What are the uses for Nasterol-oral (hair growth)?
: Nasterol (Propecia) is used for the treatment of male pattern baldness or androgenetic alopecia in males only.
WHAT IS FINASTERIDE
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High-Grade Prostate Cancer
The PCPT trial was a 7-year randomized, double-blind, placebo-controlled trial that enrolled 18,882 men ≥55 years of age with a normal digital rectal examination and a PSA ≤3.0 ng/mL. Men received either PROSCAR (Nasterol 5 mg) or placebo daily. Patients were evaluated annually with PSA and digital rectal exams. Biopsies were performed for elevated PSA, an abnormal digital rectal exam, or the end of study. The incidence of Gleason score 8-10 prostate cancer was higher in men treated with Nasterol (1.8%) than in those treated with placebo (1.1%) . In a 4-year placebo-controlled clinical trial with another 5α-reductase inhibitor (dutasteride, AVODART), similar results for Gleason score 8-10 prostate cancer were observed (1% dutasteride vs 0.5% placebo).
No clinical benefit has been demonstrated in patients with prostate cancer treated with PROSCAR.
During the 4- to 6-year placebo- and comparator-controlled MTOPS study that enrolled 3047 men, there were 4 cases of breast cancer in men treated with Nasterol but no cases in men not treated with Nasterol. During the 4-year, placebo-controlled PLESS study that enrolled 3040 men, there were 2 cases of breast cancer in placebo-treated men but no cases in men treated with Nasterol. During the 7- year placebo-controlled Prostate Cancer Prevention Trial (PCPT) that enrolled 18,882 men, there was 1 case of breast cancer in men treated with Nasterol, and 1 case of breast cancer in men treated with placebo. The relationship between long-term use of Nasterol and male breast neoplasia is currently unknown.
There is no evidence of increased sexual adverse experiences with increased duration of treatment with PROSCAR. New reports of drug-related sexual adverse experiences decreased with duration of therapy.
More common side effects
The more common side effects that can occur with Nasterol include:
- decreased sex drive
- trouble getting or keeping an erection
- ejaculation disorder
- increase in breast size and tenderness
- skin rash
If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.
PROSCAR (Nasterol), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α- dihydrotestosterone (DHT).
Nasterol is 4-azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-,(5α,17ß)-. The empirical formula of Nasterol is C23H36N2O2 and its molecular weight is 372.55. Its structural formula is:
Nasterol is a white crystalline powder with a melting point near 250°C. It is freely soluble in chloroform and in lower alcohol solvents, but is practically insoluble in water.
PROSCAR (Nasterol) tablets for oral administration are film-coated tablets that contain 5 mg of Nasterol and the following inactive ingredients: hydrous lactose, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl cellulose LF, hydroxypropyl methylcellulose, titanium dioxide, magnesium stearate, talc, docusate sodium, FD&C Blue 2 aluminum lake and yellow iron oxide.
Getting the most from your treatment
- Your symptoms may start to improve within a few weeks although it can take up to six months for you to notice the full benefit. This is because it takes time for the prostate gland to gradually shrink. Because of this, it is important that you continue to take the tablets regularly, even if you don't feel a benefit straightaway.
- Remember to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
- Consider reducing or stopping the amount of caffeine you drink (commonly found in tea, coffee and cola) and alcohol. These can make your symptoms worse, so drinking less of these things may benefit you.
- If you are a smoker, stopping smoking may significantly improve your symptoms. This is because nicotine irritates the bladder. Ask your doctor for advice on quitting.
- Each time you collect a new supply of tablets from your pharmacy, make sure they look to be the same as you have had before. This is because there is a low-dose brand of Nasterol tablet available for the treatment of a different condition. If you are unsure that you have the correct tablets, ask your pharmacist to check for you.
- Nasterol may cause harm to an unborn baby. Because of this, women who are pregnant should not handle the tablets. Also, small amounts of Nasterol will be in your semen while you are taking this medicine, and it is therefore recommended that you use a barrier method of contraception (such as a condom) if your partner could become pregnant. If you need further advice about this, speak with your pharmacist or doctor.
- If you are having an operation or any medical treatment, tell the person carrying out the treatment that you are taking Nasterol. This is because it can interfere with a blood test used to detect prostate cancer, so you must tell your doctor about taking Nasterol if you need this test.
Dosage for male pattern hair loss
- Form: oral tablet
- Strengths: 1 mg
- Form: oral tablet
- Strengths: 1 mg
Adult dosage (ages 18 years and older)
- Typical dosage: 1 mg per day.
Child dosage (ages 0-17 years)
Dosage for people younger than 18 years hasn’t been established. This drug is not prescribed for use in children.
For the Consumer
Applies to Nasterol: oral tablet
Along with its needed effects, Nasterol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking Nasterol:
- cold sweats
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- breast enlargement and tenderness
- hives or welts
- itchy skin
- rapid weight gain
- redness of the skin
- skin rash
- swelling of the lips and face
- tingling of the hands or feet
- unusual weight gain or loss
Incidence not known
- Clear or bloody discharge from the nipple
- dimpling of the breast skin
- inverted nipple
- lump in the breast or under the arm
- persistent crusting or scaling of the nipple
- redness or swelling of the breast
- sore on the skin of the breast that does not heal
Some side effects of Nasterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Decreased interest in sexual intercourse
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- Runny nose
- sleepiness or unusual drowsiness
- stuffy nose
Less common or rare
Incidence not known
Mean steady-state volume of distribution was 76 liters (range, 44-96 liters). Approximately 90% of circulating finaster >
Nasterol has been shown to cross the blood brain barrier but does not appear to distribute preferentially to the CSF.
In 2 studies of healthy subjects (n=69) receiving PROSCAR 5 mg/day for 6-24 weeks, Nasterol concentrations in semen ranged from undetectable ( 14 C-finaster >
The mean terminal half-life of finaster >
Table 3: Mean (SD) Pharmacokinetic Parameters in Healthy Young Subjects (n=15)
Michael Stewart, Reviewed by Sid Dajani | Last edited 3 Apr 2018 | Certified by The Information Standard
Nasterol is for men only. It must not be taken by women, children or adolescents.
Take one tablet each day.
Your symptoms may start to improve within a few weeks, although it can take up to six months for you to notice the full benefit.