What Are the Typical Dosages for Taclar?
Taclar comes as a tablet, an extended-release tablet, and a liquid form. The regular tablets and liquid forms are typically taken every 12 hours for seven to 14 days. The extended-release tablets are usually taken every 24 hours for seven to 14 days. You should begin to feel better after the first few days of treatment.
For most infections, the recommended adult dose of Taclar is 250-500 milligrams (mg) of immediate release tablets twice daily, or 1,000 mg of extended- release tablets once daily for seven to 14 days.
This medication may be taken with or without food. You should take the tablets with a full glass of water and swallow the extended-release tablets whole. Shake the liquid well before each use to mix it evenly, and do not refrigerate after mixing.
Concomitant administration of BIAXIN with cisapride and pimozide is contraindicated .
There have been postmarketing reports of drug interactions when Taclar is co-administered with cisapride or pimozide, resulting in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) most likely due to inhibition of metabolism of these drugs by BIAXIN. Fatalities have been reported.
- Chlamydophila pneumoniae
- Helicobacter pylori
- Mycobacterium avium complex (MAC) consisting of M. avium and M. intracellulare
- Mycoplasma pneumoniae
At least 90 percent of the microorganisms listed below exhibit in vitro minimum inhibitory concentrations (MICs) less than or equal to the Taclar susceptible MIC breakpoint for organisms of similar type to those shown in Table 11. However, the efficacy of Taclar in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials.
Why it's used
Taclar is used to prevent and treat certain infections caused by bacteria.
Taclar may be used with other drugs (ethambutol, rifampin, amoxicillin, lansoprazole, omeprazole, or bismuth) to treat stomach ulcers or mycobacterial infections.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Many drugs besides Taclar may affect the heart rhythm (QT prolongation), including amiodarone, disopyramide, dofetilide, pimozide, procainamide, quinidine, sotalol, among others.
Other medications can affect the removal of Taclar from your body, which may affect how Taclar works. Examples include rifamycins (such as rifabutin), efavirenz, nevirapine, saquinavir, among others.
Taclar can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include colchicine, digoxin, some drugs used to treat erectile dysfunction-ED/pulmonary hypertension (such as sildenafil, tadalafil), ergot alkaloids (such as ergotamine, dihydroergotamine), some statin drugs (such as lovastatin, simvastatin), tamsulosin, tolvaptan, ticagrelor, among others.
Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.
Case 1. Cholestatic hepatitis after Taclar.
Gastroenterol Clin Biol 1997; 21: 632-3. French. PubMed Citation]
A 74 year old man with acute bronchitis was treated with a 10 day course of Taclar (500 mg daily) and developed nausea and jaundice by day 7. Because of itching and worsening symptoms, he sought medical advice and was hospitalized. He was jaundiced and had right upper quadrant tenderness over the liver, but was not febrile. He denied a history of alcohol intake and had no risk factors for viral hepatitis. Laboratory tests showed marked elevations in alkaline phosphatase and bilirubin levels with moderate increases in ALT and AST levels. He tested negative for markers of hepatitis A, B and C, had low levels of antinuclear and anti-smooth muscle antibody, and liver ultrasound was normal. A liver biopsy showed intrahepatic cholestasis with centrolobular ballooning degeneration, portal inflammation with a prominence of eosinophils, and ductular proliferation. His other medications that he took chronically were stopped at the same time. He recovered over the next few weeks and all liver tests were normal in follow up 3 months later.
Taclar has been shown to be active against most of the isolates of the following microorganisms both in vitro and in clinical infections .
Mechanism Of Action
Taclar is a macrolide antimicrobial drug .
Which drugs or supplements interact with Taclar?
Taclar interacts with several drugs because it reduces the activity of liver enzymes that breakdown many drugs. This leads to increased blood levels and side effects from the affected drugs. Examples of such interactions include
Taclar increases blood levels of sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), vardenafil (Levitra), theophylline and carbamazepine (Tegretol), thereby increasing side effects of these drugs.
Ritonavir (Norvir) and atazanavir (Reyataz) increase blood levels of Taclar while efavirenz (Sustiva), nevirapine (Viramune), rifampin, decrease blood levels of Taclar.
Itraconazole (Sporanox) and saquinavir (Invirase) may increase blood levels of Taclar while Taclar increases blood levels or both drugs.
The occurrence of abnormal heart beats may increase when Taclar is combined with drugs that affect heart beat (for example, amiodarone , quinidine , and disopyramide).
Taclar (Biaxin, Biaxin XL) is an antibiotic drug prescribed for the treatment of a large variety of bacterium. Taclar is used to treat infections of the middle ear, tonsils, throat, larynx, bronchioles, lungs, and skin. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
Taclar is prescribed to treat bacterial infections such as respiratory infections, ear infections and skin infections. It can be taken by adults and children. It works by stopping the bacteria causing the infection from multiplying.
Rated Taclar for Tonsillitis/Pharyngitis Report
I have a throat, sinus & ear infection all at once. My first med taken was zpack which helped but didn’t make the infection fully go away because I stopped taking the med once I was feeling better which cause the infection to come back but this time it was resistant to the antibiotics. Next, I tried Amoxicillin and it helped but didn’t fully take away the infection. After that I was prescribed Augmentin, which did nothing. Finally, I went to an ENT and was prescribed Taclar and steroids to get rid of the infection and dry, swollen soft palate. After 2 days of taking this med I was so excited because it seems like it is working the best but now on day 3, I am having terrible anxiety, heart palpitations, feels like my heart keeps stopping & short episodes of blacking out. I can not finish taking this drug because of it’s terrifying side effects. It’s a shame because my swelling is almost gone and throat and ear pain has decreased major.
Rated Taclar for Bronchitis- acute Report
Started with 500mg twice daily. After 2days got aches and pains in neck shoulders back and legs. Freezing cold for hours. Stopped taking it for 24 hours then started again,all side effects returned so fatigued i couldn't move. Shall never take this drug again i thought i was dying.
- CrCl 30-60 mL/min: No dosage adjustment necessary
- CrCl 30-60 mL/min and concomitant atazanavir or ritonavir-containing regimens: Decrease Taclar dose by 50%
Helicobacter Pylori Infection And Duodenal Ulcer Disease
BIAXIN Filmtab is given in combination with other drugs in adults as described below to eradicate H. pylori. The eradication of H. pylori has been demonstrated to reduce the risk of duodenal ulcer recurrence .
- BIAXIN Filmtab in combination with amoxicillin and PREVACID (lansoprazole) or PRILOSEC (omeprazole) Delayed-Release Capsules, as triple therapy, are indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or five-year history of duodenal ulcer) to eradicate H. pylori.
- BIAXIN Filmtab in combination with PRILOSEC (omeprazole) capsules are indicated for the treatment of patients with an active duodenal ulcer associated with H. pylori infection. Regimens which contain BIAXIN Filmtab as the single antibacterial agent are more likely to be associated with the development of Taclar resistance among patients who fail therapy. Taclar-containing regimens should not be used in patients with known or suspected Taclar resistant isolates because the efficacy of treatment is reduced in this setting.