Pantopan tablets

Pantopan

  • Active Ingredient: Pantoprazole
  • 40 mg, 20 mg
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What is Pantopan?

The active ingredient of Pantopan brand is pantoprazole. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium USP is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent. The rate of degradation increases with decreasing pH. At ambient temperature, the degradation half-life is approximately 2.8 hours at pH 5 and approximately 220 hours at pH 7.8. Pantoprazole sodium USP is supplied as a delayed-release tablet, available in two strengths 20 mg Pantoprazole (equivalent to 22.56 mg of Pantoprazole sodium USP) and 40 mg Pantoprazole (equivalent to 45.1 mg of Pantoprazole sodium USP). Pantoprazole sodium delayed-release tablets, USP contain the following inactive ingredients: calcium stearate, crospovidone, ferric oxide, hydroxypropyl cellulose, hypromellose, mannitol, methacrylic acid copolymer dispersion, sodium carbonate, and triethyl citrate. The tablets are imprinted with brown ink containing ammonium hydroxide, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, N-butyl alcohol, propylene glycol, and shellac glaze in ethanol. Pantoprazole sodium delayed-release tablets (40 mg and 20 mg) complies USP dissolution test 3.

Used for

Pantopan is used to treat diseases such as: Barrett's Esophagus, Dumping Syndrome, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Peptic Ulcer, Stomach Ulcer, Stress Ulcer Prophylaxis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Pantopan include: nausea; increased thirst; swollen glands; fruit-like breath odor; unexplained weight loss; joint pain; drowsiness; increased hunger.

How to Buy Pantopan tablets online?

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What else should I know about Protonix?

Protonix is available as:

  • Tablets (Delayed Release): 20, 40 mg.
  • Suspension: 40 mg.
  • Injection: 40 mg

Pantopan should be stored at room temperature, 15 C to 30 C (59 F to 86 F). Keep away from moisture.

Pantopan is available in generic form, and is available over the counter (OTC) or by a prescription from your doctor.

Summary

Pantopan, brand name Protonix, is a drug that belongs to the class of drugs called proton pump inhibitors (PPIs). Protonix is used for the treatment of GERD (gastroesophageal reflux disease), stomach (peptic) and duodenum ulcers, and Zollinger-Ellison syndrome. Side effects of Protonix include phototoxicity (sensitivity to light) dizziness, rash, nausea, vomiting, diarrhea constipation, headaches, stomach pain, gas, dizziness, and joint pain. Serious side effects of Protonix are live damage, rhabdomyolysis (muscle breakdown), pancreatitis, and reduces levels of blood cells. Adverse effects and risks of Protonix used in high doses and long-term (one year or longer) include osteoporosis, C. diff infection, low levels of magnesium, and heart attacks.

What is Pantopan?

Pantopan is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Pantopan is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Pantopan is usually given for up to 8 weeks at a time while your esophagus heals.

Pantopan is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

On this page

  1. About Pantopan
  2. Key facts
  3. Who can and can't take Pantopan
  4. How and when to take it
  5. Side effects
  6. How to cope with side effects
  7. Pregnancy and breastfeeding
  8. Cautions with other medicines
  9. Common questions

2. Key facts

  • It's usual to take Pantopan once a day in the morning.
  • Common side effects include headaches, constipation or diarrhoea, wind, stomach pain, feeling or being sick. These tend to be mild and go away when you stop taking the medicine.
  • If you've bought Pantopan without a prescription and your symptoms don't improve after 2 weeks, see a doctor before taking any more.
  • Pantopan isn't usually recommended during pregnancy.
  • Pantopan is also called by the brand name Pantoloc Control.

How much will I take?

Each tablet contains 20mg or 40mg of Pantopan. You can buy Pantopan 20mg tablets from pharmacies. These are suitable for the short-term treatment of heartburn and acid reflux in adults.

Liquid Pantopan can be prescribed for people who cannot swallow tablets. It will come with a syringe or spoon to help you take the right amount. If you don't have a syringe or spoon, ask your pharmacist for one.

The usual dose to treat:

  • heartburn and acid reflux is 20mg a day
  • gastro-oesophageal reflux disease is 20mg to 40mg a day
  • stomach ulcers is 20mg to 40mg a day
  • Zollinger-Ellison syndrome is 40mg to 80mg a day - this can increase to 160mg a day depending on how well it works for you

Kidney conditions

Taking Pantopan can lead to a kidney condition called acute interstitial nephritis. This may occur in people with a sensitivity to PPIs.

If a doctor detects this condition, they will stop the medication immediately.

What is the most important information I should know about Pantopan (Protonix, Protonix IV)?

Pantopan can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Pantopan may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

What is Pantopan (Protonix, Protonix IV)?

Pantopan is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Pantopan is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Pantopan is usually given for up to 8 weeks at a time while your esophagus heals.

Pantopan is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

Pantopan is not for immediate relief of heartburn.

Pantopan may also be used for purposes not listed in this medication guide.

Drugs affected by stomach pH

Pantopan affects stomach acid levels. As a result, it can reduce your body’s absorption of certain drugs that are sensitive to the effects of decreased stomach acid. This effect can make these drugs less effective.

Examples of these drugs include:

  • ketoconazole
  • ampicillin
  • atazanavir
  • iron salts
  • erlotinib
  • mycophenolate mofetil

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Pantopan only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 19.02.

How to use Pantopan SODIUM

Read the Medication Guide provided by your pharmacist before you start taking Pantopan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. Dosage and length of treatment are based on your medical condition and response to treatment.

