Panprabene tablets

Panprabene

  • Active Ingredient: Pantoprazole
  • 40 mg, 20 mg
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What is Panprabene?

The active ingredient of Panprabene brand is pantoprazole. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium USP is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent. The rate of degradation increases with decreasing pH. At ambient temperature, the degradation half-life is approximately 2.8 hours at pH 5 and approximately 220 hours at pH 7.8. Pantoprazole sodium USP is supplied as a delayed-release tablet, available in two strengths 20 mg Pantoprazole (equivalent to 22.56 mg of Pantoprazole sodium USP) and 40 mg Pantoprazole (equivalent to 45.1 mg of Pantoprazole sodium USP). Pantoprazole sodium delayed-release tablets, USP contain the following inactive ingredients: calcium stearate, crospovidone, ferric oxide, hydroxypropyl cellulose, hypromellose, mannitol, methacrylic acid copolymer dispersion, sodium carbonate, and triethyl citrate. The tablets are imprinted with brown ink containing ammonium hydroxide, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, N-butyl alcohol, propylene glycol, and shellac glaze in ethanol. Pantoprazole sodium delayed-release tablets (40 mg and 20 mg) complies USP dissolution test 3.

Used for

Panprabene is used to treat diseases such as: Barrett's Esophagus, Dumping Syndrome, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Peptic Ulcer, Stomach Ulcer, Stress Ulcer Prophylaxis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Panprabene include: hearing loss; flushed, dry skin; pains in the stomach, side, or abdomen, possibly radiating to the back; continuous ringing or buzzing or other unexplained noise in the ears; excess air or gas in the stomach or intestines; pale skin; dark-colored urine; diarrhea.

How to Buy Panprabene tablets online?

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Important Information

Panprabene is not for the immediate relief of heartburn symptoms.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Long-term treatment with Panprabene may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Talk with your doctor if you need long-term Panprabene treatment and you have concerns about vitamin B-12 deficiency.

Panprabene can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Panprabene may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Panprabene only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 19.02.

Where can I get more information (Protonix, Protonix IV)?

Your pharmacist can provide more information about Panprabene.

What Other Drugs Interact with Panprabene?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Panprabene include:

Serious Interactions of Panprabene include:

  • afatinib
  • atazanavir
  • dasatinib
  • delavirdine
  • digoxin
  • edoxaban
  • indinavir
  • itraconazole
  • ivacaftor
  • ketoconazole
  • mesalamine
  • nilotinib
  • nisoldipine
  • pazopanib
  • pomalidomide
  • ponatinib
  • riociguat
  • sofosbuvir/velpatasvir
  • venetoclax

Panprabene has moderate interactions with at least 52 different drugs.

Panprabene has mild interactions with at least 27 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Panprabene Overdose

Evidence on the effects of Panprabene overdose in humans is limited.

Symptoms of overdose in studies of Panprabene in rats, mice, and dogs included:

If you suspect an overdose, you should seek emergency medical attention or call the Poison Help Line at (800) 222-1222.

Why it’s used

Panprabene oral tablet is used to reduce the amount of stomach acid your body makes. It helps treat painful symptoms caused by conditions such as gastroesophageal reflux disease (GERD). With GERD, gastric juices flow upward from your stomach and into the esophagus.

Panprabene oral tablet is also used to treat other conditions in which the stomach makes excess acid, such as Zollinger-Ellison syndrome.

1. About Panprabene

Panprabene reduces the amount of acid your stomach makes.

It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) - GORD is when you keep getting acid reflux. It's also taken to prevent and treat stomach ulcers.

Sometimes, Panprabene is taken for a rare illness caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.

Panprabene comes as tablets. It also comes as liquid that you swallow.

All types of Panprabene are available on prescription. You can buy lower-strength 20mg tablets from pharmacies for heartburn or acid reflux.

What should I avoid while using Panprabene (Protonix, Protonix IV)?

This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

How to take Panprabene

  • Before you start this treatment, read the manufacturer's printed information leaflet from ins >

What Is Panprabene and How Does It Work?

Panprabene is used to treat certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Panprabene belongs to a class of drugs known as proton pump inhibitors (PPIs).

Panprabene may also be used to treat and prevent stomach and intestinal ulcers.

Panprabene is available under the following different brand names: Protonix.

Dosages of Panprabene:

Adult and Pediatric Dosage Forms & Strengths

Powder for injection (Adult Only)

Dosage Considerations – Should be Given as Follows:

Erosive Esophagitis Associated With GERD

  • Treatment: 40 mg orally once/day for 8-16 weeks
  • Maintenance of healing: 40 mg orally once/day
  • Alternatively, 40 mg intravenously (IV) once/day for 7-10 days
  • Safety and efficacy not established
  • 15 kg to less than 40 kg: 20 mg orally once/day for up to 8 weeksv
  • 40 kg or greater: 40 mg orally once/day for up to 8 weeks
  • Short-term Treatment of GERD

    • Oral therapy inappropriate or not possible: 40 mg IV infusion over 15 minutes once/day for 7-10 days; switch to orally once patient able to swallow

    • 40 mg orally once/day; up to 240 mg/day administered in some patients
    • 80 mg IV infusion every 8-12 hours up to 7 days; switch to orally once patient able to swallow

    • Duodenal ulcer: 40 mg orally once/day for 2 weeks
    • Gastric ulcer: 40 mg orally once/day for 4 weeks

    • 40 mg Panprabene, pale yellowish to dark brownish, enteric-coated granules in a unit dose packet

    On this page

    1. About Panprabene
    2. Key facts
    3. Who can and can't take Panprabene
    4. How and when to take it
    5. Side effects
    6. How to cope with side effects
    7. Pregnancy and breastfeeding
    8. Cautions with other medicines
    9. Common questions

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