Capsules (delayed-release): 15 mg, 30 mg
Granules for oral suspension (delayed-release, enteric-coated): 15 mg, 30 mg
Prevpac (combination product for Helicobacter pylori infection): daily pack containing two 30-mg Prezal capsules, four 500-mg amoxicillin capsules, and two 500-mg clarithromycin tablets
Prevacid NapraPAC 375 (combination product for reducing risk of ulcers from nonsteroidal anti-inflammatory drugs ): weekly pack containing seven 15-mg Prevacid capsules and fourteen 375-mg Naprosyn tablets
Prevacid NapraPAC 500 (combination product for reducing risk of ulcers from NSAIDs): weekly pack containing seven 15-mg Prevacid capsules and fourteen 500-mg Naprosyn tablets
Prevacid SoluTab (delayed-release, orally disintegrating tablet): 15 mg, 30 mg
Tables 2 and 3 include drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with PREVACID or PREVACID SoluTab and instructions for preventing or managing them.
Consult the labeling of concomitantly used drugs to obtain further information about interactions with PPIs.
Table 2. Clinically Relevant Interactions Affecting Drugs Co-Administered with PREVACID orPREVACID SoluTab and Interactions with DiagnosticsAntiretroviralsClinical Impact:The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known.
- Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with Prezal may reduce antiviral effect and promote the development of drug resistance.
- Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with Prezal may increase toxicity of the antiretroviral drugs.
- There are other antiretroviral drugs which do not result in clinically relevant interactions with Prezal.
Mixing Prezal with herbal remedies and supplements
Do not take St John's wort, the herbal remedy for depression, while you're taking Prezal. St John's wort may stop Prezal working as well as it should.
For Healthcare Professionals
Applies to Prezal: compounding powder, intravenous powder for injection, oral delayed release capsule, oral granule for reconstitution, oral suspension, oral tablet disintegrating
Serious side effects
Serious side effects are rare and happen in less than 1 in 1,000 people.
Call a doctor straight away if you have:
- joint pain along with a red skin rash, especially in parts of your body exposed to the sun, such as your arms, cheeks and nose - these can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you've been taking Prezal for a long time
- stomach pain that seems to be getting worse - this can be a sign of an inflamed liver or pancreas
What is Prezal, and how does it work (mechanism of action)?
Prezal is in a class of drugs called proton pump inhibitors (PPI) which block the production of acid by the stomach. Other drugs in the same class include
Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome that are caused by stomach acid. Prezal, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.
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Prevacid is marketed under the brand names Prevacid, Prevacid 24hour, and Prevacid Solutab.
Prezal is also available under the name First-Prezal.
Regular Prevacid capsules are available in 15 and 30 milligrams (mg). Prevacid 24hour and Prevacid Solutab are delayed release drugs that also come in both 15 and 30 mg.
Prevacid SoluTab dissolves under the tongue. First-Prezal is a powder that is made into an oral suspension.
Prevacid 24hour should be taken only once every 24 hours for 14 days. It may take up to four days for the full effect.
Do not take more than one tablet every 24 hours.
If you are taking the over-the-counter medication, stop taking after 14 days and call your doctor if there has been no change in your condition.
Allow at least four months before starting another 14-day treatment with Prevacid 24hour.
Call your doctor if you have additional symptoms and need treatment before the four months have passed.
Consult a doctor before giving Prevacid to a child. Children under age 1 should not take this drug.