Cardiacin tablets


  • Active Ingredient: Digoxin
  • 0.25 mg
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What is Cardiacin?

The active ingredient of Cardiacin brand is digoxin. Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm.

Used for

Cardiacin is used to treat diseases such as: Atrial Fibrillation, Heart Failure.

Side Effect

Possible side effects of Cardiacin include: night blindness; vomiting; Black, tarry stools; rash; Chest pain or discomfort; fast, pounding, or irregular heartbeat or pulse; expressed fear of impending death.

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Proton pump inhibitors

Taking Cardiacin with proton pump inhibitors (PPIs) can increase the levels of Cardiacin in your body. If you need to take these drugs with Cardiacin, your doctor may need to adjust your Cardiacin dosage.

Examples of PPIs include:

  • rabeprazole
  • esomeprazole
  • lansoprazole
  • omeprazole


Taking Cardiacin with nefazodone can increase Cardiacin levels in your body. If you need to take this drug with Cardiacin, your doctor will likely reduce your Cardiacin dosage first. They may also monitor your Cardiacin levels during your treatment with nefazodone.

Do any foods or other medicines affect how Cardiacin works?

Some medicines and foods can decrease the amount of Cardiacin your body absorbs. These include:

  • Antacids that contain aluminum or magnesium.
  • Some cholesterol-lowering medicines (cholestyramine and colestipol).
  • Certain medicines that treat gastrointestinal issues, such metoclopramide or sulfasalazine.
  • Some antidiarrheal medicines that contain kaolin and pectin.
  • Bulk laxatives (such as psyllium, Metamucil or Citrucel).
  • High-fiber foods (such as bran muffins) or nutritional supplements (such as Ensure).

Don’t take these medicines or eat high-fiber foods too close to the time you take your Cardiacin. It could mean that you’ll have too little Cardiacin in your bloodstream to help your heart. It is better to take Cardiacin on an empty stomach. Check with your doctor before taking any of the medicines listed above. If your doctor says it’s okay to take these medicines, wait 2 hours between a dose of Cardiacin and a dose of these medicines.

Cardiacin interacts with many other medicines, too. You should always tell your doctor and your pharmacist about all the medicines you are taking. This includes any over-the-counter medicines, natural remedies, and herbal medicines. Always talk to your doctor before you take any new medicines.


The following adverse reactions are included in more detail in the Warnings and Precautions section of the label:

  • Cardiac arrhythmias
  • Cardiacin Toxicity

Pregnancy and Cardiacin

Cardiacin should only be taken by pregnant women when the risks outweigh the benefit.

Talk to your doctor if you are pregnant or might become pregnant before taking this medication.

Cardiacin has been found to pass into breast milk, so talk to your doctor if you are breastfeeding or plan to breastfeed.

Cardiacin and Alcohol

Cardiacin can cause sleepiness, confusion, and problems with balance; drinking while taking Cardiacin could worsen these side effects.

For best results, avoid drinking alcohol while taking Cardiacin.


Do not share this medication with others.

Lab and/or medical tests (such as Cardiacin levels, mineral levels in the blood, kidney function tests, electrocardiograms) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Check your blood pressure and pulse (heart rate) regularly while taking this medication. Learn how to check your own blood pressure and pulse at home, and share the results with your doctor.

Elsewhere On The Web

Sources Used in Current Review

2016 review by Nicholas Heger, PhD, CC (NRCC), Assistant Director - Clinical Chemistry, Tufts Medical Center Boston.

Yancy CW, Jessup M, Bozkurt B, et al. American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16):e240-e327.

Baselt, Randall C. (©2014). Disposition of Toxic Drugs and Chemicals in Man 10th edition: Biomedical Publications, Seal Beach, CA. Pp 656-659.

Bilbault P1, Oubaassine R, Rahmani H, Lavaux T, Castelain V, Sauder P, Schneider F. Emergency step-by-step specific immunotherapy in severe Cardiacin poisoning: an observational cohort study. Eur J Emerg Med. 2009 Jun;16(3):145-9.

