Bosoptin tablets


  • Active Ingredient: Verapamil
  • 240 mg, 120 mg, 80 mg
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What is Bosoptin?

The active ingredient of Bosoptin brand is verapamil. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy α-(1-methylethyl) hydrochloride Verapamil hydrochloride, USP is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Verapamil hydrochloride is not chemically related to other cardioactive drugs. Inactive ingredients include calcium sulfate, colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate, talc and titanium dioxide.

Used for

Bosoptin is used to treat diseases such as: Angina, Arrhythmia, Bipolar Disorder, Cluster Headaches, High Blood Pressure, Idiopathic Hypertrophic Subaortic Stenosis, Migraine Prevention, Nocturnal Leg Cramps, Supraventricular Tachycardia.

Side Effect

Possible side effects of Bosoptin include: swollen joints; sweating; lightheadedness, dizziness, or fainting; swelling in legs and ankles; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; confusion; cold sweats; Difficulty having a bowel movement (stool).

How to Buy Bosoptin tablets online?

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ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?

El Bosoptino se usa para tratar la presiГіn arterial alta y controlar la angina (dolor en el pecho). Las tabletas de liberaciГіn inmediata tambiГ©n se usan solas o con otros medicamentos para prevenir y tratar los latidos cardГ­acos irregulares. El Bosoptino pertenece a una clase de medicamentos llamados bloqueadores de los canales de calcio. ActГєa relajando los vasos sanguГ­neos, de modo que el corazГіn no tenga que bombear con tanta fuerza. TambiГ©n aumenta el flujo sanguГ­neo y la oxigenaciГіn del corazГіn, y disminuye la actividad elГ©ctrica del corazГіn para controlar la frecuencia cardГ­aca.

La hipertensiГіn arterial es una condiciГіn comГєn y cuando no se trata, puede causar daГ±os en el cerebro, el corazГіn, los vasos sanguГ­neos, los riГ±ones y otras partes del cuerpo. El daГ±o a estos Гіrganos puede causar enfermedades del corazГіn, un infarto, insuficiencia cardГ­aca, apoplejГ­a, insuficiencia renal, pГ©rdida de la visiГіn y otros problemas. AdemГЎs de tomar medicamentos, hacer cambios de estilo de vida tambiГ©n le ayudarГЎ a controlar su presiГіn arterial. Estos cambios incluyen comer una dieta que sea baja en grasa y sal, mantener un peso saludable, hacer ejercicio al menos 30 minutos casi todos los dГ­as, no fumar y consumir alcohol con moderaciГіn.

Bosoptin–Rivaroxaban Pharmacokinetic Modelling and Bleed Risk Potential

Bosoptin may increase bleed risk with rivaroxaban, and this risk may be augmented in renal impairment. Twenty-seven volunteers (mean age 59 years) were split into two renal function cohorts: normal and mild insufficiency (mean CrCl 71 mL/min). Participants received two doses of rivaroxaban 20 mg, one on day 1 and one on day 15. Study subjects also received single morning doses of oral extended-release Bosoptin 120 mg on day 8, 240 mg on day 9, and 360 mg on days 10–17. Rivaroxaban Cmax did not differ between the normal and mild insufficiency groups, with or without Bosoptin. However, within each group, Bosoptin significantly increased rivaroxaban AUC (by 39% and 42%, respectively), reduced CrCl (by 28% and 32%, respectively), and prolonged T1/2 (by 18% and 43%, respectively). Bosoptin also enhanced rivaroxaban antithrombotic effects .

Another study of 27 subjects evaluated a pharmacokinetic (PK) model system with Bosoptin and rivaroxaban in various renal function categories (CrCl 80–130 mL/min, CrCl 50–79 mL/min, CrCl 30–49 mL/min, and CrCl 15–29 mL/min). Addition of Bosoptin 360 mg daily to rivaroxaban 20 mg daily increased steady-state rivaroxaban AUC by 48%, 49%, 50%, and 51%, respectively. Reducing rivaroxaban to 15 mg daily increased AUC to a lesser extent (11%, 12%, 12%, and 13%, respectively). On the other hand, rivaroxaban 10 mg daily reduced AUC by 26%, 26%, 25%, and 25%, respectively. These models predicted an increased major bleeding risk when combining Bosoptin 360 mg daily and rivaroxaban 20 mg daily, suggesting that, when given with Bosoptin 360 mg daily, rivaroxaban be reduced to 15 mg daily in normal renal function and mild renal impairment, or 10 mg daily in moderate to severe renal impairment .

Geriatric Use

The pharmacokinetics of COVERA-HS were studied after 5 consecutive nights of dosing 180 mg in 30 healthy young (19–43 years) versus 30 healthy elderly (65–80 years) male and female subjects. Older subjects had significantly higher mean Bosoptin Cmax, Cmin, and AUC(0–24h) compared to younger subjects. Older subjects had mean AUCs that were approximately 1.7–2.0 times higher than those of younger subjects as well as a longer average Bosoptin t½ (approximately 20 hr vs. 13 hr). These results were typical of the age-related differences seen with many drug products in clinical medicine. Lean body mass was inversely related to AUC, but no gender difference was observed in the clinical trials of COVERA-HS. However, there are conflicting data in the literature suggesting that Bosoptin clearance may decrease with age in women to a greater degree than in men. Mean Tmax was similar in young and elderly subjects.

Alcohol Interaction

Bosoptin may increase the amount of alcohol in your blood and make alcohol effects continue longer. Alcohol may also make the effects of Bosoptin stronger. This can cause your blood pressure to be too low.

Bosoptin Warnings

This medicine controls high blood pressure, arrhythmia, and angina, but it does not cure these conditions. You should continue to take Bosoptin even if you feel well.

Before taking Bosoptin, tell your doctor if you have or have ever had:

  • Any condition that causes food to move through your digestive system more slowly
  • Myasthenia gravis (a condition that causes certain muscles to weaken)
  • Heart failure
  • Heart, liver, or kidney disease
  • Muscular dystrophy (an inherited disease that causes weakening of the muscles).

You should also tell your doctor you are taking Bosoptin before any type of surgery, including dental procedures.

Your doctor will likely start you on a low dose of Bosoptin and then gradually increase your dose.

You should keep all appointments with your doctor while taking this medicine. You will need your blood pressure checked regularly to determine how you are responding to Bosoptin.

If you take a certain version of the extended-release tablets, you might notice an empty tablet shell in your stool. This does not mean that you did not receive your complete dose of medication.

Q: I'm taking Bosoptin. Is it okay to eat or drink grapefruit/grapefruit juice?

A: Many medications interact with grapefruit and hence its consumption is discouraged when taking medications. Studies suggest that grapefruit's effects on Bosoptin is contradictory and unpredictable. Patient's liver function and kidney function also affects this interaction. Therefore, to be completely safe, it is best to avoid grapefruit juice completely.

Possible side effects of Bosoptin

The most common side effects experienced by patients taking Bosoptin include:

Rarely, Bosoptin may cause serious side effects, such as congestive heart failure or pulmonary edema.

Michael Stewart, Reviewed by Sid Dajani | Last edited 31 Jan 2018 | Certified by The Information Standard

You can take Bosoptin either before or after meals.

Do not drink grapefruit juice whilst you are on Bosoptin.

The most common side-effect of treatment is constipation.

Common Side Effects of Bosoptin

You should tell your doctor if any of the following side effects are severe or do not go away:

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