Raticina capsules

Raticina

  • Active Ingredient: Ranitidine
  • 300 mg, 150 mg
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What is Raticina?

The active ingredient of Raticina brand is ranitidine. Ranitidine is in a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces. The empirical formula is C13H22N4O3S.HCl, representing a molecular weight of 350.87. Ranitidine HCl USP is a white to pale yellow crystalline powder that is soluble in water. It has a slightly bitter taste and sulfur-like odor. Each Ranitidine tablets, USP 150 mg for oral administration contains 168 mg of Ranitidine HCl USP equivalent to 150 mg of Ranitidine. Each tablet also contains the inactive ingredients magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hypromellose, titanium dioxide, triacetin, and iron oxide red. Each Ranitidine tablets, USP 300 mg for oral administration contains 336 mg of Ranitidine HCl USP equivalent to 300 mg of Ranitidine. Each tablet also contains the inactive ingredients magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hypromellose, titanium dioxide, triacetin, and iron oxide red.

Used for

Raticina is used to treat diseases such as: Cutaneous Mastocytosis, Duodenal Ulcer, Duodenal Ulcer Prophylaxis, Eczema, Erosive Esophagitis, Gastric Ulcer Maintenance Treatment, Gastrointestinal Hemorrhage, GERD, Indigestion, Pathological Hypersecretory Conditions, Stomach Ulcer, Stress Ulcer Prophylaxis, Surgical Prophylaxis, Urticaria, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Raticina include: ; ; ; ; ; ; .

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ranit >
  • What is Raticina, and how does it work (mechanism of action)?
  • What are the uses for Raticina?
  • What are the side effects of Raticina?
  • What is the dosage for Raticina?
  • Which drugs or supplements interact with Raticina?
  • Is Raticina safe to take if I'm pregnant or breastfeeding?
  • What else should I know about Raticina?

What Are Warnings and Precautions for Raticina?

  • Symptom relieve does not rule out presence of gastric malignancy
  • This medication contains Raticina. Do not take Zantac, Zantac 150 Maximum Strength, or Zantac 75 if you are allergic to Raticina or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

  • Hypersensitivity to Raticina or components of the formulation

Effects of Drug Abuse

  • Symptom relieve does not rule out presence of gastric malignancy
  • See also "What Are Side Effects Associated with Using Raticina?”

  • Prolonged treatment may lead to B12malabsorption and subsequent vitamin B12 deficiency; degree of deficiency is dose-related and association stronger in females and younger in age (younger than 30 years)
  • See also "What Are Side Effects Associated with Using Raticina?”

  • If gastroesophageal reflux disease does not respond adequately in 6-8 weeks, do not increase dosage; prescribe proton pump inhibitor instead
  • Prolonged treatment may lead to B12 malabsorption and subsequent vitamin B12 deficiency; degree of deficiency is dose-related and association stronger in females and younger in age (younger than 30 years)
  • Use caution in renal impairment; adjust dosage
  • Use caution in hepatic impairment
  • Elevation of ALT levels reported with higher doses (greater than 100 mg) or prolonged IV therapy (longer than 5 days); monitor for ALT levels for the remainder of treatment
  • Avoid in patients with acuteporphyria; may precipitate attack
  • Symptom relieve does not rule out presence of gastric malignancy
  • Reversible state of confusion reported with use (linked to age over 50 years and renal or hepatic impairment); clears within 3-4 days after discontinuation

  • Use of Raticina in pregnancy may be acceptable
  • Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk
  • Raticina transfers into breast milk
  • Discontinue use of Raticina if lactating and use caution

What other drugs will affect Raticina?

Before taking Raticina, tell your doctor if you are taking triazolam (Halcion). You may not be able to use this medicine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs that can interact with Raticina. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important

Supplies of Raticina are currently very limited. This is due to a possible risk with the ingredients.

Try to speak to your doctor before your Raticina runs out. There are similar medicines they can prescribe for you if you still need it. In the meantime, keep taking your medicine as usual.

If you have any concerns, speak to your pharmacist or doctor.

Raticina reduces the amount of acid your stomach makes.

It's used for indigestion and heartburn and acid reflux. It is also used for gastro-oesophageal reflux disease (GORD) - this is when you keep getting acid reflux. Raticina is also taken to prevent and treat stomach ulcers.

Sometimes, Raticina is taken for a rare illness caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.

Raticina comes as tablets, soluble (dispersible) tablets that dissolve in water to make a drink, or as a liquid that you drink.

All types of Raticina are available on prescription. You can also buy the lowest strength 75mg tablets from pharmacies and supermarkets.

