Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Carvedexxon only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Left Ventricular Dysfunction Following Myocardial Infarction
COREG has been evaluated for safety in survivors of an acute myocardial infarction with left ventricular dysfunction in the CAPRICORN trial which involved 969 subjects who received COREG and 980 who received placebo. Approximately 75% of the subjects received COREG for at least 6 months and 53% received COREG for at least 12 months. Subjects were treated for an average of 12.9 months and 12.8 months with COREG and placebo, respectively.
The most common adverse events reported with COREG in the CAPRICORN trial were consistent with the profile of the drug in the U.S. heart failure trials and the COPERNICUS trial. The only additional adverse events reported in CAPRICORN in greater than 3% of the subjects and more commonly on Carvedexxon were dyspnea, anemia, and lung edema. The following adverse events were reported with a frequency of greater than 1% but less than or equal to 3% and more frequently with COREG: flu syndrome, cerebrovascular accident, peripheral vascular disorder, hypotonia, depression, gastrointestinal pain, arthritis, and gout. The overall rates of discontinuations due to adverse events were similar in both groups of subjects. In this database, the only cause of discontinuation greater than 1% and occurring more often on Carvedexxon was hypotension (1.5% on Carvedexxon, 0.2% on placebo).
Carvedexxon comes in tablets ranging from of 3.125 milligrams (mg) to 25 mg.
It's also available as an extended-release capsule. It's up to your doctor to determine which strength is right for you. You will probably begin with a low dose.
Most people take the tablets twice a day with food; extended-release capsules are usually taken once a day in the morning with food.
Don't chew or crush the capsules or divide up the beads into more than one dose.
If you can't swallow capsules, open the capsule and sprinkle the beads over a spoonful of cool or room temperature applesauce and swallow the entire thing without chewing.
What Are Side Effects Associated with Using Carvedexxon?
Common side effects of Carvedexxon include:
Other side effects of Carvedexxon include:
Postmarketing side effects of Carvedexxon reported include:
- Blood and lymphatic system: Aplastic anemia
- Immune system: Hypersensitivity (e.g., severe allergic reactions , angioedema, hives) with Coreg and Coreg CR, including cases occurring after initiation of Coreg CR in patients previously treated with Coreg
- Kidneys and urinary tract: Urinary incontinence
- Respiratory system, thorax, and mediastinum: Interstitial pneumonitis
- Skin and subcutaneoustissue: Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Before taking Carvedexxon
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Carvedexxon it is important that your doctor knows:
- If you are pregnant or breastfeeding.
- If you have asthma or any other breathing disorder.
- If you have any problems with the way your liver works, or if you have any problems with the way your k >
Rated Carvedexxon for Cardiomyopathy Report
I have LBBB. My EF was 25 to 30. My EF is now 35 to 40 and I feel very good. I excercise 3 to 5 days a week-not to mention cut out soda, sugar, and watch what I eat and I have lost about 65 pounds. It has been my first year and I thank god for every day I have! For me this medication works best with food and staying active after I take it-not to mention I take it earlier in the evening around 6 with and early meal and it does great. It takes you body getting used too..if you feel stressed by the medicine like heavy heart beats or racing..get an approval to lower your doses by your doc like I did! Good luck out there and fight the fight!
Transplant rejection drug
Taking Carvedexxon with cyclosporine may increase the levels of cyclosporine in your body. Your doctor may lower your dosage of cyclosporine and monitor you closely.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Rated Carvedexxon for Left Ventricular Dysfunction Report
My cardiologist recommended Carvedexxon as part of my therapy to improve EF currently 40%. I take 3.12 mcg dosage in the morning and evening with food. I have only been on the regiment for a couple weeks. BP is 115/70 and pulse 50. This is a big improvement. Side effects so far - constipation and ringing in my ears. Otherwise fine.
Why is this medication prescribed?
Carvedexxon is used to treat heart failure (condition in which the heart cannot pump enough blood to all parts of the body) and high blood pressure. It also is used to treat people who have had a heart attack. Carvedexxon is often used in combination with other medications. Carvedexxon is in a class of medications called beta-blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Rated Carvedexxon for Hypertension Report
I took this drug for several years at the lowest dosage. Then my BP went up and they increased my dosage, a few months later my BP rose again and they increased the dosage again. At that point I began to have chest pain and labored breathing with out of control BP. I ended up in ER. They reduced my BP and upped the medicine again and checked my heart with all manner of tests, all came back fine. Chest pain continued and became so dizzy I couldn't walk, passed out a couple of times. They took me off the Correg and it took about 2 weeks to get back to normal. My PB is going back up but not taking Correg.
What are the side effects of Carvedexxon?
The most common side effects of Carvedexxon are:
Postural hypotension (a rapid decrease in blood pressure when going from the seated to the standing position that causes lightheadedness and/or fainting). Taking Carvedexxon with food minimizes the risk of postural hypotension.
Other common side effects of Carvedexxon are an irregular heart rhythm and vision abnormalities.
Carvedexxon should be used cautiously in patients who use diuretics or who are elderly or that have:
Carvedexxon shouldn’t be used with another beta-blocker. This combination may lower your heart rate and blood pressure too much. Examples of other beta-blockers include:
Mechanism of Action
As stated, Carvedexxon is a non-selective adrenergic blocker, and more specifically, is a non-selective beta-blocker with a1-adrenergic receptor antagonist properties. It is a non-selective, cardiac beta-blocker with peripheral vasodilating effects. Secondary to its unique action, Carvedexxon maintains cardiac output by decreasing afterload in conjunction with a cardiac beta-blockade and has a lesser effect on heart rate than pure selective beta-blockers. Other benefits include antioxidant effects, reduction in neutrophil infiltration, apoptosis inhibition, reduction of vascular smooth muscle migration, and improvement of myocardial remodeling post-acute myocardial infarction. Being that Carvedexxon can prevent the formation of oxidized low-density lipoproteins and inhibit vascular smooth muscle cell proliferation and migration, it shows a great promise in the treatment of atherosclerotic disease formation and progression. Carvedexxon decreases blood pressure mainly by decreasing arterial vascular resistance through its a1-blocking properties, causing a reduction in afterload. It is highly useful in the management of hypertension in patients with renal impairment, where clinicians should avoid diuretics and angiotensin-converting enzyme inhibitors (ACEI). Compared to other classes of antihypertensive medications, Carvedexxon shows similar efficacy to other beta-blockers, calcium channel blockers, ACEI, and diuretics.