Cardiover tablets


  • Active Ingredient: Verapamil
  • 240 mg, 120 mg, 80 mg
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What is Cardiover?

The active ingredient of Cardiover brand is verapamil. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy α-(1-methylethyl) hydrochloride Verapamil hydrochloride, USP is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Verapamil hydrochloride is not chemically related to other cardioactive drugs. Inactive ingredients include calcium sulfate, colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate, talc and titanium dioxide.

Used for

Cardiover is used to treat diseases such as: Angina, Arrhythmia, Bipolar Disorder, Cluster Headaches, High Blood Pressure, Idiopathic Hypertrophic Subaortic Stenosis, Migraine Prevention, Nocturnal Leg Cramps, Supraventricular Tachycardia.

Side Effect

Possible side effects of Cardiover include: Acid or sour stomach; slow or irregular heartbeat; swelling in legs and ankles; confusion; Blue lips and fingernails; coughing that sometimes produces a pink frothy sputum.

How to Buy Cardiover tablets online?

To purchase Cardiover online - simply click on the "Buy Now" button in the top and follow on to our store. Payment and Order takes a couple of minutes, and all steps are obvious. We don't take a medical prescription plus also we have many methods of payment. With all the details of fast shipping and confidentiality, you can read on the relevant pages on the hyperlinks in the top menu.

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ВїCГіmo se debe usar este medicamento?

La presentaciГіn del Cardiovero es en tabletas, tabletas de liberaciГіn prolongada (acciГіn prolongada) y cГЎpsulas de liberaciГіn prolongada (acciГіn prolongada), para administrarse por vГ­a oral. Por lo general, la tableta comГєn se toma de tres a cuatro veces al dГ­a. Por lo general, las tabletas y las cГЎpsulas de liberaciГіn prolongada se toman una o dos veces al dГ­a. Tome el Cardiovero aproximadamente a la misma hora todos los dГ­as. Determinados productos con Cardiovero deben tomarse por la maГ±ana y, otros, a la hora de acostarse. Consulte a su mГ©dico cuГЎl es el mejor momento para que tome su medicamento. Siga atentamente las instrucciones de la etiqueta de la receta y pГ­dales a su mГ©dico o a su farmacГ©utico que le expliquen cualquier cosa que no entienda. Tome el Cardiovero segГєn lo indicado. No aumente ni disminuya la dosis, ni la tome con mГЎs frecuencia que la indicada por su mГ©dico.

Trague las tabletas y las cГЎpsulas de liberaciГіn prolongada enteras. No las mastique ni las triture. PregГєntele a su farmacГ©utico si las tabletas se pueden partir por la mitad, dado que las instrucciones varГ­an segГєn el producto.

Si no puede tragar las cГЎpsulas de liberaciГіn prolongada, puede abrirlas con cuidado y espolvorear todo el contenido en una cucharada de compota de manzana. La compota de manzana no debe estar caliente, y debe estar lo suficientemente blanda para que se pueda tragar sin masticar. Trague la compota de manzana inmediatamente sin masticarla y, luego, beba un vaso de agua frГ­a para asegurarse de haber tragado todo el medicamento. No almacene la mezcla para usarla mГЎs tarde.

Es probable que, al principio, su mГ©dico le recete una dosis baja de Cardiovero y la aumente en forma gradual.

El Cardiovero controla las arritmias, la presiГіn arterial alta y la angina, pero no cura estas afecciones. Siga tomando Cardiovero aunque se sienta bien. No deje de tomar Cardiovero sin consultar a su mГ©dico.

Cardiover is a calcium channel blocker that is used to treat high blood pressure (hypertension), severe chest pain (angina), and irregular heart rhythms (arrhythmia). It may also be used as a migraine prevention medication, although it has not been approved by the U.S. Food and Drug Administration for that purpose. This is called “off label usage.” Many times, doctors learn of new research showing a medication is effective in treating a condition and prescribe it for their patients who have exhausted available FDA-approved treatment options.

