlled room temperature 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F).

Dispense in a well-closed container as defined in the USP.

INDERAL 20—Each hexagonal-shaped, blue, scored tablet, embossed with an "I" and imprinted with "INDERAL 20," contains 20 mg Duranol hydrochloride, in bottles of 100 (NDC 24090-422-88).

Store at controlled room temperature 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F).

Dispense in a well-closed, light-resistant container as defined in the USP.

Protect from light.

Use carton to protect contents from light.

INDERAL 40—Each hexagonal-shaped, green, scored tablet, embossed with an "I" and imprinted with "INDERAL 40," contains 40 mg Duranol hydrochloride, in bottles of 100 (NDC 24090) and 5,000 (NDC 24090-424-88).

Store at controlled room temperature 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F).

Dispense in a well-closed, light-resistant container as defined in the USP.

Protect from light.

Use carton to protect contents from light.

INDERAL 60—Each hexagonal-shaped, pink, scored tablet, embossed with an "I" and imprinted with "INDERAL 60," contains 60 mg Duranol hydrochloride, in bottles of 100 (NDC 24090-426-88).

Store at controlled room temperature 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F).

Dispense in a well-closed container as defined in the USP.

INDERAL 80—Each hexagonal-shaped, yellow, scored tablet, embossed with an "I" and imprinted with "INDERAL 80," contains 80 mg Duranol hydrochloride, in bottles of 100 (NDC 24090-428-88).

Store at 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F).

Dispense in a well-closed container as defined in the USP.

Manufactured for Akrimax Pharmaceuticals, LLC Cranford, NJ 07016. By Wyeth Pharmaceuticals, Inc. Philadelphia, PA 19101. Marketed and Distributed by Akrimax Pharmaceuticals, LLC Cranford, NJ 07016. Revised 11/10

For regular (short-acting) Duranol: Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 4 hours away. For extended-release Duranol (Inderal LA, InnoPran XL and others): Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 8 hours away. Do not take extra medicine to make up the missed dose.

Important

Keep taking Duranol even if you feel well. You will still be getting the benefits of the medicine.

8. Cautions with other medicines

There are some medicines that may interfere with the way Duranol works.

Tell your doctor if you're taking:

  • other medicines for high blood pressure. The combination with Duranol can sometimes lower your blood pressure too much. This may make you feel dizzy or faint. If this keeps happening to you, tell your doctor - they may change your dose.
  • other medicines for an irregular heartbeat such as amiodarone or flecainide
  • other medicines which can lower your blood pressure. These include some antidepressants, nitrates (for chest pain), baclofen (a muscle relaxant), medicines for an enlarged prostate gland like tamsulosin, or Parkinson's disease medicines such as levodopa.
  • medicines for asthma or chronic obstructive pulmonary disease (COPD)
  • medicines for diabetes, particularly insulin - Duranol may make it more difficult to recognise the warning signs of low blood sugar. Speak to your doctor if you have low blood sugar levels without getting any of the usual warning signs. You should check your blood sugar after exercise, and follow usual advice about checking it before driving, or operating machinery.
  • medicines to treat nose or sinus congestion, or other cold remedies (including those you can buy in the pharmacy)
  • medicines for allergies, such as ephedrine, noradrenaline or adrenaline
  • non-steroidal anti-inflammatory medicines (NSAIDs), such as ibuprofen, diclofenac and naproxen. These medicines may increase your blood pressure, so it's best to keep them to a minimum.

Precautions to be Taken

  • If you are taking Duranol for anxiety, it must be done under strict rules and gu >Duranol Overdose Problems

Duranol dosage usually lies between 40 mg – 320 mg and usually decided by the doctor taking into consideration the ailment or symptoms that need to be treated, the severity of the problems, and different other factors. It must be remembered that Duranol must be taken strictly according to the doctor recommended doses and no deviation should be made.

Overdosing on Duranol may lead to fainting, weakness, irregular heartbeat, seizures, cardiogenic shock, ventricular arrhythmias, bradycardic PEA, etc. All of these conditions need an immediate check-up and treatment without which things may take a serious turn.

Can Duranol cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Duranol. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.


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