Areplex tablets

Areplex

  • Active Ingredient: Clopidogrel
  • 75 mg
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What is Areplex?

The active ingredient of Areplex brand is clopidogrel. Clopidogrel helps to prevent platelets in your blood from sticking together and forming a blood clot. Unwanted blood clots can occur with certain heart or blood vessel conditions. Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole. Effect of Clopidogrel on other drugs In vitro studies have shown that the glucuronide metabolite of Clopidogrel is a strong inhibitor of CYP2C8. Concomitant administration of repaglinide with Clopidogrel increased the systemic exposure to repaglinide (AUC0-∞) by 5.1-fold following the loading dose (300 mg) and by 3.9-fold on day 3 of the maintenance dose (75 mg) of Clopidogrel [see Drug Interactions (7.5)].

Used for

Areplex is used to treat diseases such as: Acute Coronary Syndrome, Acute Coronary Syndrome, Prophylaxis, Heart Attack, Ischemic Stroke, Ischemic Stroke, Prophylaxis, Percutaneous Coronary Intervention, Peripheral Arterial Disease, Platelet Aggregation Inhibition, Transient Ischemic Attack.

Side Effect

Possible side effects of Areplex include: Nosebleed; blurred vision; blood in the urine or stools; bloating; inflammation of the joints; pains in the stomach, side, or abdomen, possibly radiating to the back; nausea or vomiting; swollen or painful glands.

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What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Signs of low blood sugar like dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating.
  • A severe blood problem called thrombotic thrombocytopenic purpura (TTP) has happened with Areplex. Sometimes, this has been deadly. Call your doctor right away if you feel confused, very tired, or very weak, or if you have weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or change in eyesight. Call your doctor right away if you have a fast heartbeat; fever; headache; pale skin; less urine passed or urine that is pink or has blood in it; purple spots on the skin or mouth; seizures; severe diarrhea, stomach pain, upset stomach, or throwing up; shortness of breath; or yellow skin or eyes.

Generic Name: Areplex (kloe PID oh grel)Brand Name: Plavix

Medically reviewed by Drugs.com on Oct 22, 2018 – Written by Cerner Multum

Areplex side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Areplex increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.

Also call your doctor at once if you have:

pale skin, easy bruising, purple spots under your skin or in your mouth;

jaundice (yellowing of your skin or eyes);

fast heartbeats, shortness of breath;

headache, fever, weakness, feeling tired;

little or no urination;

signs of a blood clot--sudden numbness or weakness, confusion, problems with vision or speech.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Things to consider

If you have certain health conditions such as a peptic ulcer or bleeding disorder you should not take Areplex, unless advised by a specialist.

You should use Areplex with caution if you have liver or kidney problems.

Areplex must not be given to anyone under 16 years old, unless under specialist advice. It's also not recommended if you're pregnant or breastfeeding.

Algunos efectos secundarios pueden ser graves. Si experimenta alguno de los sГ­ntomas siguientes, llame a su mГ©dico inmediatamente:

  • urticaria
  • salpullido
  • picazГіn
  • dificultad para respirar o tragar
  • inflamaciГіn del rostro, garganta, lengua, labios, ojos, manos, pies, tobillos o parte inferior de las piernas
  • ronquera
  • heces negras y alquitranadas
  • sangre roja en las heces
  • vГіmito con sangre
  • vГіmito que se ve como cafГ© molido
  • moretones o sangrado inusuales
  • orina rosada o marrГіn
  • dificultad para hablar o hablar lento
  • debilidad u hormigueo de un brazo o una pierna
  • cambios en la visiГіn
  • fiebre
  • dificultad para respirar
  • ritmo cardiaco rГЎpido
  • piel pГЎlida
  • parches morados o sangrado debajo de la piel
  • confusiГіn
  • amarilleamiento de la piel o los ojos
  • convulsiones

El Areplex puede ocasionar otros efectos secundarios. Llame a su mГ©dico si tiene algГєn problema inusual mientras toma este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgaciГіn de efectos adversos 'MedWatch' de la AdministraciГіn de Alimentos y Medicamentos (FDA, por su sigla en inglГ©s) en la pГЎgina de Internet (http://www.fda.gov/Safety/MedWatch) o por telГ©fono al 1-800-332-1088.

Introduction

Areplex (brand name Plavix) is an antiplatelet medicine. This means it reduces the risk of blood clots forming.

Normally, when there is a cut or break in a small blood vessel, a blood clot forms to plug the hole until the blood vessel heals.

Small cells in the blood called platelets cause the blood to clot. When a platelet detects a damaged area of a blood vessel, it produces a chemical that attracts other platelets and makes them stick together to form a blood clot.