Cardiover is sold under the brand names Verelan ® , Verelan ® PM, Calan ® , and Calan ® SR.

Warnings for other groups

For pregnant women: Cardiover is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the unborn baby.

Using Cardiover during pregnancy may cause negative effects in the fetus such as low heart rate, low blood pressure, and abnormal heart rhythm. Tell your doctor if you’re pregnant or plan to become pregnant. Cardiover should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

For women who are breastfeeding: Cardiover passes through breast milk. It may cause negative effects in a breastfeeding baby. Talk with your doctor before breastfeeding while taking this medication.

For children: The safety and effectiveness of Cardiover haven’t been established in people younger than 18 years old.

What Is Cardiover (Calan, Covera HS, Isoptin SR, Verelan)?

Calan, Covera HS, Isoptin SR, Verelan are the brand names of the drug Cardiover, which is used to treat high blood pressure and control chest pain known as angina.

The immediate-release tablet form of this medication is also used to prevent and treat irregular heartbeats (arrhythmia).

Although this medicine is not approved by the FDA for migraines, it is often prescribed for preventing them.

Cardiover is in a class of drugs called calcium channel blockers. It works by relaxing blood vessels so the heart doesn't have to work as hard, increasing the supply of blood and oxygen to the heart, and slowing electrical activity in the heart to control heart rate.

Cardiover was approved by the Food and Drug Administration (FDA) in 1981.

The drug comes as a tablet, an extended-release tablet, and an extended-release capsule to take by mouth and injectable solution.

Cardiover is on the World Health Organization's "List of Essential Medicines," a list of the most important drugs needed in a basic health care system.

Q: I take Cardiover ER tabs. Is it true that after years of taking high blood pressure medicine it can enlarge your aorta?

A: Cardiover HCl ER (brand names Calan, Verelan) belongs to the group of medications known as calcium channel blockers. Cardiover works to keep blood vessels open, making it easier for the heart to pump blood through the body. Cardiover ER is an extended-release form of Cardiover that is used to treat high blood pressure. The prescribing information does not specifically list enlarged aorta as a possible long-term side effect of Cardiover use. The aorta is the large blood vessel that comes out of the heart to deliver blood to the body. The aorta can become enlarged at any point over its 2- to 3-foot length. Enlargement of the aorta is generally caused by conditions that change the properties of the blood vessel wall. The most common causes are cigarette smoking, high blood pressure (or hypertension), and high cholesterol levels. Genetics (meaning your family history) may also play a role. Controlling blood pressure and obtaining appropriate evaluations and diagnostic tests by your healthcare provider is the best way to prevent the aorta from getting larger over time. Michelle McDermott, PharmD

Is Cardiover safe to take if I'm pregnant or breastfeeding?

Safety of Cardiover during pregnancy has not been established. Cardiover crosses the placenta and enters the fetus.

Safety in nursing mothers has not been established. Cardiover is excreted in human milk.


Treat all Cardiover overdoses as serious and maintain observation for at least 48 hours (especially sustained-release Cardiover products), preferably under continuous hospital care. Delayed pharmacodynamic consequences may occur with the sustained-release formulations. Cardiover is known to decrease gastrointestinal transit time.

Treatment of overdosage should be supportive. Beta-adrenergic stimulation or parenteral administration of calcium solutions may increase calcium ion flux across the slow channel and have been used effectively in treatment of deliberate overdosage with Cardiover. In a few reported cases, overdose with calcium channel blockers has been associated with hypotension and bradycardia, initially refractory to atropine but becoming more responsive to this treatment when the patients received large doses (close to 1 gram/hour for more than 24 hours) of calcium chloride. Cardiover cannot be removed by hemodialysis. Clinically significant hypotensive reactions or high degree AV block should be treated with vasopressor agents or cardiac pacing, respectively. Asystole should be handled by the usual measures including cardiopulmonary resuscitation.

Cardiover Warnings

This medicine controls high blood pressure, arrhythmia, and angina, but it does not cure these conditions. You should continue to take Cardiover even if you feel well.

