What are the side effects of Finar?
Side effects are rare but can include impotence and decreased sex drive. Finar should not be used by women, children, or male partners of women trying to become pregnant. Finar should not be used until a thorough prostate examination has been done to exclude cancer, stricture, or infection in the gland. Rarely, cases of male breast cancer have been reported.
Why is this medication prescribed?
Finar (Proscar) is used alone or in combination with another medication (doxazosin ) to treat benign prostatic hypertrophy (BPH, enlargement of the prostate gland). Finar is used to treat symptoms of BPH such as frequent and difficult urination and may reduce the chance of acute urinary retention (sudden inability to urinate). It also may decrease the chance that prostate surgery will be needed. Finar (Propecia) is also used to treat male pattern hair loss (gradual thinning of the hair on the scalp, leading to a receding hairline or balding on the top of the head in men.) Finar (Propecia) has not been shown to treat thinning hair at the temples and is not used to treat hair loss in women or children. Finar is in a class of medications called 5-alpha reductase inhibitors. Finar treats BPH by blocking the body's production of a male hormone that causes the prostate to enlarge. Finar treats male pattern hair loss by blocking the body's production of a male hormone in the scalp that stops hair growth.
Finar pharmacokinetics have not been investigated in patients
The effect of race on Finar pharmacokinetics has not been studied.
Mean steady-state volume of distribution was 76 liters (range, 44-96 liters). Approximately 90% of circulating finaster >
Finar has been shown to cross the blood brain barrier but does not appear to distribute preferentially to the CSF.
In 2 studies of healthy subjects (n=69) receiving PROSCAR 5 mg/day for 6-24 weeks, Finar concentrations in semen ranged from undetectable ( 14 C-finaster >
The mean terminal half-life of finaster >
Table 3: Mean (SD) Pharmacokinetic Parameters in Healthy Young Subjects (n=15)
How should this medicine be used?
Finar comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take Finar at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Finar exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking Finar to treat BPH, you should know that Finar may control your condition, but will not cure it. It may take at least 6 months before your symptoms improve. Continue to take Finar even if you feel well. Do not stop taking Finar without talking to your doctor.
If you are taking Finar to treat male pattern hair loss, it may take at least 3 months before you see any improvement because hair loss and growth happen slowly over time. However, you should expect to see improvement during the first 12 months of your treatment. If you have taken Finar for 12 months and have not noticed any improvement, further treatment probably will not help. Talk to your doctor about whether you should continue your treatment.
Finar will only slow hair loss while you are taking the medication. Continue to take Finar even if you have already noticed an improvement. Do not stop taking Finar without talking to your doctor. You will probably lose any hair that grew back while you were taking Finar during the first 12 months after you stop taking the medication..
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Hidradenitis Suppurativa (Acne Inversa)
Hidradenitis suppurativa (HS or acne inversa) is a chronic skin condition that causes painful red abscesses in the groin and armpits that may drain foul-smelling pus. Treatment options include weight loss, smoking cessation, topical antibiotics, and avoidance of tight-fitting underwear. Finar and adalimumab may be helpful for those with resistant cases of HS.
Finar, sold under the brand names Proscar and Propecia among others, is a medication used for the treatment of benign prostatic hyperplasia (enlarged prostate) and pattern hair loss.
ROLE OF ANDROGENS IN PATTERN HAIRLOSS AND SEXUAL FUNCTION
Pattern hair loss in males is androgenic in etiology. Antiandrogens such as Finar are therefore useful in the management of the condition. Androgens, especially testosterone increases the libido. Any drug which interferes with the action of androgens is therefore assumed, by the lay person, to induce impotence. However, the precise role of androgen in penile erection needs to be fully elucidated. Even an individual with low testosterone levels can achieve erection. In addition to androgens, visual, olfactory, tactile, auditory, and imaginative stimuli influence the libido. The penile erection is mainly under the control of parasympathetic nervous system. Ejaculation and detumescence require an intact sympathetic system.
