19 Tips on How to Stop a Cough
Coughing is a reflex that helps a person clear their airways of irritants. There are many causes of an excessive or severe cough including irritants like cigarette and secondhand smoke, pollution, air fresheners, medications like beta blockers and ACE inhibitors, the common cold, GERD, lung cancer, and heart disease. Natural and home remedies to help cure and soothe a cough include stay hydrated, gargle saltwater, use cough drops or lozenges, use herbs and supplements like ginger, mint, licorice, and slippery elm, and don't smoke. Over-the-counter products (OTC)to cure and soothe a cough include cough suppressants and expectorants, and anti-reflux drugs. Prescription drugs that help cure a cough include narcotic medications, antibiotics, inhaled steroids, and anti-reflux drugs like proton pump inhibitors or PPIs, for example, Opaz (Prilosec), rabeprazole (Aciphex), and pantoprazole (Protonix).
Why it’s used
Opaz is used to treat conditions caused by too much acid production in the stomach, such as:
- gastroesophageal reflux disease (GERD)
- erosive esophagitis (acid-related damage to the esophagus, the tube that connects your mouth to your stomach)
- gastric (stomach) ulcers or duodenal ulcers (duodenal ulcers occur in the first part of your small intestine, which is connected to your stomach)
- Zollinger-Ellison syndrome
- stomach infections caused by Helicobacter pylori bacteria.
This drug may be used as part of a combination therapy. This means you may need to take it with other medications.
You just feel crappy all the time.
Using proton-pump inhibitors, especially long term, can put you at a higher risk for vitamin B12 deficiency, a serious bacterial infection called clostridium difficile, bone fractures, and possibly kidney disease, Ravella says. These are very rare side effects, but you want to know the scary stuff too, right? "Because of these safety concerns, I try to keep patients on Opaz for the least amount of time needed," she says.
Although Opaz is a helpful medication to treat acid, there are other natural alternatives that can provide us with the same benefits without the side effects
After oral administration, the onset of the antisecretory effect of Opaz occurs within one hour, with the maximum effect occurring within two hours. Inhibition of secretion is about 50% of maximum at 24 hours and the duration of inhibition lasts up to 72 hours. The antisecretory effect thus lasts far longer than would be expected from the very short (less than one hour) plasma half-life, apparently due to prolonged binding to the parietal H + /K + ATPase enzyme. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days. The inhibitory effect of Opaz on acid secretion increases with repeated once-daily dosing, reaching a plateau after four days.
Results from numerous studies of the antisecretory effect of multiple doses of 20 mg and 40 mg of Opaz in normal volunteers and patients are shown below. The “max” value represents determinations at a time of maximum effect (2-6 hours after dosing), while “min” values are those 24 hours after the last dose of Opaz.
Table 1 : Range of Mean Values from Multiple Studies of the Mean Antisecretory Effects of Opaz After Multiple Daily Dosing
Single daily oral doses of Opaz ranging from a dose of 10 mg to 40 mg have produced 100% inhibition of 24-hour intragastric acidity in some patients.
In patients with chronic renal impairment, whose creatinine clearance ranged between 10 and 62 mL/min/1.73 m², the disposition of Opaz was very similar to that in healthy volunteers, although there was a slight increase in bioavailability. Because urinary excretion is a primary route of excretion of Opaz metabolites, their elimination slowed in proportion to the decreased creatinine clearance. No dose reduction is necessary in patients with renal impairment.
Generic Name: Opaz (oh MEP ra zol)Brand Names: FIRST Opaz, Opaz + SyrSpend SF Alka, PriLOSEC, PriLOSEC OTC, Zegerid> (Original Formulation)
Medically reviewed by Sanjai Sinha, MD Last updated on May 1, 2019.
Opaz 40 mg daily was given in combination with clarithromycin 500 mg every 8 hours to healthy adult male subjects. The steady state plasma concentrations of Opaz were increased (Cmax , AUC0-24 , and T1/2 increases of 30%, 89% and 34% respectively) by the concomitant administration of clarithromycin. The observed increases in Opaz plasma concentration were associated with the following pharmacological effects. The mean 24-hour gastric pH value was 5.2 when Opaz was administered alone and 5.7 when co-administered with clarithromycin.
The plasma levels of clarithromycin and 14-hydroxy-clarithromycin were increased by the concomitant administration of Opaz. For clarithromycin, the mean C max was 10% greater, the mean Cmin was 27% greater, and the mean AUC0-8 was 15% greater when clarithromycin was administered with Opaz than when clarithromycin was administered alone. Similar results were seen for 14-hydroxy-clarithromycin, the mean Cmax was 45% greater, the mean C min was 57% greater, and the mean AUC0-8 was 45% greater. Clarithromycin concentrations in the gastric tissue and mucus were also increased by concomitant administration of Opaz.
Table 2 : Clarithromycin Tissue Concentrations 2 hours after Dose 1