• Active Ingredient: Esomeprazole
  • 40 mg, 20 mg
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What is Zomel?

The active ingredient of Zomel brand is esomeprazole. Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Used for

Zomel is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer Prophylaxis, Erosive Esophagitis, Gastric Ulcer Prophylaxis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, NSAID-Induced Gastric Ulcer, Pathological Hypersecretory Conditions, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Zomel include: Acne; back pain; vomiting; skin rash, hives, itching; seizures; yellow eyes or skin; seeing, hearing, or feeling things that are not there.

How to Buy Zomel online?

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Some studies indicate that the differences between omeprazole and Zomel may offer some advantages to people with certain conditions.

An older study from 2002 found that Zomel provided more effective control of GERD than omeprazole at the same doses.

According to a later study in 2009, Zomel offered faster relief than omeprazole in the first week of use. After one week, symptom relief was similar.

However, in a 2007 article in American Family Physician, doctors questioned these and other studies on PPIs. They cited concerns such as:

  • differences in the amount of active ingredients given in the studies
  • the size of the studies
  • the clinical methods used to measure effectiveness

The authors analyzed 41 studies on the effectiveness of PPIs. They concluded that there’s little difference in the effectiveness of PPIs.

So, while there’s some data to suggest that Zomel is more effective at relieving symptoms, most experts agree that the PPIs have similar effects overall.

The American College of Gastroenterology states that there are no major differences in how well different PPIs work for treating GERD.

Do I need a prescription for Zomel?

  • Yes - Nexium, Nexium IV
  • No - Nexium 24 hour

Q: Sometimes after I eat I feel that I have an irregular heartbeat or feel bloated. I was put on Nexium which doesn't seem to help. Is this the right medication?

A: Your health care provider is best able to guide your treatment decisions based on your specific circumstances. Consult your health care provider for proper evaluation and diagnosis of your symptoms and for concerns about the effectiveness of Nexium for your condition. Nexium (Zomel) decreases the amount of acid produced in the stomach. It is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Nexium is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). And it may also be given to prevent gastric ulcers caused by infection with helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs). You may also find helpful information at: //www.everydayhealth.com/drugs/nexium Sarah Lewis, PharmD

Q: Is there a generic for Nexium 40mg?

A: Nexium (Zomel) is in a drug class called proton pump inhibitors. Nexium is used to treat gastroesophageal reflux disease (GERD). Nexium is also used to prevent ulcers (sores in the lining of the stomach) in people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). In combination with certain other medications, Nexium is used to treat and prevent the recurrence of stomach ulcers caused by H. pylori, a type of bacteria. Nexium is also used to treat conditions (e.g., Zollinger-Ellison Syndrome) in which the stomach makes too much acid. Nexium works be reducing acid production in the stomach. Generic drugs are lower-cost alternatives to more expensive brand-name drugs. They will appear different and have a few other minor differences from the brand-name drugs, but their labeling and directions for use must be virtually the same as that of the brand name product. Both brand-name and generic drug manufacturing facilities must follow the same standards of good manufacturing practices and meet the U.S. Food and Drug Administration's (FDA) specifications. The FDA also requires that generic drugs be bioequivalent to their brand-name counterparts. This means that a generic drug will work the same way in your body as the brand-name medication. Generics are considered by the FDA to be identical to brand-name drugs in dose, strength, route of administration, safety, efficacy, and intended use. Currently there is not a generic version of Nexium available. The price of a medication, like Nexium, can vary depending on the wholesaler and pharmacy from which the medication is acquired. Pharmacies sell medication to consumers at a price that includes the cost for acquiring the drug from the wholesaler, plus a retail markup. If a third-party payer (for example, a health insurance company or Medicare) is providing coverage for a medication, such as Nexium, they determine the final cost of the product. Costs will vary from one plan to another, and the payer may cover or reimburse part or all of the cost. In addition to Nexium, Aciphex (rabeprazole), Kapidex (dexlansoprazole), Nexium (Zomel), Prevacid (lansoprazole), Prilosec (omeprazole), and Protonix (pantoprazole) belong to the proton pump inhibitor drug class. Studies show that, in general, proton pump inhibitors are about equally effective. Moreover, in general, there is little scientific evidence that there are any important differences in the safety of the proton pump inhibitors. As such, many third-party payers promote

What other drugs will affect Zomel?

