Albentel

Albentel

  • Active Ingredient: Albendazole
  • 400 mg
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What is Albentel?

The active ingredient of Albentel brand is albendazole. Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Used for

Albentel is used to treat diseases such as: Ascariasis, Capillariasis, Cutaneous Larva Migrans, Cysticercus cellulosae, Echinococcus, Enterocolitis, Filariasis, Elephantiasis, Giardiasis, Gnathostomiasis, Hookworm Infection (Necator or Ancylostoma), Hydatid Disease, Liver Fluke, Loiasis, Microsporidiosis, Neurocysticercosis, Pinworm Infection (Enterobius vermicularis), Strongyloidiasis, Trichinosis, Trichostrongylosis, Visceral Larva Migrans, Toxicariasis, Whipworm Infection.

Side Effect

Possible side effects of Albentel include: cough; Black, tarry stools; Fever; joint or muscle pain; shortness of breath.

How to Buy Albentel online?

To buy Albentel online - just click on the "Buy Now" button from the top and follow along with our shop. Order and payment takes a couple of minutes, and all steps are evident. We don't take a medical prescription and we have many methods of payment. With each detail of rapid delivery and confidentiality, you can read on the applicable pages on the hyperlinks from the navigation menu.

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Theophylline

Following a single dose of Albentel (400 mg), the pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged. Albentel induces cytochrome P450 1A in human hepatoma cells; therefore, it is recommended that plasma concentrations of theophylline be monitored during and after treatment.

12.3 Pharmacokinetics

Albentel is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Albentel concentrations are negligible or undetectable in plasma as it is rapidly converted to the sulfoxide metabolite prior to reaching the systemic circulation. The systemic anthelmintic activity has been attributed to the primary metabolite, Albentel sulfoxide. Oral bioavailability appears to be enhanced when Albentel is coadministered with a fatty meal (estimated fat content 40 grams) as evidenced by higher (up to 5-fold on average) plasma concentrations of Albentel sulfoxide as compared to the fasted state.

Maximal plasma concentrations of Albentel sulfoxide were achieved 2 hours to 5 hours after dosing and were on average 1310 ng/mL (range 460 ng/mL to 1580 ng/mL) following oral doses of Albentel (400 mg) in 6 hydatid disease patients, when administered with a fatty meal. Plasma concentrations of Albentel sulfoxide increased in a dose-proportional manner over the therapeutic dose range following ingestion of a high-fat meal (fat content 43.1 grams). The mean apparent terminal elimination half-life of Albentel sulfoxide ranged from 8 hours to 12 hours in 25 healthy subjects, as well as in 14 hydatid and 8 neurocysticercosis patients.

Following 4 weeks of treatment with Albentel (200 mg three times daily), 12 patients’ plasma concentrations of Albentel sulfoxide were approximately 20% lower than those observed during the first half of the treatment period, suggesting that Albentel may induce its own metabolism.

Albentel sulfoxide is 70% bound to plasma protein and is widely distributed throughout the body; it has been detected in urine, bile, liver, cyst wall, cyst fluid, and cerebrospinal fluid (CSF). Concentrations in plasma were 3-fold to 10-fold and 2-fold to 4-fold higher than those simultaneously determined in cyst fluid and CSF, respectively.

Metabolism and Excretion

Albentel is rapidly converted in the liver to the primary metabolite, Albentel sulfoxide, which is further metabolized to Albentel sulfone and other primary oxidative metabolites that have been identified in human urine. Following oral administration, Albentel has not been detected in human urine. Urinary excretion of Albentel sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of Albentel sulfoxide similar to those achieved in plasma.

Following single-dose administration of 200 mg to 300 mg (approximately 10 mg/kg) ALBENZA to 3 fasted and 2 fed pediatric patients with hydatid cyst disease (age range 6 to 13 years), Albentel sulfoxide pharmacokinetics were similar to those observed in fed adults.

Although no studies have investigated the effect of age on Albentel sulfoxide pharmacokinetics, data in 26 hydatid cyst patients (up to 79 years) suggest pharmacokinetics similar to those in young healthy subjects.

