Pandev tablets


  • Active Ingredient: Pantoprazole
  • 40 mg, 20 mg
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What is Pandev?

The active ingredient of Pandev brand is pantoprazole. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium USP is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent. The rate of degradation increases with decreasing pH. At ambient temperature, the degradation half-life is approximately 2.8 hours at pH 5 and approximately 220 hours at pH 7.8. Pantoprazole sodium USP is supplied as a delayed-release tablet, available in two strengths 20 mg Pantoprazole (equivalent to 22.56 mg of Pantoprazole sodium USP) and 40 mg Pantoprazole (equivalent to 45.1 mg of Pantoprazole sodium USP). Pantoprazole sodium delayed-release tablets, USP contain the following inactive ingredients: calcium stearate, crospovidone, ferric oxide, hydroxypropyl cellulose, hypromellose, mannitol, methacrylic acid copolymer dispersion, sodium carbonate, and triethyl citrate. The tablets are imprinted with brown ink containing ammonium hydroxide, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, N-butyl alcohol, propylene glycol, and shellac glaze in ethanol. Pantoprazole sodium delayed-release tablets (40 mg and 20 mg) complies USP dissolution test 3.

Used for

Pandev is used to treat diseases such as: Barrett's Esophagus, Dumping Syndrome, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Peptic Ulcer, Stomach Ulcer, Stress Ulcer Prophylaxis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Pandev include: loss of appetite; drowsiness; dizziness or lightheadedness; diarrhea; bloody or cloudy urine; dark-colored urine; trouble sleeping.

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Zollinger–Ellison syndrome

When treating chronic conditions such as Zollinger–Ellison syndrome, people should take 40 mg of Pandev twice per day.

Most people tolerate Pandev well, but some may experience the following side effects:

When people use Pandev for long periods, they are at an increased risk of the following side effects:

  • Clostridium difficile diarrhea
  • colitis
  • overgrowth of bacteria in the small intestine
  • bone loss
  • kidney disorders

People who take Pandev for an extended period of time are at risk of the drug becoming carcinogenic and causing rare types of gastrointestinal tumors.

Based on a recent major change to its prescribing information, people are also at increased risk of stomach growths called fundic gland polyps when taking PPIs for a long period — especially for longer than 1 year.

Taking Pandev for extended periods can cause vitamin and mineral deficiencies, such as:

  • vitamin B-12 deficiency
  • iron deficiency
  • calcium deficiency
  • magnesium deficiency

Doctors should follow up with people taking Pandev. After completing the treatment, if a person still has symptoms, the doctors should investigate whether or not the diagnosis was indeed accurate.

Sometimes, people may feel much better after the treatment is complete, but their symptoms may quickly return. Doctors may perform further tests, including an endoscopy.

An endoscopy involves passing a flexible tube with a camera attached, called an endoscope, into the stomach through the mouth to see the inside of the body.

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Call a doctor straight away if you have:

  • joint pain and a red skin rash, especially in parts of your body exposed to the sun, such as your arms, cheeks and nose. These can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you've been taking Pandev for a long time.
  • stomach pain that gets worse, yellow skin (or the whites of your eyes turn yellow), dark pee. These can be signs of liver problems.
  • pain when you pee, peeing less, lower back pain, swollen ankles, and rash or fever. These could be signs of a kidney problem.

What Are Side Effects Associated with Using Pandev?

Common side effects of Pandev include:

Other side effects of Pandev include:

Postmarketing side effects of Pandev reported include:

  • Weakness
  • Fatigue
  • Feeling unwell (malaise)
  • Hepatocellular damage leading to jaundice and hepatic failure
  • Agranulocytosis, pancytopenia
  • Taste disorders (loss of taste, changes in taste)
  • Weight changes
  • Low bloodsodium (hyponatremia)
  • Low blood magnesium
  • Bonefracture
  • Hallucinations
  • Confusion
  • Insomnia
  • Drowsiness
  • Interstitial nephritis
  • Severe dermatologic reactions (some fatal), including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis (some fatal), as well as angioedema (Quincke edema)
  • Cutaneous and systemic lupus erythematosus
  • Cyanocobalamin (vitamin B-12) deficiency
  • Clostridium difficile-associated diarrhea

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What else should I know about Protonix?

Protonix is available as:

  • Tablets (Delayed Release): 20, 40 mg.
  • Suspension: 40 mg.
  • Injection: 40 mg

Pandev should be stored at room temperature, 15 C to 30 C (59 F to 86 F). Keep away from moisture.

Pandev is available in generic form, and is available over the counter (OTC) or by a prescription from your doctor.

How should I use Pandev (Protonix, Protonix IV)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use the lowest dose for the shortest amount of time needed to treat your condition.

Pandev is taken by mouth (oral) or given as an infusion into a vein (injection). A healthcare provider may teach you how to properly use Pandev injection by yourself.

Pandev tablets are taken by mouth, with or without food. Pandev oral granules should be taken 30 minutes before a meal.