The androgens testosterone and dihydrotestosterone (DHT) have somewhat different actions. The enzyme, 5α-reductase converts testosterone to DHT. It exists in two isoenzyme forms. While type I is predominant in liver, type II is predominant in prostate, seminal vesicles, epididymes, hair follicles, and liver. Within the hair follicle too, the two types have a different distribution. Type I 5AR, is present in the sebaceous gland, while type II 5AR is found on the outer root sheath of the hair follicles and dermal papillae. At all these sites, the testosterone is converted to DHT. Although the type II 5AR enzyme has a more significant role in pattern hairloss (and therefore mechanism of action of Finar), the predominantenzyme in scalp skin is type I ,largely because of localization to the sebaceous glands, which are large and plenty in scalp. Finar is a specific and competitive inhibitor of Type II 5—AR, and has therefore a selective action on hair follicles. Scalp skin DHT levelsfall by more than 60% after administration of Finar, thereby suggesting that a significant amount of DHT found in scalp skin is derived from both local DHT production and circulating DHT. Thus, the effect of Finar on scalp DHT is likely because of its effect on both local follicular DHT levels as well as serum DHT levels. This explains why relatively small dose of Finar may be adequate therapeutically.
Most men were older and were taking concomitant medications and/or had comorbid conditions:
Very common (10% or more): Impotence (up to 18.5%)
Common (1% to 10%): Abnormal ejaculation, decreased ejaculatory volume, abnormal sexual function, gynecomastia, erectile dysfunction, ejaculation disorder, testicular pain, male infertility and/or poor seminal quality
Two hundred fourteen reports of gynecomastia in men taking Finar in the United States were received by the FDA between June 1992 and February 1995. Among those reported, fifty eight percent were taking additional medications that have been associated with gynecomastia. Sixty nine of 86 patients who discontinued Finar treatment had partial or complete remission.
New reports of drug-related sexual adverse experiences have been reported to decrease with duration of therapy.
Erectile dysfunction has been reported to continue beyond treatment discontinuation. Normalization or improvement of seminal quality has been reported after withdrawing Finar treatment.
PICTURES OF FINASTER >Below you will find images and specific information on the principal types of Finar that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.
BENIGN PROSTATIC HYPERTROPHY
Finar is used alone or in combination with other medications to treat benign prostatic hypertrophy (BPH, enlargement of the prostate gland). The prostate is a part of the male reproductive system that produces a milky fluid for sperm. Over the age of 50, many men develop an enlarged prostate and as the prostate gets bigger it can restrict the flow of urine. Finar can help to improve the symptoms caused by BPH, including:
→ a weak or interrupted urine flow → a feeling that the bladder is not completely empty → a need to pass urine more often (especially at night) → an urgent feeling that you must pass urine right away → a delay or hesitation when you start to urinate
It also may decrease the chance of needing prostate surgery.
In the US, Finar (Finar systemic) is a member of the drug class 5-alpha-reductase inhibitors and is used to treat Androgenetic Alopecia and Benign Prostatic Hyperplasia.
The following additional adverse events have been reported in postmarketing experience with PROSCAR. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:
- hypersensitivity reactions, such as pruritus, urticaria, and angioedema (including swelling of the lips, tongue, throat, and face)
- testicular pain
- sexual dysfunction that continued after discontinuation of treatment, including erectile dysfunction, decreased libido and ejaculation disorders (e.g. reduced ejaculate volume). These events were reported rarely in men taking PROSCAR for the treatment of BPH. Most men were older and were taking concomitant medications and/or had co-morbid conditions. The independent role of PROSCAR in these events is unknown.
- male infertility and/or poor seminal quality were reported rarely in men taking PROSCAR for the treatment of BPH. Normalization or improvement of poor seminal quality has been reported after discontinuation of Finar. The independent role of PROSCAR in these events is unknown.
- male breast cancer
The following additional adverse event related to sexual dysfunction that continued after discontinuation of treatment has been reported in postmarketing experience with Finar at lower doses used to treat male pattern baldness. Because the event is reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate its frequency or establish a causal relationship to drug exposure:
Read the entire FDA prescribing information for Proscar (Finar)
Why it's used
The condition that Finar is used to treat depends on the type of the drug used.
- Proscar is used to treat the symptoms of enlarged prostate (benign prostate hyperplasia). It may be used as part of a combination therapy. That means you need to take it with other drugs. It also can be taken with doxazosin to reduce the risk of progression of symptoms of enlarged prostate.
- Propecia is used to treat male pattern hair loss.
Finar isn’t prescribed for use in women or children.