Albentel

Albentel is a synthetic nitroimidazole with a broad spectrum of antinematodal activity similar to that of mebendazole but also with anticestodal and some antiprotozoal action. The advantage of Albentel over mebendazole is its activity in a single oral dose of 400 mg (200 mg for children 73,74 It has good activity in multiple doses against both cutaneous larva migrans and strongyloidiasis, but single-dose therapy with ivermectin is more effective for these two helminthic infections. 75,76 Successful treatment of visceral larva migrans has been reported. 77 Efficacy against the microfilarial stage of Wuchereria bancrofti, Brugia malayi, and Loa loa is well documented, although DEC remains the drug of choice for treatment of individual patients with these filarial infections. 78–80 DEC and Albentel in combination has superior activity against adult W. bancrofti compared with either drug alone. 81 Reports with limited numbers of patients have documented the activity of Albentel in giardiasis, 82 microsporidiosis, 83 clonorchiasis, trichinellosis, and capillariasis, but its role in treatment of these infections has yet to be defined. The benefit of any existing chemotherapy for gnathostomiasis or angiostrongyliasis is doubtful, but Albentel is thought to be the most active benzimidazole. 84

Prolonged high-dose regimens of Albentel constitute the most effective medical treatment of larval cestode disease caused by Echinococcus granulosus, E. multilocularis, and E. vogelii. 85 Some studies suggest that an initial trial of medical therapy can obviate surgical intervention in relatively uncomplicated disease. 86 Dosage is not defined in children 87–90 In comparative nonblinded trials, Albentel appeared to have slightly higher activity than praziquantel. Cerebrospinal fluid levels of Albentel are approximately 40% plasma levels. Either 8 or 28 days of therapy has been used, with cycles repeated according to clinical judgment. Corticosteroids, which increase plasma levels of Albentel up to 50%, usually are administered concomitantly. Albentel has activity in multiple doses against adult Taenia spp., but its use is discouraged for this indication.

The mode of action of Albentel is identical to that already described for mebendazole. Intake with a fatty meal is necessary to attain tissue levels required to treat extraluminal helminths. Detectable levels are achieved in serum, cerebrospinal fluid, cyst fluid, and bile with a serum half-life of 8 to 15 hours depending on the dose. Rapid extensive hepatic biotransformation to the active metabolite, Albentel sulfoxide, occurs, but the major route of excretion is not clear. Side effects of low-dose Albentel therapy are minimal, consisting of diarrhea, abdominal pain, migration of Ascaris through the mouth or nose, and rare hypersensitivity. With high-dose therapy, elevations of hepatic transaminases, dizziness, neutropenia, and alopecia are most common. 91 Serum hepatic enzyme levels and blood count should be monitored every 2 weeks during high-dose therapy. No problems specific to children have been documented and considerations in using Albentel

Treatment

Albentel has been proven to be efficacious for gnathostomiasis, with cure rates of over 90% at a dose of 400 mg bd for 21 days. Small studies of ivermectin 200 µg/kg either as a stat dose or on two consecutive days seem to show similar efficacy to Albentel. Initial treatment is not always successful and second courses of treatment have been needed in some cases. Either Albentel or ivermectin may be used sequentially in such patients. Further trials are needed to determine whether relapse rates are lower with combination drugs than with monotherapy. Follow-up should be for at least 1 year. 19,20

Adverse reactions and s > Leukopenia and thrombocytopenia are possible in dogs and cats. Albentel has an affinity for rapidly dividing cells and may cause toxicity to bone marrow and intestinal epithelium. High doses have been associated with bone marrow toxicity ( J Am Vet Med Assoc, 213: 44-46, 1998) in dogs and cats, and it should be used cautiously in small animals. In other species, at approved doses, there is a wide margin of safety. Adverse effects can include anorexia, lethargy, and bone marrow toxicity.

Dosage Forms And Strengths

  • Tablet: 200 mg

Each white to off-white, circular, biconvex, bevel-edged film coated, TILTAB tablet is debossed with “ap” and “550” and contains 200 mg of Albentel.

Bottles of 2 Tablets NDC 52054-550-22 Bottles of 28 Tablets NDC 52054-550-28

These highlights do not include all the information needed to use ALBENZA ® safely and effectively. See full prescribing information for ALBENZA.

ALBENZA ® (Albentel) tablets, for oral use Initial U.S. Approval: 1996

Albentel 200 Mg Tablet Price With Coupon (Cost Comparison)

It may need to be taken as soon as or twice a day, relying on the degree of problem and kind of infection managed. You could be certain we provide you the very best spots to get Albentel online, so comprising your mind will take just a couple of minutes of your time. Our special comparison page is there to assist you make a decision, as we checked hundreds of drug stores with ideal reviews by real consumers like on your own. Albentel could be taken as a solitary dosage or in courses of 2 weeks long.

