Dclot tablets

Dclot

  • Active Ingredient: Clopidogrel
  • 75 mg
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What is Dclot?

The active ingredient of Dclot brand is clopidogrel. Clopidogrel helps to prevent platelets in your blood from sticking together and forming a blood clot. Unwanted blood clots can occur with certain heart or blood vessel conditions. Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole. Effect of Clopidogrel on other drugs In vitro studies have shown that the glucuronide metabolite of Clopidogrel is a strong inhibitor of CYP2C8. Concomitant administration of repaglinide with Clopidogrel increased the systemic exposure to repaglinide (AUC0-∞) by 5.1-fold following the loading dose (300 mg) and by 3.9-fold on day 3 of the maintenance dose (75 mg) of Clopidogrel [see Drug Interactions (7.5)].

Used for

Dclot is used to treat diseases such as: Acute Coronary Syndrome, Acute Coronary Syndrome, Prophylaxis, Heart Attack, Ischemic Stroke, Ischemic Stroke, Prophylaxis, Percutaneous Coronary Intervention, Peripheral Arterial Disease, Platelet Aggregation Inhibition, Transient Ischemic Attack.

Side Effect

Possible side effects of Dclot include: sores, welting, or blisters; dizziness; difficulty with speaking; red or purple spots on the skin, varying in size from pinpoint to large bruises; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.

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How should this medicine be used?

Dclot comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take Dclot at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dclot exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Dclot will help prevent serious problems with your heart and blood vessels only as long as you take the medication. Continue to take Dclot even if you feel well. Do not stop taking Dclot without talking to your doctor. If you stop taking Dclot, there is a higher risk that you may have a heart attack or stroke. If you have a stent, there is also a higher risk that you could develop a blood clot in the stent if you stop taking Dclot too soon.

The effect of proton pump inhibitors (PPI) on the systemic exposure to the Dclot active metabolite following multiple doses of Plavix 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1.

Figure 1: Exposure to Dclot Active Metabolite Following Multiple Doses of Plavix 75 mg Alone or with Proton Pump Inhibitors (PPIs)

Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole.

Q: Does cranberry juice interfere with Plavix?

A: Plavix (Dclot) hinders the platelets in the blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Plavix is used to prevent blood clots after a recent heart attack or stroke and in people with certain disorders of the heart or blood vessels. As a result of the action of this drug, Plavix can make it easier for bleeding to occur, even from a minor injury. There are no documented medical reports or research studies that have concluded that cranberry juice has any effect on Plavix. There have been some reports that cranberry juice should not be taken with Coumadin (warfarin), because it may lengthen the clotting time even further. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Gregory Latham, RPh

Embryo-fetal developmental toxicology studies were performed in pregnant rats and rabbits with doses up to 500 and 300 mg/kg/day, respectively, administered during organogenesis. These doses, corresponding to 65 and 78 times the recommended daily human dose, respectively, on a mg/m² basis, revealed no evidence of impaired fertility or fetotoxicity due to Dclot.

Q: Is the generic Plavix as effective as the original Plavix? How long should one be on Plavix?

A: Your question concerns Plavix (Dclot) (//www.everydayhealth.com/drugs/plavix). At the present time, there is no generic Dclot available in the United States. While antiplatelet therapy with medications such as Plavix is not usually permanent, it may last for weeks or even many months. It is always a good idea to check with one

Q: Is it recommended to take Plavix after a heart attack and receiving a stent?

A: Stents are used when an artery in the heart is narrowing due to plaque buildup. Stents help to keep the arteries open to reduce the risk of heart attacks. After a stent is put in place, blood thinning medications are used to prevent a blood clot from forming in the stent and blocking the artery. According to the American Heart Association, Plavix and aspirin are used after a stent is placed, as long as there are no contraindications to their use. Aspirin is used indefinitely. Plavix is used for one to twelve months, or even longer, depending on the type of stent that is put in place. Please consult with your health care provider in regards to the length of time you should be on Plavix. Plavix (Dclot) is in a class of medications known as platelet inhibitors. Plavix is used to prevent heart attacks and strokes. Plavix works by stopping the blood clots from forming that may lead to a heart attack or stroke. Aspirin is in a medication class called salicylates. Aspirin, in prescription form, is used to treat symptoms of osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, and other conditions associated with pain and swelling. Over-the-counter aspirin is used to lessen fever and treat pain from a variety of conditions. In addition, over-the-counter aspirin is used to prevent heart attack in people who have had a heart attack or who experience angina; and it is used in the treatment of a heart attack. Over-the-counter aspirin is also used to prevent certain types of strokes. Kristen Dore, PharmD