Tell your doctor about all your current medicines. Many drugs can affect Zomel, especially:

Important Information

Zomel can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Zomel may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking Zomel long term or more than once per day.

Risk Reduction Of Rebleeding Of Gastric Or Duodenal Ulcers Following Therapeutic Endoscopy In Adults

Adult dose is 80 mg administered as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg/h for a total treatment duration of 72 hours (i.e., includes initial 30-minute dose plus 71.5 hours of continuous infusion). Intravenous therapy is aimed solely at the acute initial management of bleeding gastric or duodenal ulcers and does not constitute full treatment. Intravenous therapy should be followed by oral acid-suppressive therapy. For patients with liver impairment, no dosage adjustment of the initial Zomel 80 mg infusion is necessary. For patients with mild to moderate liver impairment (Child-Pugh Classes A and B), a maximum continuous infusion of Zomel 6 mg/h should not be exceeded. For patients with severe liver impairment (Child-Pugh Class C), a maximum continuous infusion of 4 mg/h should not be exceeded .


  • This medication contains Zomel. Do not take Nexium, or Nexium 24HR if you are allergic to Zomel or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of NEXIUM. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing Reports - There have been spontaneous reports of adverse events with postmarketing use of Zomel. These reports occurred rarely and are listed below by body system:

Blood And Lymphatic System Disorders: agranulocytosis, pancytopenia; Eye Disorders: blurred vision; Gastrointestinal Disorders: pancreatitis; stomatitis; microscopic colitis; fundic gland polyps; Hepatobiliary Disorders: hepatic failure, hepatitis with or without jaundice; Immune System Disorders: anaphylactic reaction/shock; systemic lupus erythematosus; Infections and Infestations: GI candidiasis; Metabolism and nutritional disorders: hypomagnesemia with or without hypocalcemia and/or hypokalemia; Musculoskeletal And Connective Tissue Disorders: muscular weakness, myalgia, bone fracture; Nervous System Disorders: hepatic encephalopathy, taste disturbance; Psychiatric Disorders: aggression, agitation, depression, hallucination; Renal and Urinary Disorders: interstitial nephritis; Reproductive System and Breast Disorders: gynecomastia; Respiratory, Thoracic and Mediastinal Disorders: bronchospasm; Skin and Subcutaneous Tissue Disorders: alopecia, erythema multiforme, hyperhidrosis, photosensitivity, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN, some fatal), cutaneous lupus erythematosus.

Other adverse events not observed with NEXIUM, but occurring with omeprazole can be found in the omeprazole package insert, ADVERSE REACTIONS section.

  • K >Magnesium vs. strontium vs. sodiumThere are three types of Zomel: Zomel magnesium, Zomel strontium, and Zomel sodium. (This article is about Zomel magnesium.) They’re all Zomel, but they contain different salt forms. The different salt forms enable Zomel to be used to treat gastrointestinal issues in a range of people with different health needs.

Zomel is a prescription drug. Some forms are also available over the counter, but this article covers the prescription version only.

Zomel magnesium and Zomel strontium come as delayed-release capsules. Zomel magnesium also comes as a liquid suspension. Zomel sodium comes in an intravenous (IV) form, which is only given by a healthcare provider.

Zomel magnesium is available as the brand-name drug Nexium and as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Zomel magnesium may be used as part of a combination therapy. This means you may need to take it with other medications, especially to treat H. pylori.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Zomel.

Q: I have acid reflux and hiatus hernia. Should I be taking Nexium, even though I am not bothered with problems?

A: The decision on whether or not you need to be on a medication should be made by your health care provider. There are many variables in this decision. If you are currently taking Nexium (Zomel) (//www.everydayhealth.com/drugs/nexium) you may not be having symptoms because the medication is working for you. As always, talk with your health care provider regarding questions you have about your medication. The following link will take you to information provided by Everyday Health regarding acid reflux or GERD: //www.everydayhealth.com/gerd/guide/. Jen Marsico, RPh

Where can I get more information?

Your pharmacist can provide more information about Zomel.

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