Q: I take Plavix and have GERD. Zantac 300 mg is no longer helping my heartburn. What can I take with Plavix?
A: Treating heartburn and GERD can be tricky in patients taking Plavix (Clavix) because of drug interactions with the medications used to treat those symptoms. H2 Blockers, the class of drugs that includes Zantac (ranitidine), are okay to use. The exception is cimetidine which will interact with Plavix. The other main class of drugs used to treat GERD is the proton pump inhibitors (PPIs). The FDA has released a safety bulletin about using omeprazole, a PPI, with Plavix. This combination results in decreased effectiveness of Plavix, increasing the risk of heart attack or stroke. It is unclear if the other PPI drugs have the same effect and if it is to the same extent. Over-the-counter (OTC) antacids, such as Tums, may help somewhat. Always read and follow the complete directions and warnings on OTC medications and discuss their use with your healthcare provider before taking them. Contact your healthcare provider to discuss your treatment options. You may also find helpful information at //www.everydayhealth.com/drugs/plavixSarah Lewis, PharmD
What is clop >
Clavix is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.
Clavix may also be used for purposes not listed in this medication guide.
Clavix may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- excessive tiredness
- stomach pain
Warnings for other groups
For pregnant women: Studies done in pregnant women taking Clavix have not shown an increased risk of birth defects or miscarriage. Studies of Clavix in pregnant animals also have not shown these risks.
However, there are potential risks to the mother and fetus if a heart attack or stroke occurs during pregnancy. Therefore, the benefit of Clavix in preventing these health events may outweigh any risk of the drug on the pregnancy.
Tell your doctor if you’re pregnant or plan to become pregnant. Clavix should be used during pregnancy only if the potential benefit justifies the potential risk.
For women who are breastfeeding: It isn’t known if Clavix passes into breastmilk. If it does, it may cause serious effects in a child who is breastfed. You and your doctor may need to decide if you’ll take Clavix or breastfeed.
For children: The safety and effectiveness of Clavix hasn’t been established in children younger than 18 years.
Clavix oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug or don’t take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
If you have to temporarily stop taking Clavix, start taking it again as soon as your doctor tells you to. Stopping this drug may increase your risk of serious heart conditions, stroke, or a blood clot in the legs or lungs.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include bleeding.
If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: If you miss a dose, take Clavix as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Take only one dose at your regular time. Don’t take two doses of Clavix at the same time unless your doctor tells you to.
How to tell if the drug is working: You should not have a heart attack or stroke.
Keep these considerations in mind if your doctor prescribes Clavix oral tablet for you.
Mechanism Of Action
Clavix is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
Plavix is contraindicated in patients with hypersensitivity (e.g., anaphylaxis) to Clavix or any component of the product .