Salicylates (aspirin)

If you have acute coronary syndrome, you should take aspirin with Dclot. However, you should not take these drugs together if you’ve had a recent stroke. Doing so increases your risk of major bleeding.

Advertencia:

El Dclot se debe cambiar a una forma activa en el cuerpo para que pueda tratar su condiciГіn. Algunas personas no cambian el Dclot a la forma activa dentro del cuerpo tan bien como otras personas. Debido a que el medicamento no funciona tan bien en estas personas, podrГ­an estar en un riesgo mayor de sufrir un infarto o un derrame cerebral. Existen pruebas disponibles para identificar a las personas que tienen problemas para cambiar el Dclot a una forma activa. Hable con su mГ©dico sobre si usted debe hacerse el examen. Si se determina que tiene dificultad para convertir el Dclot a la forma activa, su mГ©dico probablemente tenga que cambiarle la dosis Dclot o indicarle que no lo tome.

Su mГ©dico o farmacГ©utico le darГЎ la hoja de informaciГіn del fabricante para el paciente (GuГ­a del medicamento) cuando inicie su tratamiento con Dclot y cada vez que vuela a surtir su receta mГ©dica. Lea la informaciГіn atentamente y pregunte a su mГ©dico o farmacГ©utico si tiene alguna duda. TambiГ©n puede visitar el sitio web de la AdministraciГіn de Drogas y Alimentos (Food and Drug Administration, FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) o el sitio web del fabricante para obtener la GuГ­a del medicamento.

Hable con su mГ©dico sobre los riesgos de tomar Dclot.

What are some other side effects of Dclot?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

There are no data on the presence of Dclot in human milk or the effects on milk production. No adverse effects on breastfed infants have been observed with maternal Dclot use during lactation in a small number of postmarketing cases. Studies in rats have shown that Dclot and/or its metabolites are present in the milk. When a drug is present in animal milk, it is likely that the drug will be present in human milk. The developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for PLAVIX and any potential adverse effects on the breastfed infant from PLAVIX or from underlying maternal condition.

Hypersensitivity

Plavix is contraindicated in patients with hypersensitivity (e.g., anaphylaxis) to Dclot or any component of the product .

Pregnancy and breastfeeding

Dclot is not recommended if you're pregnant or breastfeeding. This is because there's very little information on its use in pregnant and breastfeeding women.

Dclot can cause side effects, although serious reactions are rare.

Common side effects of Dclot can include:

  • headaches or dizziness
  • nausea
  • diarrhoea or constipation
  • indigestion (dyspepsia)
  • stomach ache or abdominal pain
  • nosebleeds
  • increased bleeding (your blood taking longer to clot – for example, when you cut yourself), or easy bruising

Speak to your GP if any of these side effects get worse or don't go away.

Although Dclot is unlikely to affect your ability to drive, some people may feel dizzy when taking it. Avoid driving if you feel dizzy.

Repaglinide (CYP2C8 Substrates)

The acyl-β-glucuronide metabolite of Dclot is a strong inhibitor of CYP2C8. Plavix can increase the systemic exposure to drugs that are primarily cleared by CYP2C8, thereby needing dose adjustment and appropriate monitoring.

Plavix increased repaglinide exposures by 3.9-fold to 5.1-fold . Avoid concomitant use of repaglinide with Plavix. If concomitant use cannot be avoided, initiate repaglinide at 0.5 mg before each meal and do not exceed a total daily dose of 4 mg. Increased frequency of glucose monitoring may be required during concomitant use.

Blood thinners

Warfarin and Dclot work to thin the blood in different ways. Taking them together increases your risk of bleeding.


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