What are the possible s >

Stop using Raticina and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Raticina and call your doctor at once if you have a serious side effect such as:

  • chest pain, fever, feeling short of breath, coughing up green or yellow mucus;
  • easy bruising or bleeding, unusual weakness;
  • fast or slow heart rate;
  • problems with your vision;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • headache (may be severe);
  • drowsiness, dizziness;
  • sleep problems (insomnia);
  • decreased sex drive, impotence, or difficulty having an orgasm; or
  • swollen or tender breasts (in men);
  • nausea, vomiting, stomach pain; or
  • diarrhea or constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I take Raticina?

Take Raticina exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor's directions about the type of antacid to use, and when to use it.

Do not crush, chew, or break an effervescent tablet, and do not allow it to dissolve on your tongue. The 25-milligram effervescent tablet must be dissolved in at least 1 teaspoon of water before swallowing. The150-milligram effervescent tablet should be dissolved in 6 to 8 ounces of water.

Allow the effervescent tablet to dissolve completely in the water, and then drink the entire mixture. If you are giving this medicine to a child, you may draw the liquid mixture into a medicine dropper and empty the dropper into the child's mouth.

Raticina granules should be mixed with 6 to 8 ounces of water before drinking.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

It may take up to 8 weeks before your ulcer heals. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 6 weeks of treatment.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Raticina.

Store at room temperature away from moisture, heat, and light.

Mixing Raticina with herbal remedies and supplements

There isn't enough research to know if complementary medicines and herbal remedies are safe to take with Raticina.

What is ranit >

Raticina belongs to a group of drugs called histamine-2 blockers. It works by reducing the amount of acid your stomach produces.

Raticina is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome.

Raticina also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

What Is Raticina and How Does It Work?

Raticina is a prescription drug used to treat ulcers of the stomach and intestines and to prevent intestinal ulcers from coming back after they have healed. Raticina is also used to treat certain stomach and throat problems such as erosive esophagitis, gastroesophageal reflux disease or GERD, and Zollinger-Ellison syndrome. It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Raticina belongs to a class of drugs known as H2 blockers.

Raticina is available under the following different brand names: Zantac, Zantac 150 Maximum Strength, and Zantac 75.

Dosages of Raticina

Adult and pediatric dosages:

Dosage Considerations -- Should Be Given As Follows:

Adult Dosage Considerations

  • 150 mg orally every 12 hours or 50 mg intramuscular/intravenously every 6-8 hours

  • Treatment: 150 mg orally every 6 hours or 50 mg intermuscular/intravenously every 6-8 hours intermittent bolus or infusion; alternatively, 6.25 mg/hours intravenously by continuous infusion
  • Maintenance of healing: 150 mg orally every 12 hours

  • 150 mg orally every 12 hours, up to 6 g/day used
  • Parenteral: 50 mg (2 mL) intramuscularly or intermittent intravenous bolus or infusion every 6-8 hours, not to exceed 400 mg/day; alternatively, 6.25 mg/hour continuous infusion

Studies pointing to risk date to 1980s

In 2016, Stanford University researchers tested urine samples of 10 people who took a 150-milligram tablet of Zantac and found NDMA levels far greater than the FDA's daily limits.

William Mitch is a Stanford University professor of civil and environmental engineering who studies wastewater converted to drinking water. He said his Zantac-urine study was a "chance finding from a peripheral field" after a study on potential NDMA contamination in drinking water.

He said it should be followed by a more robust study using the FDA's testing methods.

"The challenge is there's so much concern about cancer risk. Could you get approval from someone to eat a Zantac and collect the urine sample?" Mitch said, noting such a request would be odd and ethically challenging, given the drug has a known carcinogen and remains on the market.

Lior Braunstein, a Memorial Sloan Kettering oncologist and researcher, is studying Raticina and cancer risk. He does not want to discuss the study until the findings are published in a peer-reviewed journal, according to Caitlin Hool, a hospital spokeswoman.

Light said studies conducted in the 1980s raised concern about potential safety risks. In a citizen petition to the FDA, Valisure said Zantac's originator, Glaxo Research Group, conducted its own study in 1987 "after numerous studies raised concerns" about Raticina.

The Glaxo study examined stomach contents of people who took the drug. It found people had no significant increase in nitrosamines such as NDMA within 24 hours of taking Raticina.

Light said the study's testing methods were less accurate and researchers discarded stomach samples that contained Raticina. Without those samples, researchers would not find NDMA or nitrosamines that form as a result of taking the drug, Light said.

Light said the Stanford study and his lab's own analysis shows the potential health risk for people who took the drug.

"The negative effect of exposure to this drug and its formation of NDMA is something that has created a huge public health problem," he said, "and we’re going to be dealing with it going forward."


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