If you are taking the tablets, you may take them with or without food. Swallow the tablets whole. Do not split, crush, or chew the medication. Doing so may destroy the drug.

If you are taking the granules, take your dose 30 minutes before a meal. To take it by mouth, open the packet and mix the granules in applesauce or apple juice. Do not mix with other foods or liquids. Do not crush or chew the granules. Sprinkle the granules on 1 teaspoon (5 milliliters) of applesauce and swallow all of the mixture right away (within 10 minutes). Follow with sips of water. Or you can mix the granules with 1 teaspoon (5 milliliters) of apple juice in a small cup, stir for 5 seconds, and swallow all of the mixture right away. To make sure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules, and swallow the juice. Do not prepare the mixture ahead of time for later use.

If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it.

If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take Pantopan at least 30 minutes before sucralfate.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better.

Tell your doctor if your condition persists or worsens. The risk of side effects goes up over time. Ask your doctor how long you should take this medication.

Why it’s used

Pantopan oral tablet is used to reduce the amount of stomach acid your body makes. It helps treat painful symptoms caused by conditions such as gastroesophageal reflux disease (GERD). With GERD, gastric juices flow upward from your stomach and into the esophagus.

Pantopan oral tablet is also used to treat other conditions in which the stomach makes excess acid, such as Zollinger-Ellison syndrome.

Nursing Mothers

Pantopan and its metabolites are excreted in the milk of rats. Pantopan excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose of Pantopan sodium. The clinical relevance of this finding is not known. Many drugs which are excreted in human milk have a potential for serious adverse reactions in nursing infants. Based on the potential for tumorigenicity shown for Pantopan sodium in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

Pantopan to reduce stomach ac >About Pantopan
  • Before taking Pantopan
  • How to take Pantopan
  • Getting the most from your treatment
  • Can Pantopan cause problems?
  • How to store Pantopan
  • Important information about all medicines
  • Pantopan dosing information

    Usual Adult Dose for Erosive Esophagitis:

    Treatment of Erosive Esophagitis: 40 mg orally once a day for up to 8 weeks; however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established.

    Maintenance of Healing of Erosive Esophagitis: 40 mg orally once a day. Controlled studies have been limited to 12 months of Pantopan therapy.

    Usual Adult Dose for Gastroesophageal Reflux Disease:

    Parenteral: 40 mg once a day for 7 to 10 days, administered via intravenous infusion over a period of 15 minutes. Intravenous therapy should be discontinued as soon as the patient is able to resume oral therapy.

    Oral: 40 mg orally once a day, for short-term administration (up to 8 weeks); however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established.

    Usual Adult Dose for Duodenal Ulcer:

    Study (n=54) 40 mg orally once a day, dose was increased every 12 weeks by 40 mg increments to a maximum of 120 mg per day, for 28 weeks. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete duodenal ulcer healing in up to 87% and 94% of patients after 4 weeks and 8 weeks respectively.

    Usual Adult Dose for Gastric Ulcer:

    40 mg orally once a day. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete gastric ulcer healing in up to 87% and 97% of patients after 4 weeks and 8 weeks respectively.

    Usual Adult Dose for Helicobacter pylori Infection:

    Study (n=242) - Triple therapy: 40 mg orally twice daily for 7 days, commonly in conjunction with clarithromycin and either amoxicillin or metronidazole to eradicate Helicobacter pylori, followed with 40 mg Pantopan orally once daily until day 28. Triple therapy has resulted in eradication rates of greater than 95%.

    The QUADRATE Study (n=405) - Quadruple therapy: 40 mg orally twice daily for 7 days, concomitantly with bismuth subcitrate and tetracycline, both four times daily, and metronidazole 200 mg three times daily and 400 mg at bedtime. Helicobacter Pylori eradication was achieved in 82% of patients.

    Usual Adult Dose for Zollinger-Ellison Syndrome:

    Parenteral: 80 mg every 12 hours, administered by 15-minute infusion. Daily doses higher than 240 mg administered in equally divided doses by 15-minute infusion, or administered for more than 6 days have not been studied.

    Oral: 40 mg twice daily, to a maximum of 240 mg per day. Some patients have received treatment with Pantopan for more than 2 years.

    Usual Adult Dose for Stress Ulcer Prophylaxis:

    Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses.

    Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI.

    Usual Adult Dose for Peptic Ulcer:

    Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses.

    Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI.

    What if I take too much?

    It is very unlikely that taking one or two extra doses by accident will cause any problems. However, you should check with your doctor if you have taken too much and have any of these symptoms:

    • flushed skin
    • feeling sweaty
    • a fast heartbeat
    • feeling sleepy
    • blurred vision
    • feeling confused or agitated

    Most people who take Pantopan do not have any side effects. If you do get a side effect, it is usually mild and will go away when you stop taking Pantopan.

    Talk to your pharmacist or doctor if these side effects bother you or don't go away:

    • headaches
    • diarrhoea
    • feeling sick or being sick (nausea or vomiting)
    • constipation
    • stomach pain or wind

    Erosive esophagitis

    For erosive esophagitis, doctors can prescribe tablets or oral suspension Pantopan.

    Adults can take 20 mg or 40 mg daily depending on the severity of the condition. Doctors will typically prescribe Pantopan for 8 weeks.

    If the drug is not effective after 8 weeks, a person can, in some cases, continue taking the lowest effective dosage for another 8 weeks.


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