Do not crush, chew, or break the tablet. Swallow it whole.

The oral granules should be mixed with applesauce or apple juice and given either by mouth or through a nasogastric (NG) tube.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Pandev.

Pandev may also affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use this medicine.

Store this medicine at room temperature away from moisture, heat, and light.


Due to the chronic nature of GERD, there may be a potential for prolonged administration of PROTONIX. In long-term rodent studies, Pandev was carcinogenic and caused rare types of gastrointestinal tumors. The relevance of these findings to tumor development in humans is unknown .

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Proton pump inhibitors such as Pandev stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn. Pandev is also given as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.

Pandev is available on prescription. You can also buy short courses of Pandev at a pharmacy for the treatment of reflux symptoms (such as heartburn) in adults.

What Other Drugs Interact with Pandev?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Pandev include:

Serious Interactions of Pandev include:

  • afatinib
  • atazanavir
  • dasatinib
  • delavirdine
  • digoxin
  • edoxaban
  • indinavir
  • itraconazole
  • ivacaftor
  • ketoconazole
  • mesalamine
  • nilotinib
  • nisoldipine
  • pazopanib
  • pomalidomide
  • ponatinib
  • riociguat
  • sofosbuvir/velpatasvir
  • venetoclax

Pandev has moderate interactions with at least 52 different drugs.

Pandev has mild interactions with at least 27 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Pandev is the generic name for Protonix, a drug that helps treat problems related to acid reflux and peptic ulcers. It works by decreasing acid in the stomach.

Pandev is a proton pump inhibitor (PPI). People use it to treat and manage the symptoms of erosive esophagitis and Zollinger–Ellison syndrome.

Doctors also prescribe Pandev to stop ulcers from forming.

In this article, we take a look at the uses of Pandev, possible side effects, and warnings when taking this drug.

What Is Pandev (Protonix)?

Pandev is a prescription drug used as a short-term treatment for gastroesophageal reflux disease (GERD).

It's part of a class of medications known as proton-pump inhibitors (PPIs) and is marketed under the brand name Protonix.

GERD is a condition in which the backward flow of acid from the stomach causes heartburn and sometimes injury of the esophagus.

PPIs such as Pandev work by blocking the production of acid made in the stomach.

Pandev may also be used for a longer period of time for maintenance or healing of erosive esophagitis, and to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome.

Pandev was originally approved by the Food and Drug Administration (FDA) in 2000 and is manufactured by the pharmaceutical company Pfizer.

In 2013, Teva Pharmaceutical Industries Ltd. (TEVA) and Sun Pharmaceutical Industries Ltd. were ordered to pay $2.15 billion to Pfizer as a settlement for unauthorized sales of Pandev.

Pandev Overdose

Evidence on the effects of Pandev overdose in humans is limited.

Symptoms of overdose in studies of Pandev in rats, mice, and dogs included:

If you suspect an overdose, you should seek emergency medical attention or call the Poison Help Line at (800) 222-1222.

Is Protonix safe to take if I'm pregnant or breastfeeding?

Use of Pandev in pregnant women has not been adequately evaluated.

Pandev has not been studied in females who are nursing.

  • 40 mg Pandev, pale yellowish to dark brownish, enteric-coated granules in a unit dose packet

How should this medicine be used?

Pandev comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) tablet and as delayed-release granules to take by mouth. The packets of delayed-release granules must be mixed with applesauce or apple juice and taken by mouth or given through a feeding tube. For the treatment and maintenance of GERD, Pandev is usually taken once a day. For the treatment of conditions where the stomach produces too much acid, Pandev is usually taken twice a day. The delayed-release tablets are usually taken with or without food, and the granules are usually taken 30 minutes before a meal. Take Pandev at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Pandev exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. If your doctor has prescribed the 40 mg tablet and it is too big for you to swallow, ask your doctor to prescribe two of the 20 mg tablets instead.

To take the granules, open the packet and either sprinkle the granules onto one teaspoonful of applesauce or into a cup containing one teaspoonful of apple juice. Do not mix the granules with water, other liquids, or other foods. Use all of the granules in the packet; do not divide the granules into smaller doses. If you sprinkle the granules into apple juice, stir the mixture for 5 seconds. Swallow the mixture of applesauce or apple juice and medication right away (within 10 minutes) without chewing or crushing the granules. If you sprinkled the granules on applesauce, take several sips of water to wash the granules down to your stomach. If you sprinkled the granules into apple juice, rinse the cup once or twice with apple juice and drink the apple juice right away to be sure you swallow any leftover granules.

Pandev granules mixed with apple juice may be given through a feeding tube. If you have a feeding tube, ask your doctor how you should take Pandev.

Continue to take Pandev even if you feel well. Do not stop taking Pandev without talking to your doctor. If your condition does not improve or gets worse, call your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Generic Name: Pandev (oral/injection) (pan TOE pra zole)Brand Names: Protonix

Medically reviewed by Last updated on Sep 13, 2018.

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