Brent, Jeffrey; Wallace, Kevin; Burkhart, Keith; Phillips, Scott and Donovan, J. Ward. (© 2005). Critical Care Toxicology – Diagnosis and Management of the Critically Poisoned Patient, 1st edition. Mosby, Inc., Philadelphia, PA. Pp. 1325-1333.

Sources Used in Previous Reviews

Clinical Chemistry: Principles, Procedures, and Correlations. Bishop M, Duben-Engelkirk J, Fody E, eds. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2000.

Sacher RA, McPherson RA, Campos J. Widmann's Clinical Interpretation of Laboratory Tests. 11th ed. Philadelphia: F.A. Davis Company; 2000.

Goodman & Gilman's The Pharmacological Basis Of Therapeutics. 11th Edition. Lazo J, Goodman L S, Parker K L, eds, McGraw-Hill, September 2005.

National Heart, Lung, and Blood Institute (September 2003). Heart and Vascular Diseases: Heart Failure: Summary page (On line information). Available onlin at

Terra, S G, Washam J B, Dunham, G D, and Gattis W A, (Oct 1999). Therapeutic Range of Cardiacin's Efficacy in Heart Failure: What Is the Evidence? Pharmacotherapy, 19(10): 1123-1126, (On line journal). Available online at

Gibbs C R, Davies M K Davies, Lip G Y H, (Feb 2000). Management: Cardiacin and other inotropes, Beta-blockers, and antiarrhythmic and antithrombotic treatment, BMJ. 320(7233): 495-498. PDF available for download at >

Mihai Gheorghiade, MD; Kirkwood F. Adams, Jr, MD; Wilson S. Colucci, MD (2004). Cardiacin in the Management of Cardiovascular Disorders, Circulation; 109:2959-2964 (On line journal). Available online through

Rich, M. (2003 September). Drug Therapy of Heart Failure in the Elderly. Am J Geriatr Cardiol 12(4):235-242 (On line journal). Available online at

Yusuf, S (November 1997). Cardiacin in heart failure: results of the recent Cardiacin investigation group trial in the context of other treatments for heart failure Eur Heart J, 18: 1685-1688. PDF available for download through

The Digitalis Investigation Group, (February 1997). The Effect Of Cardiacin on Mortality and Morbidity in Patients with Heart Failure, NEJM volume 336:525-533 (On line journal). Available online at

Catherine A. Hammett-Stabler, PhD, DABCC, FACB. Pathology and Laboratory Medicine, UNC-Chapel Hill.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 361-364.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 1334-1335.

What is the dosage for Cardiacin?

  • Cardiacin may be taken with or without food.
  • Cardiacin primarily is eliminated by the kidneys; therefore, the dose of Cardiacin should be reduced in patients with kidney dysfunction.
  • Cardiacin blood levels are used for adjusting doses in order to avoid toxicity.
  • The usual starting dose is 0.0625-0.25 mg daily depending on age and kidney function.
  • The dose may be increased every two weeks to achieve the desired response.
  • The usual maintenance dose is 0.125 to 0.5 mg per day.

What is Cardiacin?

Cardiacin is derived from the leaves of a digitalis plant. Cardiacin helps make the heart beat stronger and with a more regular rhythm.

Cardiacin is used to treat heart failure.

Cardiacin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the heart).

Neuromuscular blocker

Taking Cardiacin with succinylcholine can lead to an irregular heart rhythm.

HIV medications

Taking Cardiacin with certain HIV drugs can increase the level of Cardiacin in your body. This could cause increased side effects. If you need to take these drugs with Cardiacin, your doctor may lower your dose of Cardiacin before you start taking these medications.

Examples of these drugs include:

  • ritonavir
  • saquinavir
  • lopinavir/ritonavir


Pharmacologic class: Cardiac glycoside

Therapeutic class: Inotropic, antiarrhythmic

Pregnancy risk category C

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