This would certainly imply having the ability to purchase Albentel on the internet safely and in just a few mins. It's always great to have a dependable drug store at your solution. Our special comparison web page is there to help you choose, as we inspected hundreds of drug stores with best assessments by real clients like yourself. The results of this medicine are based upon preventing the worms in the physical body from being able to multiply and possibly affect the organs. Albentel could be taken as a solitary amount or in courses of 2 weeks long.

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Albentel.

Albentel is a synthetic nitroimidazole with a broad spectrum of antinematodal activity similar to that of mebendazole but with anticestodal and some antiprotozoal action. Mebendazole is no longer manufactured in the United States, and its use has been supplanted by Albentel. The advantage of Albentel over mebendazole is its activity in a single oral dose of 400 mg (200 mg for children 68,69

Because intestinal helminthiasis typically is multiparasitic, Albentel is an almost ideal agent. 70,71 It has good activity in multiple doses against cutaneous larva migrans and strongyloidiasis, but single-dose therapy with ivermectin is more effective for these two helminthic infections. 72,73 Successful treatment with Albentel of visceral larva migrans has been reported, although ivermectin is the drug of choice. 74 Efficacy against the microfilarial stage of Wuchereria bancrofti, Brugia malayi, and Loa loa is well documented, although diethylcarbamazine (DEC) remains the parasite adulticidal drug of choice for the treatment of patients with these filarial infections. 75–77 DEC plus Albentel in combination has superior activity against adult W. bancrofti compared with either drug alone. 78 Albentel may be of benefit in patients with gnathostomiasis, baylisascariasis, trichinellosis, toxociariasis, capillariasis, and angiostrongyliasis.

Prolonged high-dose regimens of Albentel constitute the most effective medical treatment of larval cestode disease caused by Echinococcus granulosus, E. multilocularis, and E. vogelii. 79 Dosage is not defined for children younger than 6 years of age. Treatment is tailored to response and normally is required for a minimum of several weeks or months. Albentel should be started several days before surgery to minimize the effect of intraoperative spillage of cyst contents. Albentel also is used in the treatment of patients with cysticercosis, often with concomitant steroids. 80–82

Albentel binds irreversibly to the nematodal isoform of β-tubulin, blocking microtubule assembly, disrupting tegumental integrity, inhibiting motility, and impeding glucose uptake by the worm. Detectable levels are achieved in serum, cerebrospinal fluid, cyst fluid, and bile, with a serum half-life of 8 to 15 hours depending on the dose. Rapid, extensive hepatic biotransformation to the active metabolite, Albentel sulfoxide, occurs, but the major route of excretion is not clear.

Side effects of low-dose Albentel therapy are minimal, consisting of diarrhea, abdominal pain, migration of Ascaris through the mouth or nose, and rare hypersensitivity. With high-dose or prolonged therapy, elevated levels of hepatic transaminases, dizziness, neutropenia, and alopecia are most common. 83 Serum hepatic enzyme levels and the blood count should be monitored every 2 weeks during high-dose therapy.

Lack of data for children younger than 2 years of age has precluded specific US labeling for or establishment of dosage for this age group, although the label leaves the physician discretion in electing to treat children younger than 2 years of age. The pediatric dosage is identical to the adult dosage. Embryotoxic potential usually precludes the use of Albentel during pregnancy.

Albentel is manufactured as a suspension and as tablets that can be crushed with food, chewed, or taken whole. Albentel is poorly absorbed and should be ingested with food, preferably a fatty meal, to maximize absorption.

What should I avoid while taking Albentel?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

How should I take Albentel?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

If you cannot swallow the tablet whole, you may crush or chew it and swallow with a full glass of water.

You may be given other medicines to prevent certain side effects of Albentel, or certain effects that can result when the parasites die within your body.

Albentel doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.

Use Albentel for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Albentel will not treat a viral infection such as the flu or a common cold.

Albentel can increase your risk of bleeding or infection. You will need frequent medical tests.

Your liver function may also need to be checked every 2 weeks.

Store at room temperature away from moisture and heat.

How should I take Albentel?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

In a young child (or anyone who is unable to swallow a whole Albentel tablet), the tablet should be crushed or chewed and swallowed with a full glass of water.

You may be given other medicines to prevent certain side effects of Albentel, or certain effects that can result when the parasites die within your body.

Tell your doctor if you have any changes in weight. Albentel doses are based on weight.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Albentel will not treat a viral infection such as the flu or a common cold.

Albentel can weaken your immune system. Your blood may need to be tested often. You will need frequent blood tests (every 2 weeks) to check your liver function.

Store at room temperature away from moisture and heat.


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