Differences between Omeprazole and Zantac
Both of these medicines Zantac and Omeprazole have a common objective: to help in the treatment of gastric troubles. The following diseases can be cured by both:
- Peptic ulcer: This is erosion in the stomach lining or the duodenum.
- Gastric ulcer: This is peptic ulcer located inside the stomach.
- GERD: Gastriesophageal Reflux Disease in which food and the acids in the stomach move upwards towards the esophagus and cause heart burns.
- Any other disease which increases the acid content of the stomach.
Both the medicines are effective in treating these because they both restrict the production of acid in the stomach. They just act in different ways to achieve the same goal.
Zantac or Ranicel belongs to a group of drugs called histamine 2 blockers. That is, Zantac attacks the Histamine receptors in the stomach cells which causes a reduction in acid production in these cells. Zantac is used to treat ulcers in the stomach and intestine. Zantac also treats conditions in which the stomach produces too much acid. It can provide relief to patients who have Gastroesophageal Reflux Disease or any other disease in which the acid from the stomach passes out into the food pipe causing heartburns. Zantac provides relief because it reduces the amount of acid the stomach normally produces. Zantac also has antiemetic effects; because of this, it is prescribed before chemotherapy and in preoperative cases.
Omeprazole falls in a group of drugs called proton pump inhibiters. The proton pump is the Hydrogen/Potassium adenosine triphosphatase enzyme system, which secretes H+ ions in the gastric lumen, thus increasing its acidity. Omeprazole acts by restricting acid production in the stomach by supressing the action of the proton pump.
Like Zantac, it is also used to treat conditions caused by excess acid in the stomach like GERD and heals the damage caused to the esophagus by the stomach acids. Omiprazole may be given together with antibiotics to treat gastric ulcer. However, Omeprazole is not effective in providing immediate relief from heartburns.
The difference between Zantac and Omeprazole:
The main difference between them is that they have different modes of operation: Zantac acts on the histamine receptors while Omeprazole acts on the proton pump. Secondly, Zantac provides immediate relief and is used to reduce the chances of acidity, while the Omeprazole is considered more effective in the long term. In cases of peptic and gastric ulcers, Omeprazole is preferred, while Zantac is more commonly used for its antiemetic effects.
What is the dosage for Ranicel?
Ranicel may be taken with or without food.
- Usual oral doses for treating ulcers and GERD are 150 mg twice daily or 300 mg at bedtime. The maintenance dose is 150 mg daily.
- Erosive esophagitis is treated with 150 mg 4 times daily.
- Zollinger-Ellison syndrome may be treated with as much as 6 g daily.
- Heartburn is treated with 75 mg or 150 mg once or twice daily 30-60 minutes before consuming meals or beverages that cause heartburn.
Self-medication should not last longer than 2 weeks unless advised by a physician.
What Other Drugs Interact with Ranicel?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
There are no severe interactions with Ranicel.
Serious Interactions of Ranicel include:
Ranicel has moderate interactions with at least 51 different drugs.
Mild Interactions of Ranicel include:
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Ranicel and breastfeeding
Ranicel is safe to take while you're breastfeeding. It passes into breast milk, but only in small amounts which aren't harmful to the baby.
However, if your baby is premature or has health problems check with your doctor first.
Q. Will Ranicel be back on the market?
A. Several manufacturers have voluntarily recalled Ranicel. Information about all Ranicel recalls can be found on FDA’s recall webpage. Some companies have recalled because of levels of NDMA above the acceptable daily intake (96 ng per day or 0.32 ppm), while some have recalled because of the potential of NDMA in the drug.
As manufacturers demonstrate levels of NDMA below the acceptable daily intake, their rainitidine medicines may become available.
Q: I'm pregnant. Is it safe to take Zantac during my first trimester?
A: Zantac (Ranicel) is classified as pregnancy category B, which means that it's been tested in pregnant lab animals and hasn't been shown to cause any damage to the fetus in those animals. However, it hasn't been tested in humans, and there is a lack of documentation to form any conclusions as to whether it will interfere with the development of a human fetus. Please consult your doctor about the safest treatments for excess stomach acid. For more information on Zantac, go to //www.everydayhealth.com/drugs/zantac. Matt Curley, PharmD MSCIS
Walmart has become the latest store to halt sales of the popular heartburn treatment Zantac after health regulators warned about a potentially dangerous contaminant in the drug. (Oct. 4) AP, AP
The stomach-acid-blocking drug Zantac was prescribed more than 15 million times a year with little worry about the safety of the medication, available for decades.
But it's been harder to get the drug since September, when the Food and Drug Administration said testing showed versions of Zantac and its generic, Ranicel, contained a probable carcinogen. The French drugmaker Sanofi recalled Zantac from drugstores and retailers' shelves. A half-dozen generic drugmakers pulled Ranicel from the market.
How did a drug routinely used by millions of heartburn sufferers and available with or without a prescription become a potential cancer risk? It’s a question the FDA, drug manufacturers and consumers want answered.
“Every patient who comes into my office now, it’s almost the first thing that comes out in conversation: ‘What about Ranicel? What should I do with the medication? Should I come off of it or not?’ ” said Jon Ernstoff, a gastroenterologist in Meriden, Connecticut.
In September, the FDA found unacceptable levels of the probable carcinogen, NDMA, or nitrosodimethylamine, in Zantac and generic medications. The regulatory agency wants manufacturers to test and recall the drugs if NDMA levels exceed its standards. The FDA extended the voluntary recall to a similar drug, nizatidine, sold under the brand name Axid, if testing shows NDMA exceeding daily limits.
The FDA said consumers might want to choose different medications. The agency tested samples of over-the-counter alternatives such as Pepcid, Tagamet, Nexium, Prevacid and Prilosec and found no NDMA.
The agency's investigation of Ranicel seeks to uncover the root cause of NDMA found in the commonly used medication. Researchers at Memorial Sloan Kettering Cancer Center in New York are assessing whether people who used Zantac or its generics face a greater cancer risk.
The warning first came after Valisure, a Connecticut-based online pharmacy and laboratory, discovered NDMA in several forms of the drug and alerted the FDA. The private company said clues of the drug's potential risk can be traced to medical studies published since the early 1980s.
NDMA is the same carcinogen that led to a widespread recall beginning in July 2018 of the blood-pressure-lowering drugs valsartan and losartan. The blood pressure recall stemmed from a new manufacturing process first used by a drug ingredient factory in China.
Zantac's risk appears to be the unstable nature of the drug itself, said Valisure CEO David Light.
“This isn’t some new, bad manufacturing process overseas like what happened with valsartan and losartan,” Light said. “It is our view that this problem with Ranicel has been there since the 1980s.
"It's a much more serious issue."
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Ranicel.