Serious side effects
Serious side effects are rare and happen in less than 1 in 1,000 people.
Call a doctor straight away if you have:
- joint pain along with a red skin rash, especially in parts of your body exposed to the sun, such as your arms, cheeks and nose - these can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you've been taking Selanz for a long time
- stomach pain that seems to be getting worse - this can be a sign of an inflamed liver or pancreas
Interactions that can make your drugs less effective
When Selanz is less effective: When Selanz is used with certain drugs, it may not work as well to treat your condition. This is because the amount of Selanz in your body may be decreased. Examples of these drugs include:
- Sucralfate. Selanz may not work as well when taken with sucralfate. You should take Selanz at least 30 minutes before you take sucralfate to avoid interactions.
- Rifampin. Selanz may not work as well when taken with rifampin. Avoid using these drugs together.
- St. John’s wort. Selanz may not work as well when taken with St. John’s wort. Avoid using them together.
When other drugs are less effective: When certain drugs are used with Selanz, they may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:
- Ampicillin. Selanz can prevent your body from absorbing ampicillin well. As a result, ampicillin may not work as well to treat your infection.
- Ketoconazole and itraconazole. Selanz can prevent your body from absorbing these antifungals well. Ketoconazole may not work as well to treat your infection.
- Mycophenolate mofetil (MMF). Selanz can prevent your body from absorbing MMF properly. As a result, MMF may not work as well. It isn’t known how this interaction may affect your risk of organ rejection. If you take MMF, ask your doctor whether Selanz is safe for you.
- Iron salts. Selanz can prevent your body from absorbing drugs that contain iron well.
- Erlotinib, dasatinib, and nilotinib. Selanz can prevent your body from absorbing these drugs well. As a result, they may not work as well to treat your cancer.
- Theophylline. Selanz may decrease the levels of theophylline in your body. This means that theophylline may not work as well to treat your asthma or chronic obstructive pulmonary disease (COPD). Your doctor may monitor the levels of theophylline in your body.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you’re taking.
Getting the most from your treatment
- Try to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking Selanz on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
- Typical courses of treatment last for one or two weeks if you are taking Selanz for Helicobacter pylori eradication. If you are taking it for acid-related dyspepsia, your treatment will typically last for two to four weeks. It will last for around one or two months if it is for an ulcer. For acid reflux or Zollinger-Ellison syndrome, your treatment will last for as long as is necessary to control your symptoms.
- Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic drinks. If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve. Also, try avoiding eating large meals, as these can make your symptoms worse too.
- If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
- Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
- Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like Selanz are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
- If you buy any medicines 'over-the-counter', always check with a pharmacist that they are safe to take alongside your other medicines.
Capsules (delayed-release): 15 mg, 30 mg
Granules for oral suspension (delayed-release, enteric-coated): 15 mg, 30 mg
Prevpac (combination product for Helicobacter pylori infection): daily pack containing two 30-mg Selanz capsules, four 500-mg amoxicillin capsules, and two 500-mg clarithromycin tablets
Prevacid NapraPAC 375 (combination product for reducing risk of ulcers from nonsteroidal anti-inflammatory drugs ): weekly pack containing seven 15-mg Prevacid capsules and fourteen 375-mg Naprosyn tablets
Prevacid NapraPAC 500 (combination product for reducing risk of ulcers from NSAIDs): weekly pack containing seven 15-mg Prevacid capsules and fourteen 500-mg Naprosyn tablets
Prevacid SoluTab (delayed-release, orally disintegrating tablet): 15 mg, 30 mg
How it works
Selanz belongs to a class of drugs called proton pump inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Selanz works by decreasing the amount of acid produced in your stomach. It does this by blocking the proton pump in the cells of your stomach. The proton pump works in the final step of acid production. When the proton pump is blocked, your stomach makes less acid. This helps to decrease your symptoms.
Selanz oral capsule doesn’t cause drowsiness, but it can cause other side effects.Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Intervention: Monitor INR and prothrombin time. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin. Methotrexate Clinical Impact: Concomitant use of PPIs with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. No formal drug interaction studies of high-dose methotrexate with PPIs have been conducted . Intervention: A temporary withdrawal of PREVACID or PREVACID SoluTab may be considered in some patients receiving high-dose methotrexate. Digoxin Clinical Impact: Potential for increased exposure of digoxin. Intervention: Monitor digoxin concentrations. Dose adjustment of digoxin may be needed to maintain therapeutic drug concentrations. See prescribing information for digoxin. Theophylline Clinical Impact: Increased clearance of theophylline . Intervention: Individual patients may require additional titration of their theophylline dosage when PREVACID or PREVACID SoluTab is started or stopped to ensure clinically effective blood concentrations. Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib,mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Selanz can reduce the absorption of other drugs due to its effect on reducing intragastric acidity. Intervention:
Prevacid is marketed under the brand names Prevacid, Prevacid 24hour, and Prevacid Solutab.
Selanz is also available under the name First-Selanz.
Regular Prevacid capsules are available in 15 and 30 milligrams (mg). Prevacid 24hour and Prevacid Solutab are delayed release drugs that also come in both 15 and 30 mg.
Prevacid SoluTab dissolves under the tongue. First-Selanz is a powder that is made into an oral suspension.
Prevacid 24hour should be taken only once every 24 hours for 14 days. It may take up to four days for the full effect.
Do not take more than one tablet every 24 hours.
If you are taking the over-the-counter medication, stop taking after 14 days and call your doctor if there has been no change in your condition.
Allow at least four months before starting another 14-day treatment with Prevacid 24hour.
Call your doctor if you have additional symptoms and need treatment before the four months have passed.
Consult a doctor before giving Prevacid to a child. Children under age 1 should not take this drug.