Omeman capsules

Omeman

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Omeman?

The active ingredient of Omeman brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Omeman is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Omeman include: Drowsiness; dryness of the mouth; flushing; fever; difficult, burning, or painful urination; sneezing.

How to Buy Omeman capsules online?

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once daily

Researchers have not conducted studies on the efficacy of Omeman past 12 months.

Doctors suggest taking Omeman 30–60 minutes before a meal. If the doctor recommends taking Omeman twice daily, the person should take it before breakfast and before supper.

The side effects of Omeman include:

Side effects that children may report are similar to those that adults report, except that they tend to complain more about fever and breathing issues, such as pharyngitis and sinus infections.

Q: Is it okay to cut a Prilosec OTC 20 mg tablet in two and take just half a day? The package says not to crush or chew.

A: Prilosec OTC (Omeman) is used for the treatment of acid reflux. It is in the family of proton pump inhibitors that work by disabling some of the acid producing pumps in the stomach to help relieve the symptoms of acid reflux. The prescribing information on Prilosec OTC states that you should not split the caplet in half because it uses an enteric coating to delay the release of medication until it reaches the small intestine, where it will not be destroyed by the stomach acids. If you break the caplet the coating will not work and this will cause the medication to be ineffective. For more information on Prilosec OTC, click on this link: //www.everydayhealth.com/drugs/prilosec For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

The effectiveness of PRILOSEC for the treatment of nonerosive GERD in pediatric patients 1 to 16 years of age is based in part on data obtained from 125 pediatric patients in two uncontrolled Phase III studies .

The first study enrolled 12 pediatric patients 1 to 2 years of age with a history of clinically diagnosed GERD. Patients were administered a single dose of Omeman (0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg) for 8 weeks as an open capsule in 8.4% sodium bicarbonate solution. Seventy-five percent (9/12) of the patients had vomiting/regurgitation episodes decreased from baseline by at least 50%.

The second study enrolled 113 pediatric patients 2 to 16 years of age with a history of symptoms suggestive of nonerosive GERD. Patients were administered a single dose of Omeman (10 mg or 20 mg, based on body weight) for 4 weeks either as an intact capsule or as an open capsule in applesauce. Successful response was defined as no moderate or severe episodes of either pain-related symptoms or vomiting/regurgitation during the last 4 days of treatment. Results showed success rates of 60% (9/15; 10 mg Omeman) and 59% (58/98; 20 mg Omeman), respectively.

Tablets and capsules

Each tablet or capsule contains 10mg, 20mg or 40mg of Omeman.

Swallow tablets and capsules whole with a glass of water or juice.

If you have problems swallowing capsules, you can open some brands of Omeman capsules and mix the granules inside with a small amount of water or fruit juice, or sprinkle them on soft food, such as yoghurt or apple puree.

Do not open capsules that have a special coating (like those made by Dexel). Talk to your pharmacist if you're not sure whether you can open your capsules.

Omeman also comes as a tablet that melts in your mouth.

You can buy Omeman 10mg tablets and capsules from pharmacies.

They're the same as Omeman 10mg tablets and capsules that you get on prescription, but they're meant to be taken only by adults, and only for up to 4 weeks.

Omeman dose (20 mg to 360 mg)

The exact dose of Omeman that you use on a daily basis might impact whether you experience certain side effects, as well as the severities of the side effects that you experience. In most cases, it is believed that the greater the dose of Omeman administered, the more significantly the medication will suppress stomach acid production via blockade of the H+/K+-ATPase enzyme.

Because larger doses of Omeman modulate physiology of the user to a greater extent than smaller doses, side effects tend to be more prevalent and intense among high-dose users. On the other hand, because smaller doses of Omeman won’t alter physiology as significantly, side effects are less likely to occur – and if they do occur – they might be less severe than at high doses.

Medical documentation suggests that Omeman is typically administered at doses between 20 mg and 40 mg per day in adults with gastroesophageal conditions. Assuming you’re using a low or standard dose of Omeman (20 mg to 40 mg per day), the likelihood that you’ll experience unbearable side effects is very low.

That said, some patients may require up to 360 mg of Omeman per day to manage medical symptoms. If you’re taking very high doses of Omeman, you’ll be more likely to end up with intense side effects and harsh adverse reactions due to a larger quantity of the medication modulating physiologic processes (e.g. stomach acid production, nutrient absorption, gut bacteria concentrations, etc.).

Omeman oral capsule is a prescription drug that’s only available in a generic form. It doesn’t have a brand-name version. Omeman is also available as an oral suspension and comes as an over-the-counter (OTC) medication.

Prescription Omeman oral capsule is a delayed-release drug. A delayed-release drug slows the release of the medication until it passes through your stomach. This delay keeps the drug from being inactivated by your stomach.

