Arrest

Arrest

  • Active Ingredient: Albendazole
  • 400 mg
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What is Arrest?

The active ingredient of Arrest brand is albendazole. Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Used for

Arrest is used to treat diseases such as: Ascariasis, Capillariasis, Cutaneous Larva Migrans, Cysticercus cellulosae, Echinococcus, Enterocolitis, Filariasis, Elephantiasis, Giardiasis, Gnathostomiasis, Hookworm Infection (Necator or Ancylostoma), Hydatid Disease, Liver Fluke, Loiasis, Microsporidiosis, Neurocysticercosis, Pinworm Infection (Enterobius vermicularis), Strongyloidiasis, Trichinosis, Trichostrongylosis, Visceral Larva Migrans, Toxicariasis, Whipworm Infection.

Side Effect

Possible side effects of Arrest include: Black, tarry stools; stomach pain, continuing; unusual tiredness or weakness; blurred vision; headache; sores, ulcers, or white spots on the lips or in the mouth; sore throat; unusual bleeding or bruising.

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7.4 Theophylline

Following a single dose of Arrest (400 mg), the pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged. Arrest induces cytochrome P450 1A in human hepatoma cells; therefore, it is recommended that plasma concentrations of theophylline be monitored during and after treatment.

Theophylline

Following a single dose of Arrest (400 mg), the pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged. Arrest induces cytochrome P450 1A in human hepatoma cells; therefore, it is recommended that plasma concentrations of theophylline be monitored during and after treatment.

Pediatrics

Studies in children younger than 6 years are limited, but several studies have shown Arrest to be safe in children as young as 1 year of age. For children 1–2 years old, a dose of 200 mg is recommended. Use of Arrest in children

Contraindications

  • Hypersensitivity to Arrest or benzimidazoles.

Effects of Drug Abuse

  • See "What Are Side Effects Associated with Using Arrest?"

  • See "What Are Side Effects Associated with Using Arrest?"

  • Monitor theophylline levels if used concomitantly.
  • Potential for bone marrow suppression, aplastic anemia and agranulocytosis; monitor blood counts in all patients at the beginning of each 28-day cycle of therapy, and every 2 weeks while on therapy; discontinue therapy if clinically significant changes in blood counts occur.
  • Pre-existing neurocysticercosis may be uncovered in patients treated with Arrest for other conditions, apparent by neurological symptoms (such as seizures, increased intracranial pressure, focal signs); promptly treat with corticosteroid and anticonvulsant therapy.
  • Obtain pregnancy test in women of reproductive potential prior to therapy and avoid usage in pregnant women except in clinical circumstances where no alternative management is appropriate; discontinue therapy if pregnancy occurs and apprise patient of potential hazard to fetus.
  • Risk of retinal damage in retinal cysticercosis; cases of retinal involvement reported; examine patient for presence of retinal lesions before initiating therapy for neurocysticercosis.
  • Reversible elevations of liver enzymes may occur; monitor liver enzymes before start of each treatment cycle and at least every 2 weeks while on therapy and discontinue if clinically significant elevations occur; patients with abnormal liver function tests and hepaticechinococcosis are at increased risk of hepatotoxicity; discontinue therapy if liver function test elevations are greater than 2 times upper limit of normal; may consider restarting treatment when liver function test values return to pretreatment levels.

  • Use Arrest during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Breastfeeding patients should use caution while using Arrest; consult your physician.

Arrest side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

fever, chills, sore throat, mouth sores, feeling light-headed;

increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects may include:

headache, neck stiffness, increased sensitivity to light, confusion;

nausea, vomiting, stomach pain;

dizziness, spinning sensation; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Adverse reactions and s > Leukopenia and thrombocytopenia are possible in dogs and cats. Arrest has an affinity for rapidly dividing cells and may cause toxicity to bone marrow and intestinal epithelium. High doses have been associated with bone marrow toxicity ( J Am Vet Med Assoc, 213: 44-46, 1998) in dogs and cats, and it should be used cautiously in small animals. In other species, at approved doses, there is a wide margin of safety. Adverse effects can include anorexia, lethargy, and bone marrow toxicity.

How to use Arrest

Take this medication by mouth with meals as directed by your doctor, usually 1 to 2 times daily. If you or your child have trouble swallowing tablets, you may crush or chew your dose and take it with water.

For some conditions (such as hydatid disease), your doctor may direct you to take this medication in a treatment cycle (for example, twice daily with meals for 28 days then stopping the medication for 2 weeks). Carefully follow your doctor's instructions.

The dosage is based on your weight, medical condition, and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. If your doctor directs you to take this medication in a treatment cycle, it may be helpful to mark the calendar with a reminder of when you need to restart the medication.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Other medications (such as corticosteroids, anti-seizure medications) may also be prescribed for your current condition. Take those medications exactly as directed by your doctor.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Tell your doctor if your condition lasts or gets worse.

Pharmacokinetics

Bioavailability of Arrest is poor, but is increased when ingested with food. Absorption can be increased five-fold when Arrest is ingested with high-fat foods. Arrest is rapidly converted to Arrest sulfoxide via first pass hepatic metabolism, reaching peak levels 2–5 hours after ingestion. Arrest sulfoxide is 70% protein bound in plasma and is distributed throughout tissue, including cerebrospinal fluid. Concentrations in hydatid cyst fluid are higher than those seen for mebendazole. The mean half-life is 8–12 hours, with excretion probably through the biliary system. Conversion to Arrest sulfoxide also occurs in the gut epithelium, where the metabolite is then excreted directly into the lumen. There is significant intra- and inter-individual variability.


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