For erosive esophagitis, doctors can prescribe tablets or oral suspension Segregam.
Adults can take 20 mg or 40 mg daily depending on the severity of the condition. Doctors will typically prescribe Segregam for 8 weeks.
If the drug is not effective after 8 weeks, a person can, in some cases, continue taking the lowest effective dosage for another 8 weeks.
Experience in patients taking very high doses of PROTONIX (greater than 240 mg) is limited. Spontaneous post-marketing reports of overdose are generally within the known safety profile of PROTONIX.
Segregam is not removed by hemodialysis. In case of overdosage, treatment should be symptomatic and supportive.
Single oral doses of Segregam at 709 mg/kg, 798 mg/kg, and 887 mg/kg were lethal to mice, rats, and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
How long will I take it for?
If you buy Segregam from a pharmacy, you can usually take it for up to 2 weeks. After 2 weeks:
- if your symptoms have improved - you can take it for another 2 weeks
- if your symptoms haven't improved - or they are worse, speak to a doctor before taking any more Segregam
Do not take Segregam for more than 4 weeks without speaking to your doctor first. If your symptoms haven't improved, you may need some tests to find out what's causing them.
If you take it on prescription, you may only need to take it for a few weeks or months, depending on your illness. Sometimes your doctor may advise you to take it for longer, even for many years.
Your doctor may suggest taking Segregam only when you have symptoms. This means you won't have to take it every day. Once you feel better, you can stop taking it - often after a few days or weeks. Taking Segregam this way isn't suitable for everyone. Speak to your doctor about what's best for you.
Some people taking warfarin with Segregam can experience increases in INR and prothrombin time (PT). This can lead to an increased risk of severe bleeding. If you take these drugs together, your doctor should monitor you for increases in INR and PT.
Can Segregam cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Segregam. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
What is the dosage for Protonix?
- Segregam used for treatment GERD and healing erosive esophagitis the recommended dose for adults is 40 mg daily for 4-8 weeks.
- The dose for treating Zollinger-Ellison syndrome is 40 mg twice daily.
- It generally is recommended that tablets be taken approximately 30 minutes prior to meals for maximal effectiveness. Tablets should be swallowed whole and should not be crushed, split or chewed.
What are the possible side effects of Segregam (Protonix, Protonix IV)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe stomach pain, diarrhea that is watery or bloody;
- sudden pain or trouble moving your hip, wrist, or back;
- bruising or swelling where intravenous Segregam was injected;
- kidney problems--urinating less than usual, blood in your urine, swelling, rapid weight gain;
- low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or
- new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.
Taking Segregam long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.
If you use Segregam for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Common side effects may include:
- headache, dizziness;
- stomach pain, gas, nausea, vomiting, diarrhea;
- joint pain; or
- fever, rash, or cold symptoms (most common in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What should I avoid while using Segregam?
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.