Q: I have been diagnosed with hardening of the arteries and I am taking Plavix. Is there anything I can do to reverse my situation?
A: Plavix (Clodian), an oral antiplatelet agent, is used to inhibit blood clots in patients with coronary artery disease, peripheral vascular disease, and cerebrovascular disease. In clinical trials, the most common side effects of Plavix were severe itching (pruritus), a severe rash characterized by the appearance of purplish spots or patches (purpura), diarrhea, and rash. According to the literature, patients who lowered LDL ("bad") cholesterol with statin drugs to about 60 mg/dL, on average, regressed plaques (reduced plaque in the coronary arteries). Reducing LDL cholesterol to low levels is important and is the cornerstone of therapy. Raising HDL ("good") cholesterol appears to be equally important. In addition, regular exercise and controlling blood pressure has been shown to dramatically benefit heart patients. In summary, if you keep your LDL down, your HDL up, avoid smoking, exercise regularly, and control your blood pressure, you have a good chance at slowing or reversing the buildup of plaque in your arteries. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Shereen A. Gharbia, PharmD
Most pharmacies stock the generic form of Clodian. However, not every pharmacy stocks Plavix, the brand-name form. If your doctor prescribes Plavix, when filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Q: Can Plavix cause blood vessels to break in the eye?
A: Plavix (Clodian) is a medication that is used to prevent blood clots. It keeps the platelets in your blood from clotting to prevent unwanted blood clots in patients with heart or blood vessel conditions. The prescribing information for Plavix does list eye disorders such as conjunctival (white part of the eye), ocular, and retinal bleeding as side effects of this medication. If you experience any type of bleeding in the eye, you should consult with your physician to be sure damage is not being done to your eyesight. Lori Poulin, PharmD
Q: My pharmacy wanted to give me a new generic medicine - Grepid, Clodian, instead of Plavix, which I have bought until now. This Grepid was so much cheaper I was told, but I don't know if I dare. I have had two apoplexies and two TIAs since 1992.
A: Unfortunately we
El Clodian puede ocasionar efectos secundarios. Informe a su mГ©dico si cualquiera de estos sГntomas es fuerte o no desaparece:
- cansancio excesivo
- dolor de cabeza
- dolor de estГіmago
- sangrado de nariz
In vitro studies have shown that the glucuronide metabolite of Clodian is a strong inhibitor of CYP2C8. Concomitant administration of repaglinide with Plavix increased the systemic exposure to repaglinide (AUC0-∞) by 5.1-fold following the loading dose (300 mg) and by 3.9-fold on day 3 of the maintenance dose (75 mg) of Plavix .
What Is Clodian and How Does It Work?
Clodian is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
Clodian works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.
Clodian is available under the following different brand names: Plavix.
Dosages of Clodian:
Dosage Forms and Strengths
Dosage Considerations – Should be Given as Follows:
Unstable angina, non-ST-segment elevation heart attack (myocardial infarction ) (NSTEMI): 300 mg loading dose; initiating therapy without a loading dose will delay establishment of antiplatelet effect by several days; following the loading dose, administer 75 mg/day orally for up to 12 months; may administer beyond 12 months if used in combination with aspirin (75-100 mg/day); long-term combination therapy with aspirin, following stent placement, is individualized depending on how a patient tolerates long-term dual antiplatelet therapy (DAPT), whether they have stable coronary artery disease, and do NOT have risk factors (e.g., transient ischemic attack or stroke, age over 75 years, bleeding risk, low body weight, concurrent medications)
ST-segment elevation myocardial infarction (MI) (STEMI): 75 mg/day orally in combination with aspirin 162-325 mg/day and then 81-162 mg/day
Age under 75 years
- 300 mg loading dose followed by 75 mg for 14 days up to 12 months (if no bleeding)
- Concomitant therapy with aspirin: Administer in combination with aspirin 75-325 mg once/day with or without thrombolytics
Age over 75 years
- No loading dose
- 75 mg for 14 days up to 12 months (if no bleeding)
Recent heart attack (Myocardial Infarction ), Stroke, or Established Peripheral Arterial Disease
- 75 mg orally once/day without a loading dose; recommended as alternative to aspirin or concomitantly with aspirin if patient not at increased risk for bleeding but at high risk for cardiovascular disease
- Prophylaxis if patient not candidate for oral anticoagulation
- 75 mg/day orally
- Renal impairment: Dose adjustment not necessary
- Hepatic impairment: Use caution; experience limited
- CYP2C19 poor metabolizers associated with diminished antiplatelet response to Clodian; although higher-dose regimen (600 mg loading dose followed by 150 mg once daily) in poor metabolizers increases antiplatelet response, no appropriate dosing regimen for poor metabolizers has been established in clinical outcome trials
- Not recommended for pediatric use
Q: I had a stent put in my artery on 2007. I take everyday one tablet of Plavix 75 mg. Fow how long must I take the Plavix?
