Praux tablets


  • Active Ingredient: Metoclopramide
  • 10 mg
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What is Praux?

The active ingredient of Praux brand is metoclopramide. Metoclopramide increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Used for

Praux is used to treat diseases such as: Gastroparesis, GERD, Lactation Augmentation, Migraine, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Radiographic Exam, Small Intestine Intubation.

Side Effect

Possible side effects of Praux include: fever; uncontrolled movements of the arms and legs; increase in blood pressure; swelling of the feet or lower legs; twisting movements of the body; stiffness of the arms or legs; lip smacking or puckering; shuffling walk.

How to Buy Praux tablets online?

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Important Information

Do not use this medicine if you've ever had muscle movement problems after using Praux or similar medicines, or if you've had a movement disorder called tardive dyskinesia. You also should not use this medicine if you've had stomach or intestinal problems (a blockage, bleeding, or a hole or tear), epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).

NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use can cause a serious movement disorder that may not be reversible. The longer you use Praux, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).

Before you take Praux, tell your doctor if you have kidney or liver disease, congestive heart failure, high blood pressure, diabetes, Parkinson's disease, or a history of depression.

Do not drink alcohol. It can increase some of the side effects of Praux.

Stop using Praux and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes).

Before taking Praux

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Praux it is important that your doctor or pharmacist knows:

    What is metoclopram >

    Praux increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

    Praux oral (taken by mouth) is used for 4 to 12 weeks to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief.

    Praux oral is also used to treat gastroparesis (slow stomach emptying) in people with diabetes, which can cause heartburn and stomach discomfort after meals.

    Praux injection is used to treat severe diabetic gastroparesis. The injection is also used to prevent nausea and vomiting caused by chemotherapy or surgery, or to aid in certain medical procedures involving the stomach or intestines.

    25.1.4 Promotility agents

    Praux (FDA category B) is a prokinetic, dopamine agonist which may be useful in the treatment of GERD by increasing LES pressure, improving esophageal acid clearance, and promoting gastric emptying. Use of Praux is often limited by its poor tolerability and the risk for extra-pyramidal side effects. It has been associated in rare cases with tardive dyskinesia, causing the FDA to issue a black-box warning concerning the use of this drug in 2009. The risk of the development of this complication increases with high dose or long-term use of the drug and continues even after the drug has been discontinued.

    What are the possible side effects of Praux:

    Stop giving Praux and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives), uncontrollable spasms of the legs, lips, jaw, tongue, face or other body part, anxiety, agitation, insomnia, depression, yellowing of the skin or eyes, seizures. Other less serious side effects that may occur include nausea or diarrhea, dizziness, drowsiness, confusion, fluid retention, increased urination. Continue to give the medication and contact your veterinarian.

    How should I use Praux?

    Take Praux exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Use the medicine exactly as directed.

    A Praux injection is given into a muscle or as an infusion into a vein. A healthcare provider will give the injection, usually during surgery, chemotherapy, or a medical procedure.

    Praux oral is taken for only 4 to 12 weeks.

    NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use of Praux can cause a serious movement disorder that may not be reversible. The longer you use Praux, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).

    Praux is usually taken 30 minutes before meals and at bedtime, or only with meals that usually cause heartburn. Follow your doctor's dosing instructions very carefully.

    Do not use two different forms of Praux (such as tablets and oral syrup) at the same time.

    Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

    To take the orally disintegrating tablet (ODT):

    Remove a tablet from its blister pack only when you are ready to take the tablet. Use dry hands and take care not to damage a tablet while pushing it out of the blister.

    Place the tablet in your mouth and allow it to dissolve, without chewing or swallowing it whole. You may sip liquid if needed to help swallow the dissolved tablet.

    Store at room temperature in a tightly-closed container, away from moisture and heat. Keep the bottle tightly closed.

    After you stop taking Praux, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness.


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    Further information

    Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Praux only for the indication prescribed.

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

    Copyright 1996-2019 Cerner Multum, Inc. Version: 12.01.

    What are the uses for Praux?

    Praux is a prescription medicine used in adults:

    • to relieve heartburn symptoms with gastroesophageal reflux when certain other treatments do not work
    • to relieve the symptoms of slow stomach emptying in people with diabetes

    Getting the most from your treatment

    • If you buy any medicines, check with a pharmacist that they are safe to take with Praux. This is because Praux can interfere with the way other medicines are absorbed by your body.
    • Try to keep any regular appointments with your doctor. Praux will only be prescribed for a short while (no more than five days) and your doctor may want to check on your progress afterwards.
    • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking Praux, as it can interfere with some anaesthetics.
    • If you drink alcohol, ask your doctor for advice. Your doctor may recommend you do not drink alcohol while you are on Praux, as the side-effects of both the medicine and alcohol can be increased.

    Carcinogenesis, Mutagenesis, Impairment Of Fertility

    A 77-week study was conducted in rats with oral doses up to about 40 times the maximum recommended human daily dose. Praux elevates prolactin levels and the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin-dependent in vitro, a factor of potential importance if the prescription of Praux is contemplated in a patient with previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported with prolactin-elevating drugs, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of prolactinstimulating neuroleptic drugs and Praux. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is too limited to be conclusive at this time.

    An Ames mutagenicity test performed on Praux was negative.

    Benzam > Praux is the most commonly used drug in this class. It blocks type 2 dopamine receptors and 5-HT 3 serotonin receptors (when used in higher doses used to prevent CINV) in the chemoreceptor trigger zone, increases lower esophageal sphincter tone, and enhances bowel and gastric motility. The usual recommended doses are 20 to 40 mg orally every 4 to 6 hours (conventional dose) or 2 to 3 mg/kg (high dose). 64 Praux crosses the blood-brain barrier, and side effects include extrapyramidal reactions such as acute dystonia, akathisia, and possible irreversible tardive dyskinesia, especially with prolonged use of high doses and in the elderly. Diphenhydramine or hydroxyzine can be used to antagonize the dopaminergic toxicity of Praux. In addition, Praux can lower the seizure threshold and increase the risk of convulsions in patients with epilepsy. 37 In the past, Praux combined with dexamethasone was the antiemetic regimen of choice for preventing delayed CINV, 65,66 but it has largely been replaced by the use of 5-HT 3 antagonists and aprepitant.

    Where can I get more information:

    Your pharmacist has additional information about Praux written for health professionals that you may read.

    Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.

    For the Consumer

    Applies to Praux: oral solution, oral tablet, oral tablet disintegrating

    Other dosage forms:

    What should I avoid while giving Praux to my pet:

    Do not use Preventic Flea Collar on your pet while giving this medication.

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    Praux is also available in combination with painkillers for the management of migraine headache in association with nausea. For more information on these medicines please see our separate medicine leaflets Paracetamol and Praux for migraine (Paramax) and Aspirin and Praux for migraine (MigraMax).

    What preparations of Praux are available?

    Tablets: 5 and 10 mg.Syrup: 5 mg/5 ml.Injection: 5 mg/ml

    Use In Patients With Renal Or Hepatic Impairment

    Since Praux is excreted principally through the kidneys, in those patients whose creatinine clearance is below 40 mL/min, therapy should be initiated at approximately one-half the recommended dosage. Depending upon clinical efficacy and safety considerations, the dosage may be increased or decreased as appropriate.

    See OVERDOSE section for information regarding dialysis.

    Praux undergoes minimal hepatic metabolism, except for simple conjugation. Its safe use has been described in patients with advanced liver disease whose renal function was normal.


    The incidence of side effects correlates with dose and duration of Praux therapy.

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