Areplex reduces the ability of the platelets to stick together and reduces the risk of clots forming. This protects you from having a stroke or heart attack.

Q: Should you continue to take Plavix after one year?

A: Only your physician can determine how long you need to be on your prescribed medication based on the reason it was prescribed and your underlying health status. Plavix (Areplex) can be taken with or without food. Because Areplex keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop. If you need to have any type of surgery or dental work, tell the surgeon or dentist ahead of time that you are using Areplex. You may need to stop using the medicine for at least five days before having surgery, to prevent excessive bleeding. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor. Store Areplex at room temperature away from moisture and heat. Lowell Sterler, RPh

Other uses for this medicine

Areplex is also sometimes used to prevent blood clots in people with atrial fibrillation (a condition in which the heart beats irregularly). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Laurie Barclay, MD

January 22, 2004

Jan. 22, 2004 -- For high-risk patients who have had a myocardial infarction (MI) or stroke, Areplex is significantly better than aspirin in preventing recurrent cardiovascular events, according to an analysis of data from the Areplex Versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial published in the February issue of Stroke.

"Just because a patient came in with a heart attack today doesn't mean he or she is only at risk for a future heart attack," coauthor Deepak L. Bhatt, MD, from the Cleveland Clinic Foundation in Ohio, says in a news release. "The next time, it may be a stroke or other arterial problem."

In the CAPRIE trial, patients with a history of MI or stroke were randomized to receive either Areplex or aspirin after a cardiovascular event (CVE). Overall, risk of recurrent CVE was 8.7% lower in those who received Areplex than in those who received aspirin.

In a subgroup of 4,496 high-risk patients followed after a second CVE, the Areplex group had a 14.9% lower relative risk of recurrent CVE than the aspirin group. Risk of a subsequent CVE was higher in patients who had already had two CVEs, even if the second or third event was not necessarily the same as the first.

"The third event may be fatal," Dr. Bhatt said. "If a patient has a history of multiple , they are better off being treated with Areplex rather than aspirin."

After one- and three-year follow-ups, patients receiving Areplex were less likely than those receiving aspirin to have been hospitalized for or to have died from a CVE.

One year after their second event, 16.1% of the Areplex group and 18.5% of the aspirin group had had an ischemic stroke, MI, or repeat hospitalization for CVE. The composite end point of ischemic stroke, MI, or vascular death was reached in 8.8% of the Areplex-treated patients and in 10.2% of the aspirin-treated patients.

After three years, 32.7% of the Areplex group and 36.6% of the aspirin group had had another CVE, and vascular death had occurred in 20.4% of the Areplex group and in 23.8% of the aspirin group. Based on these findings, treating 29 very high-risk patients with Areplex would prevent one vascular death, MI, or ischemic stroke over three years.

Study limitations include post-hoc analysis and lack of power to detect differences in cerebrovascular, coronary, and peripheral arterial events as predictors of further CVEs.

"The absolute benefit of Areplex over aspirin seems to be amplified in high-risk patients, whereas the relative benefit is similar across end points related to vascular ischemia," the authors write.

Reviewed by Gary D. Vogin, MD

Medscape Medical News © 2004

Cite this: Laurie Barclay. Areplex Better than Aspirin for High-Risk Patients - Medscape - Jan 22, 2004.

ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?

El Areplex se usa solo o con aspirina para prevenir problemas graves o potencialmente mortales del corazГіn y los vasos sanguГ­neos en personas que han tenido un derrame cerebral, infarto dolor de pecho muy fuerte. Esto incluye personas que tienen una intervenciГіn coronaria percutГЎnea (ICP; angioplastia; un tipo de cirugГ­a del corazГіn) que pueda involucrar la inserciГіn de una endoprГіtesis coronaria (stent); tubo metГЎlico que se coloca quirГєrgicamente en los vasos sanguГ­neos para mejorar el flujo de la sangre) o quienes tienen un injerto de baipГЎs en una arteria coronaria (un tipo de cirugГ­a del corazГіn). El Areplex tambiГ©n se usa para prevenir problemas graves o potencialmente mortales del corazГіn y los vasos sanguГ­neos en personas que tienen una enfermedad arterial perifГ©rica (mala circulaciГіn en los vasos sanguГ­neos que suministran sangre a las piernas). El Areplex pertenece a una clase de medicamentos llamados agentes antiplaquetarios. Funciona al prevenir que las plaquetas (un tipo de glГіbulo sanguГ­neo) se amontone y forme coГЎgulos que pueden causar un infarto o un derrame cerebral.

Q: Does Plavix cause dizziness?

