Aldex

Aldex

  • Active Ingredient: Albendazole
  • 400 mg
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What is Aldex?

The active ingredient of Aldex brand is albendazole. Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Used for

Aldex is used to treat diseases such as: Ascariasis, Capillariasis, Cutaneous Larva Migrans, Cysticercus cellulosae, Echinococcus, Enterocolitis, Filariasis, Elephantiasis, Giardiasis, Gnathostomiasis, Hookworm Infection (Necator or Ancylostoma), Hydatid Disease, Liver Fluke, Loiasis, Microsporidiosis, Neurocysticercosis, Pinworm Infection (Enterobius vermicularis), Strongyloidiasis, Trichinosis, Trichostrongylosis, Visceral Larva Migrans, Toxicariasis, Whipworm Infection.

Side Effect

Possible side effects of Aldex include: diarrhea; cough; Dizziness; painful or difficult urination; bleeding gums; Nausea; sores, ulcers, or white spots on the lips or in the mouth; Blistering, peeling, loosening of the skin.

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About Aldex 400 MG Tablet

Aldex is an antiparasitic medication which treats diseases caused by an infestation of parasitic worms. It is generally taken for diseases like neurocysticercosis (affecting the brain, muscles and other tissues), giardiasis (intestinal infection), hydatid disease, pinworm disease (intestinal infection), ascariasis (gastrointestinal infection), filariasis (affecting the lymph nodes and vessels) and others. The medicine falls under the group of drugs known as anthelmintics, which expels the parasitic worms either by stunning them or killing them without causing notable damage to the host body. It is available in the form of tablets and taken.

Before you start this medication, you must inform your doctor if you have any of the following health conditions:

  • Blockage in the biliary tract
  • Liver disease
  • A low blood count (low platelet, white cell or red cell count)
  • If you are pregnant or planning to get pregnant
  • If you are a breast-feeding mother
  • In case you are allergic to Aldex 400 MG Tablet, or any other medicines or food

In case you forget to take a dose of this medication, you can take it as soon as you remember it. Do not take two doses together just because you missed one. It should also be kept in mind not to stop your medicines before the prescribed time, even if you think you are feeling better. Apart from that, you must consult your child’s paediatrician before using this tablet to treat your child’s condition.

Aldex

Aldex is a benzimidazole carbamate that has a broad spectrum of anthelmintic activity, including against Ascaris lumbricoides, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Echinococcus spp. and T. solium cysticerci. 1,2,64–67 The drug has also been used to treat eosinophilic enterocolitis caused by Ancylostoma caninum, Capillaria philippinensis, cutaneous and visceral larva migrans, C. sinensis, Gnathostoma spinigerum, Oesophagostomum bifurcum and Trichostrongylus spp. It is also used in combination with diethylcarbamazine or ivermectin for mass treatment of lymphatic filariasis (Brugia malayi and Wuchereria bancrofti). 68 Additionally, it has variable efficacy in the treatment of microsporidiosis caused by Encephalitozoon hellem, E. cuniculi, E. intestinalis, E. bieneusi and Vittaforma corneae. 69 Aldex has some activity against G. lamblia. 38

The mechanism of action is similar to that of mebendazole with blockade of parasite microtubule assembly. Aldex is poorly soluble in water and should be taken with a fatty meal to enhance absorption.

Single doses of Aldex are generally well tolerated; abdominal discomfort, diarrhea or migration of Ascaris into the mouth and nose occur infrequently. Prolonged, high-dose treatment can be associated with reversible aminotransferase elevations, bone marrow suppression and alopecia.

12.4 Microbiology

Mechanism of Action

ALBENZA binds to the colchicine-sensitive site of β-tubulin inhibiting their polymerization into microtubules. The decrease in microtubules in the intestinal cells of the parasites decreases their absorptive function, especially the uptake of glucose by the adult and larval forms of the parasites, and also depletes glycogen storage. Insufficient glucose results in insufficient energy for the production of adenosine trisphosphate (ATP) and the parasite eventually dies.

Mechanism of Resistance

Parasitic resistance to Aldex is caused by changes in amino acids that result in changes in the β-tubulin protein. This causes reduced binding of the drug to β-tubulin.

In the specified treatment indications Aldex appears to be active against the larval forms of the following organisms:

What Other Drugs Interact with Aldex?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Aldex has no known severe interactions with other drugs.

Aldex has no known serious interactions with other drugs.

Moderate interactions of Aldex include:

Minor interactions of Aldex include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

How should I take Aldex?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

In a young child (or anyone who is unable to swallow a whole Aldex tablet), the tablet should be crushed or chewed and swallowed with a full glass of water.