A: The recommended daily dose of Plavix (Clodian) is 75 mg once daily, indefinitely or until your physician says otherwise. Did you know that a generic does exist? For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
How should I take Clodian?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use these medicines exactly as directed.
Clodian can be taken with or without food.
Clodian is sometimes taken together with aspirin. Take aspirin only if your doctor tells you to.
Clodian keeps your blood from coagulating (clotting) and can make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.
You may need to stop using Clodian for a short time before a surgery, medical procedure, or dental work. Any healthcare provider who treats you should know that you are taking Clodian.
Do not stop taking Clodian without first talking to your doctor, even if you have signs of bleeding. Stopping the medicine could increase your risk of a heart attack or stroke.
Store at room temperature away from moisture and heat.
Q: I was placed on Plavix following a headache; however, it was not a stroke. I have been using it for a year. I am 67-year-old female. Will I have to always take it?
A: Your question regards Plavix (Clodian) //www.everydayhealth.com/drugs/plavix According to Lexi-Comp, Plavix is used to help prevent the clotting of platelets in your blood. It is usually used in patients that have a history of heart attack or stroke or in patients that have certain disorders of their blood vessels. I would speak to your prescribing physician regarding why you were put on the medication. Patients that are being treated for the above uses, will likely be on the medication for the long duration. Your physician could provide information about your treatment duration. Jen Marsico, RPh
Algunos efectos secundarios pueden ser graves. Si experimenta alguno de los sГntomas siguientes, llame a su mГ©dico inmediatamente:
- dificultad para respirar o tragar
- inflamaciГіn del rostro, garganta, lengua, labios, ojos, manos, pies, tobillos o parte inferior de las piernas
- heces negras y alquitranadas
- sangre roja en las heces
- vГіmito con sangre
- vГіmito que se ve como cafГ© molido
- moretones o sangrado inusuales
- orina rosada o marrГіn
- dificultad para hablar o hablar lento
- debilidad u hormigueo de un brazo o una pierna
- cambios en la visiГіn
- dificultad para respirar
- ritmo cardiaco rГЎpido
- piel pГЎlida
- parches morados o sangrado debajo de la piel
- amarilleamiento de la piel o los ojos
El Clodian puede ocasionar otros efectos secundarios. Llame a su mГ©dico si tiene algГєn problema inusual mientras toma este medicamento.
Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgaciГіn de efectos adversos 'MedWatch' de la AdministraciГіn de Alimentos y Medicamentos (FDA, por su sigla en inglГ©s) en la pГЎgina de Internet (http://www.fda.gov/Safety/MedWatch) o por telГ©fono al 1-800-332-1088.
Before taking this medicine
You should not use Clodian if you are allergic to it, or if you have:
any active bleeding; or
a stomach ulcer or bleeding in the brain (such as from a head injury).
Tell your doctor if you have ever had:
an ulcer in your stomach or intestines; or
a bleeding disorder or blood clotting disorder.
Clodian may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Clodian is right for you.
This medicine is not expected to harm an unborn baby. However, taking Clodian within 1 week before childbirth can cause bleeding in the mother. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breast-feed while using this medicine.
Clodian is metabolized to its active metabolite in part by CYP2C19. Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of Clodian and a reduction in platelet inhibition .
There are no data on the presence of Clodian in human milk or the effects on milk production. No adverse effects on breastfed infants have been observed with maternal Clodian use during lactation in a small number of postmarketing cases. Studies in rats have shown that Clodian and/or its metabolites are present in the milk. When a drug is present in animal milk, it is likely that the drug will be present in human milk. The developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for PLAVIX and any potential adverse effects on the breastfed infant from PLAVIX or from underlying maternal condition.