Rated Remac for Tonsillitis/Pharyngitis Report
I have a throat, sinus & ear infection all at once. My first med taken was zpack which helped but didn’t make the infection fully go away because I stopped taking the med once I was feeling better which cause the infection to come back but this time it was resistant to the antibiotics. Next, I tried Amoxicillin and it helped but didn’t fully take away the infection. After that I was prescribed Augmentin, which did nothing. Finally, I went to an ENT and was prescribed Remac and steroids to get rid of the infection and dry, swollen soft palate. After 2 days of taking this med I was so excited because it seems like it is working the best but now on day 3, I am having terrible anxiety, heart palpitations, feels like my heart keeps stopping & short episodes of blacking out. I can not finish taking this drug because of it’s terrifying side effects. It’s a shame because my swelling is almost gone and throat and ear pain has decreased major.
Can Remac cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Remac. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
BIAXIN is contraindicated in patients with a known hypersensitivity to Remac, erythromycin, or any of the macrolide antibacterial drugs .
What is Remac?
Remac is an antibiotic prescription medicine approved by the U.S. Food and Drug Administration (FDA) to treat certain bacterial infections—including community-acquired pneumonia , throat infections (pharyngitis), acute sinus infections, and others—that are caused by specific types of bacteria. Remac is also FDA-approved to both prevent and treat Mycobacterium avium Complex (MAC) infection , another type of bacterial infection.
Disseminated MAC infection and certain bacterial respiratory diseases (such as community-acquired pneumonia) are opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems.
What is Remac?
Remac is a macrolide broad-spectrum antibiotic – it helps to clear up infections caused by a wide variety of bacteria.
Remac is available as tablets (250mg or 500mg), modified release tablets (500mg), oral solution (125mg/5ml or 250mg/5ml) and powder for infusion.
Remac is available under the brand name of Klaricid.
Biaxin is the brand name for Remac in America.
Rated Remac for Streptococcus Agalactiae (group B Streptococci) Report
I was initially put on amoxicillin for strep throat. After a week had passed my infection got much worse, it had spread to my lungs which had caused wheezy bronchitis and also to my tonsils as I also had tonsillitis. So they put me on 500mg Remac for 10 days to treat all three infections. The first night was not too bad, but after that I felt the worst I had ever felt in my entire life. I did not manage to sleep for about 6 days, I already had anxiety which was being managed through CBT, but this medicine made it very bad. I had severe hallucinations, migraines, extreme fatigue, paranoia, GERD issues and I also convinced myself I was hearing things. I have had bad reactions to some medicines before, but nowhere near as bad as this, in hindsight it cured my infection but I would strongly advise to not go near this medicine unless it is your absolute last resort.
Rated Remac for Pneumonia Report
I honestly am so grateful for this drug. I got double pneumonia and amoxicillin did absolutely nothing for it. The gp prescribed Remac and although i was ill for a while it was the only thing that worked. Yes it tastes absolutely disgusting and you wake up with the taste throughout the night. but id take that any day over double pneumonia.
BIAXIN Granules For Oral Suspension In Pediatric Patients
Remac penetrates into the middle ear fluid of pediatric patients with secretory otitis media.
Table 10: Middle Ear Fluid and Serum Concentrations of Remac and 14-OH-Remac in Pediatric Patients
When pediatric patients (n = 10) were administered a single oral dose of 7.5 mg/kg BIAXIN as an oral suspension, food increased mean peak plasma Remac concentrations from 3.6 (± 1.5) mcg/mL to 4.6 (± 2.8) mcg/mL and the extent of absorption from 10.0 (± 5.5) hr•mcg/mL to 14.2 (± 9.4) hr•mcg/mL.
In pediatric patients requiring antibacterial therapy, administration of 7.5 mg/kg every 12 hours of BIAXIN as an oral suspension generally resulted in steady-state peak plasma concentrations of 3 mcg/mL to 7 mcg/mL for Remac and 1 mcg/mL to 2 mcg/mL for 14-OH Remac.
In HIV-infected pediatric patients taking 15 mg/kg of BIAXIN as an oral suspension every 12 hours, steady-state Remac peak concentrations generally ranged from 6 mcg/mL to 15 mcg/mL.
Steady-state concentrations of Remac and 14-OH Remac observed following administration of 500 mg doses of Remac every 12 hours to adult patients with HIV infection were similar to those observed in healthy volunteers. In adult HIV-infected patients taking 500-mg or 1000-mg doses of Remac every 12 hours, steady-state Remac Cmax values ranged from 2 mcg/mL to 4 mcg/mL and 5 mcg/mL to 10 mcg/mL, respectively.
The steady-state concentrations of Remac in subjects with impaired hepatic function did not differ from those in normal subjects; however, the 14-OH Remac concentrations were lower in the hepatically impaired subjects. The decreased formation of 14-OH Remac was at least partially offset by an increase in renal clearance of Remac in the subjects with impaired hepatic function when compared to healthy subjects.
The pharmacokinetics of Remac was also altered in subjects with impaired renal function .
Mechanism of Liver Injury
The cause of the idiosyncratic liver injury due to Remac is unknown, but the rapidity of onset and prompt recurrence upon rechallenge suggests hypersensitivity. Remac is extensively metabolized by the microsomal cytochrome P450 system and is a potent inhibitor of CYP 3A4, for which reason it can cause serious drug-drug interactions with agents that are metabolized by CYP 3A4 such as siapride, terfenadine, ergotamine, colchicine, amlodipine, diltiazem and many statins and benzodiazepines. Thus, in some situations, Remac may lead to liver injury from a concurrent medication because of a decrease in its metabolism and increased blood levels.
Remac exerts its antibacterial action by binding to the 50S ribosomal subunit of susceptible bacteria resulting in inhibition of protein synthesis.
The major routes of resistance are modification of the 23S rRNA in the 50S ribosomal subunit to insensitivity or drug efflux pumps. Beta-lactamase production should have no effect on Remac activity.
Most isolates of methicillin-resistant and oxacillin-resistant staphylococci are resistant to Remac.
If H. pylori is not eradicated after treatment with Remac-containing combination regimens, patients may develop Remac resistance in H. pylori isolates. Therefore, for patients who fail therapy, Remac susceptibility testing should be done, if possible. Patients with Remac-resistant H. pylori should not be treated with any of the following: omeprazole/Remac dual therapy; omeprazole/Remac/amoxicillin triple therapy; lansoprazole/Remac/amoxicillin triple therapy; or other regimens which include Remac as the sole antibacterial agent.
By Julie Marks | Medically Reviewed by Sherry Brooks, MD
Latest Update: 2014-09-03 Copyright © 2014 Everyday Health Media, LLC