You may be given other medicines to prevent certain side effects of Aldex, or certain effects that can result when the parasites die within your body.

Tell your doctor if you have any changes in weight. Aldex doses are based on weight.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Aldex will not treat a viral infection such as the flu or a common cold.

Aldex can weaken your immune system. Your blood may need to be tested often. You will need frequent blood tests (every 2 weeks) to check your liver function.

Store at room temperature away from moisture and heat.

Drug-Interaction

The investigators of a recent trial evaluated the effectiveness of combined therapy of praziquantel and Aldex (50 mg/kg/day and 15 mg/kg/day, respectively) in comparison to two different doses of just Aldex (15 or 22.5 mg/kg/day) in the treatment of neurocysticercosis . Praziquantel is also an anthelmintic that works by causing strong contractions within the parasite that causes paralysis and eventual dislodgment . The purpose of the study was to determine if combining the two different mechanisms would be more effective than single agent therapy. It has also been noted in the past that praziquantel increases the serum concentration of the active metabolite of Aldex . The side effects listed by the study were described as seizures, headache, pregnancy, drug-induced hepatitis, and “other” which included spontaneous abortion, urinary tract infection, motor vehicle accident, dizziness, fever, vomiting, and intracranial hypertension. While all of the side effect groups except for the drug-induced hepatitis were more common in the increased dose of Aldex or the combination therapy than in the standard Aldex therapy, the study found that the increased prevalence of adverse effects was not statistically significant. Currently, there is not a listed interaction between Aldex and praziquantel with the active ingredients of birth control.

COMMON BRAND(S): Albenza

GENERIC NAME(S): Aldex

OTHER NAME(S): Aldex Tablet

This medication is used to treat certain tapeworm infections (such as neurocysticercosis and hydatid disease).

Dosage Forms And Strengths

  • Tablet: 200 mg

Each white to off-white, circular, biconvex, bevel-edged film coated, TILTAB tablet is debossed with “ap” and “550” and contains 200 mg of Aldex.

Bottles of 2 Tablets NDC 52054-550-22 Bottles of 28 Tablets NDC 52054-550-28

What other drugs will affect Aldex?

Other drugs may interact with Aldex, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

ALBENZA (Aldex) is an orally administered anthelmintic drug. Chemically, it is methyl 5-(propylthio)-2-benzim >12 H 15 N 3 O 2 S. Its molecular weight is 265.34. It has the following chemical structure:

Aldex disease interactions

There are 4 disease interactions with Aldex which include:

What are the uses for Aldex?

Aldex is FDA approved for the treatment of the following parasitic infections:

  • Hydatid Disease Aldex is used for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by dog tapeworm (Echinococcus granulosus) larvae.
  • Neurocysticercosis Aldex is used to treat parenchymal neurocysticercosis due to active lesion caused by pork tapeworm (Taenia solium) larvae.
  • Off-label use Aldex is also effective in treating infections caused by other parasites including Taenia saginata (beef tapeworm), Trichinella spiralis (pork worm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Strongyloides stercoralis (threadworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm).

What Is Aldex and How Does It Work?

Aldex is a prescription drug used to treat certain tapeworm infections (such as neurocysticercosis and hydatid disease).

Aldex is available under the following different brand names: Albenza.

Dosages of Aldex:

Adult and Pediatric Dosages:

Dosage Considerations – Should be Given as Follows:

Neurocysticercosis (Taenia solium Tapeworm)

Adult and Pediatric

  • Over 60 kg: 400 mg orally twice daily for 8-30 days
  • Under 60 kg: 15 mg/kg/day divided twice daily orally for 8-30 days; not to exceed 800 mg/day

Hydatid (Echinococcus Tapeworm)

Adult and Pediatric:

  • Over 60 kg: 400 mg orally twice daily for 28 days, then 14 drug-free days for 3 cycles
  • Under 60 kg: 15 mg/kg/day divided twice daily orally, no more than 800 mg/day for 28 days than 14 drug-free days for 3 cycles

Adult and Pediatric:

Adult and Pediatric:

  • 400 mg orally once daily for 10 days

Adult and Pediatric:

  • 400 mg orally once daily for 3 days

Adult and Pediatric:

  • 400 mg orally once daily for 5 days

Adult and Pediatric:

Fluke (Clonorchis sinesis)

  • 10 mg/kg orally once daily for 7 days

  • 400 mg twice daily for 21 days

  • Take with food
  • If unable to swallow, may crush tablet and drink with water
  • Monitor: complete blood count (CBC), liver function tests


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