Headache or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain).
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool.
Rarely, proton pump inhibitors (such as Pantocal) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as change in the amount of urine).
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
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Proton pump inhibitors such as Pantocal stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn. Pantocal is also given as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Pantocal is available on prescription. You can also buy short courses of Pantocal at a pharmacy for the treatment of reflux symptoms (such as heartburn) in adults.
Drugs affected by stomach pH
Pantocal affects stomach acid levels. As a result, it can reduce your body’s absorption of certain drugs that are sensitive to the effects of decreased stomach acid. This effect can make these drugs less effective.
Examples of these drugs include:
- iron salts
- mycophenolate mofetil
Pantocal is the generic name for Protonix, a drug that helps treat problems related to acid reflux and peptic ulcers. It works by decreasing acid in the stomach.
Pantocal is a proton pump inhibitor (PPI). People use it to treat and manage the symptoms of erosive esophagitis and Zollinger–Ellison syndrome.
Doctors also prescribe Pantocal to stop ulcers from forming.
In this article, we take a look at the uses of Pantocal, possible side effects, and warnings when taking this drug.
What other drugs will affect Pantocal (Protonix, Protonix IV)?
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect Pantocal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Due to the chronic nature of GERD, there may be a potential for prolonged administration of PROTONIX. In long-term rodent studies, Pantocal was carcinogenic and caused rare types of gastrointestinal tumors. The relevance of these findings to tumor development in humans is unknown .
How should I use Pantocal (Protonix, Protonix IV)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Use the lowest dose for the shortest amount of time needed to treat your condition.
Pantocal is taken by mouth (oral) or given as an infusion into a vein (injection). A healthcare provider may teach you how to properly use Pantocal injection by yourself.
Pantocal tablets are taken by mouth, with or without food. Pantocal oral granules should be taken 30 minutes before a meal.
Do not crush, chew, or break the tablet. Swallow it whole.
The oral granules should be mixed with applesauce or apple juice and given either by mouth or through a nasogastric (NG) tube.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Pantocal.
Pantocal may also affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use this medicine.
Store this medicine at room temperature away from moisture, heat, and light.
How long will I take it for?
If you buy Pantocal from a pharmacy, you can usually take it for up to 2 weeks. After 2 weeks:
- if your symptoms have improved - you can take it for another 2 weeks
- if your symptoms haven't improved - or they are worse, speak to a doctor before taking any more Pantocal
Do not take Pantocal for more than 4 weeks without speaking to your doctor first. If your symptoms haven't improved, you may need some tests to find out what's causing them.
If you take it on prescription, you may only need to take it for a few weeks or months, depending on your illness. Sometimes your doctor may advise you to take it for longer, even for many years.
Your doctor may suggest taking Pantocal only when you have symptoms. This means you won't have to take it every day. Once you feel better, you can stop taking it - often after a few days or weeks. Taking Pantocal this way isn't suitable for everyone. Speak to your doctor about what's best for you.
Pantocal and metabolites are excreted in milk of rats. Pantocal excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose of Pantocal sodium; clinical relevance of this finding not known; many drugs excreted in human milk have potential for serious adverse reactions in nursing infants; based on potential for tumorigenicity shown for Pantocal sodium in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account benefit of drug to mother
What should I discuss with my healthcare provider before using Pantocal (Protonix, Protonix IV)?
Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.
You should not use this medicine if:
- you also take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); or
- you are allergic to Pantocal or similar medicines (lansoprazole, omeprazole, Nexium, Prevacid, Prilosec, and others).
Tell your doctor if you have ever had:
- low levels of magnesium in your blood;
- lupus; or
- osteoporosis or low bone mineral density.
You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breast-feed while using this medicine.
Pantocal is not approved for use by anyone younger than 5 years old.
2. Key facts
- It's usual to take Pantocal once a day in the morning.
- Common side effects include headaches, constipation or diarrhoea, wind, stomach pain, feeling or being sick. These tend to be mild and go away when you stop taking the medicine.
- If you've bought Pantocal without a prescription and your symptoms don't improve after 2 weeks, see a doctor before taking any more.
- Pantocal isn't usually recommended during pregnancy.
- Pantocal is also called by the brand name Pantoloc Control.
How much will I take?
Each tablet contains 20mg or 40mg of Pantocal. You can buy Pantocal 20mg tablets from pharmacies. These are suitable for the short-term treatment of heartburn and acid reflux in adults.
Liquid Pantocal can be prescribed for people who cannot swallow tablets. It will come with a syringe or spoon to help you take the right amount. If you don't have a syringe or spoon, ask your pharmacist for one.
The usual dose to treat:
- heartburn and acid reflux is 20mg a day
- gastro-oesophageal reflux disease is 20mg to 40mg a day
- stomach ulcers is 20mg to 40mg a day
- Zollinger-Ellison syndrome is 40mg to 80mg a day - this can increase to 160mg a day depending on how well it works for you
Some people taking warfarin with Pantocal can experience increases in INR and prothrombin time (PT). This can lead to an increased risk of severe bleeding. If you take these drugs together, your doctor should monitor you for increases in INR and PT.