A: According to the prescribing information, dizziness was not a reported side effects associated with Plavix (Areplex) treatment. Plavix (Areplex) inhibits the platelets in the blood from clotting and is used to prevent blood clots that can occur after a heart attack, stroke and in patients with certain heart and blood vessel disorders. According to the prescribing information, the most commonly reported side effect associated with Plavix treatment was bleeding. If you experience any signs and symptoms of bleeding, including nosebleeds or other bleeding that will not stop, coughing up blood or vomit that looks like coffee grounds or black, bloody or tarry stools, it is important to contact your healthcare provider immediately. Plavix should be taken with a full glass of water and can be taken without regard to food. If you need dental work or surgery, it is extremely important to inform your doctor that you take Plavix. You may need to stop taking Plavix for at least 5 days prior to surgery or a procedure to avoid bleeding excessively. This should only be done under the supervision of your doctor. You should begin taking Plavix as soon as possible and exactly as directed by your doctor. Beth Isaac, PharmD

Which drugs or supplements interact with Areplex?

Combining Areplex with warfarin (Coumadin) or other drugs that cause bleeding increases the risk of bleeding.

Areplex is converted to its active form by enzymes in the liver. Drugs that reduce the activity of these enzymes, for example, omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium) may reduce the activity of Areplex and should not be used with Areplex. Other drugs that also may react with Areplex in a similar fashion include fluoxetine (Prozac, Sarafem), cimetidine (Tagamet), fluconazole (Diflucan), ketoconazole (Nizoral, Extina, Xolegel, Kuric), voriconazole (Vfend), ethaverine (Ethatab, Ethavex), felbamate (Felbatol), and fluvoxamine (Luvox).

What is Areplex, and how does it work (mechanism of action)?

Areplex bisulfate (Plavix) is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Areplex prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other drugs in this class include ticagrelor (Brilinta) and prasugrel (Effient). Areplex is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Unlike ticlopidine, Areplex bisulfate does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack, and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking.) Areplex bisulfate is used to reduce the risk of heart attacks and strokes in these patients. Areplex bisulfate was approved by the FDA in 1997.

How to use Areplex

Read the Medication Guide provided by your pharmacist before you start taking Areplex and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication to prevent clots after a stent implant or other procedure, take this medication with aspirin for many months to years after the procedure (depending on the procedure/type of stent) as directed by your doctor. Consult your doctor for more details and about the risks of stopping early. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Get medical help right away if you have any signs that this medication is not working, such as symptoms of a new heart attack or stroke (such as chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, slurred speech, sudden vision changes, confusion).

Warnings for other groups

For pregnant women: Studies done in pregnant women taking Areplex have not shown an increased risk of birth defects or miscarriage. Studies of Areplex in pregnant animals also have not shown these risks.

However, there are potential risks to the mother and fetus if a heart attack or stroke occurs during pregnancy. Therefore, the benefit of Areplex in preventing these health events may outweigh any risk of the drug on the pregnancy.

Tell your doctor if you’re pregnant or plan to become pregnant. Areplex should be used during pregnancy only if the potential benefit justifies the potential risk.

For women who are breastfeeding: It isn’t known if Areplex passes into breastmilk. If it does, it may cause serious effects in a child who is breastfed. You and your doctor may need to decide if you’ll take Areplex or breastfeed.

For children: The safety and effectiveness of Areplex hasn’t been established in children younger than 18 years.

Areplex oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.

If you have to temporarily stop taking Areplex, start taking it again as soon as your doctor tells you to. Stopping this drug may increase your risk of serious heart conditions, stroke, or a blood clot in the legs or lungs.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include bleeding.

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take Areplex as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Take only one dose at your regular time. Don’t take two doses of Areplex at the same time unless your doctor tells you to.

How to tell if the drug is working: You should not have a heart attack or stroke.

Keep these considerations in mind if your doctor prescribes Areplex oral tablet for you.

Q: Is Plavix supposed to smell like vinegar?

A: Plavix (Areplex) is used to reduce the risk of stroke or heart attack in patients who have already had a heart attack or stroke or in patients who have other heart and circulatory problems. There is no information about Plavix smelling like vinegar. For other drugs, like aspirin, a strong vinegar-like smell can indicate that the drug is breaking down and should not be used. Please contact your local pharmacist to examine the medication and determine the appropriate course of action. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

What might happen:

When Areplex is taken with grapefruit juice, the grapefruit juice may prevent your body from activating Areplex and it may not work as well.

clop >
  • What is Areplex, and how does it work (mechanism of action)?
  • What are the uses for Areplex?
  • What are the side effects of Areplex?
  • What is the dosage for Areplex?
  • Which drugs or supplements interact with Areplex?
  • Is Areplex safe to take if I'm pregnant or breastfeeding?
  • What else should I know about this drug?

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Areplex. For a full list, see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.


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