Before taking Cardiover, tell your doctor if you have or have ever had:

  • Any condition that causes food to move through your digestive system more slowly
  • Myasthenia gravis (a condition that causes certain muscles to weaken)
  • Heart failure
  • Heart, liver, or kidney disease
  • Muscular dystrophy (an inherited disease that causes weakening of the muscles).

You should also tell your doctor you are taking Cardiover before any type of surgery, including dental procedures.

Your doctor will likely start you on a low dose of Cardiover and then gradually increase your dose.

You should keep all appointments with your doctor while taking this medicine. You will need your blood pressure checked regularly to determine how you are responding to Cardiover.

If you take a certain version of the extended-release tablets, you might notice an empty tablet shell in your stool. This does not mean that you did not receive your complete dose of medication.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, clonidine, disopyramide, dofetilide, dolasetron, fingolimod, lithium.

Other medications can affect the removal of Cardiover from your body, which may affect how Cardiover works. Examples include erythromycin, rifamycins (such as rifampin), ritonavir, St. John's wort, among others.

Cardiover can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include asunaprevir, colchicine, flibanserin, ivabradine, lomitapide, midazolam, triazolam, among others.

Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

  • Heart problems warning: Avo >

Cardiover oral capsule is a prescription medication that’s available as the brand-name drugs Verelan PM (extended-release) and Verelan (delayed-release). The extended-release oral capsule is also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand.

Cardiover is also available as an extended-release oral tablet (Calan SR) and an immediate-release oral tablet (Calan). Both forms of these tablets are also available as generic drugs.

Drug–drug interactions

Cardiover has a marked negative inotropic effect and can cause refractory cardiogenic shock, particularly when it is used in combination with a beta-blocker, as combination that is generally to be avoided (43 AR ) .

Cardiover toxicity has been attributed to inhibition of Cardiover metabolism by telithromycin (44 AR ) .

A 76-year-old white woman taking Cardiover 180 mg/day for hypertension took telithromycin 800 mg/day for 2 days for acute sinusitis and became short of breath, weak, profoundly hypotensive and bradycardic, with a systolic blood pressure of 50–60 mmHg and a heart rate of 30/minute. She recovered after drug withdrawal and supportive measures.

Telithromycin is a substrate of CYP3A4 and presumably inhibited the metabolism of Cardiover.


  • This medication contains Cardiover
  • Do not take Isoptin SR, Calan SR, Covera HS, Isoptin, Isoptin IV, Calan, Verap, Cardiover SR, Verelan, or Verelan PM if you are allergic to Cardiover or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

Elevated Liver Enzymes

Elevations of transaminases with and without concomitant elevations in alkaline phosphatase and bilirubin have been reported. Such elevations have sometimes been transient and may disappear even in the face of continued Cardiover treatment. Several cases of hepatocellular injury related to Cardiover have been proven by rechallenge; half of these had clinical symptoms (malaise, fever, and/or right upper quadrant pain) in addition to elevation of SGOT, SGPT, and alkaline phosphatase. Periodic monitoring of liver function in patients receiving Cardiover is therefore prudent.

How to use Cardiover HCL

Take this medication by mouth with or without food as directed by your doctor, usually 3 or 4 times daily.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

For the treatment of high blood pressure, it may take a week before you get the full benefit of this drug. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

To prevent chest pain, it is very important to take this medication regularly as prescribed. This drug should not be used to treat chest pain when it occurs. Use other medications to relieve sudden attacks as directed by your doctor (for example, nitroglycerin tablets placed under the tongue). Consult your doctor or pharmacist for details.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Tell your doctor if your condition does not get better or if it gets worse (for example, your blood pressure readings remain high or increase or your chest pain occurs more often).

Migraine drug

  • eletriptan

Don’t take eletriptan with Cardiover. Cardiover can increase the amount of eletriptan in your body to 3 times as much. This can lead to toxic effects. Don’t take eletriptan for at least 72 hours after you take Cardiover.

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