The pharmacokinetics of Omeman have been investigated in pediatric patients 2 to 16 years of age:

Table 3 : Pharmacokinetic Parameters of Omeman Following Single and Repeated Oral Administration in Pediatric Populations Compared with Adults

Following comparable mg/kg doses of Omeman, younger children (2 to 5 years of age) have lower AUCs than children 6 to 16 years of age or adults; AUCs of the latter two groups did not differ .

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6. How to cope with s >

What to do about:

  • headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking Omeman. Talk to your doctor if they last longer than a week or are severe.
  • feeling sick - try taking Omeman with or after a meal or snack. It may also help if you don't eat rich or spicy food.
  • being sick (vomiting) or diarrhoea - drink plenty of water by having small frequent sips to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee. Do not take any other medicines to treat diarrhoea or vomiting without speaking to a pharmacist or doctor.
  • stomach pain - try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you are in a lot of pain, speak to your pharmacist or doctor.
  • constipation - get more fibre into your diet, such as fresh fruit and vegetables and cereals, and drink plenty of water. Try to exercise, for example, by going for a daily walk or run. If this doesn't help, talk to your pharmacist or doctor
  • wind - steer clear of foods that cause wind, like pulses, lentils, beans and onions. It might also help to eat smaller and more frequent meals, eat and drink slowly, and exercise regularly. Some pharmacy remedies, such as simethicone, may relieve symptoms of wind.

Gastritis Symptoms, Causes, Diet, Home Remedies, Treatment, and Cure

Gastritis (acute and chronic) is an inflammation of the lining of the stomach Some people have no gastritis symptoms, but when they do occur they may include bloating, belching, loss of appetite, nausea, and vomiting. H. pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) are the two main causes of gastritis. Alcohol, caffeine, and high-fat foods also can cause gastritis. Fried, fatty, and spicy foods, and alcohol aggravate gastritis symptoms. Other stomach lining irritants that aggravate symptoms include cigarette smoking, acidic juices, caffeine, tomato products, peppers, and chili powder. Foods that sooth gastritis symptoms, and that help reduce and stop H. pylori infection growth in the stomach include apples, onions, garlic, teas, green leafy vegetables, coconut water, and wheat bran. Gastritis is diagnosed with endoscopy, blood tests, or stool tests. Some people get relief from gastritis symptoms with prescription and non-prescription antacids, histamine blockers like famotidine (Pepcid AC) or ranitidine (Zantac 75), or proton pump inhibitors (PPIs) like Omeman (Prilosec) and esOmeman (Nexium). These drugs will not cure gastritis. Complications of gastritis include gastric cancers, MALT lymphoma, renal problems, and death.

DESCRIPTION

The active ingredient in PRILOSEC (Omeman) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2- sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C17H19N3O3S, with a molecular weight of 345.42. The structural formula is:

Omeman is a white to off-white crystalline powder that melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeman is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions.

The active ingredient in PRILOSEC (Omeman magnesium) for Delayed-Release Oral Suspension, is 5-Methoxy-2-sulfinyl]-1H-benzimidazole, magnesium salt (2:1)

Omeman magnesium is a white to off white powder with a melting point with degradation at 200°C. The salt is slightly soluble (0.25 mg/mL) in water at 25°C, and it is soluble in methanol. The half-life is highly pH dependent.

The empirical formula for Omeman magnesium is (C17H18N3O3S)2 Mg, the molecular weight is 713.12 and the structural formula is:

PRILOSEC is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeman in the form of enteric-coated granules with the following inactive ingredients: cellulose, disodium hydrogen phosphate, hydroxypropyl cellulose, hypromellose, lactose, mannitol, sodium lauryl sulfate and other ingredients. The capsule shells have the following inactive ingredients: gelatin-NF, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide, synthetic black iron oxide, isopropanol, butyl alcohol, FD&C Blue #2, D&C Red #7 Calcium Lake, and, in addition, the 10 mg and 40 mg capsule shells also contain D&C Yellow #10.

Each packet of PRILOSEC For Delayed-Release Oral Suspension contains either 2.8 mg or 11.2 mg of Omeman magnesium (equivalent to 2.5 mg or 10 mg of Omeman), in the form of enteric-coated granules with the following inactive ingredients: glyceryl monostearate, hydroxypropyl cellulose, hypromellose, magnesium stearate, methacrylic acid copolymer C, polysorbate, sugar spheres, talc, and triethyl citrate, and also inactive granules. The inactive granules are composed of the following ingredients: citric acid, crospovidone, dextrose, hydroxypropyl cellulose, iron oxide and xantham gum. The Omeman granules and inactive granules are constituted with water to form a suspension and are given by oral, nasogastric or direct gastric administration.

Concurrent substance use (Interactions)

If you’re using substances with Omeman, it is important to consider that concurrently administered agents might: interfere with the action of Omeman; induce interaction effects; exacerbate Omeman side effects (via synergistic mechanisms); or trigger side effects that have nothing to do with Omeman (yet that you might mistakenly attribute to Omeman).

For example, when Omeman is administered along with clarithromycin and amoxicillin (as part of “triple therapy”) to treat H. pylori infection, risk of side effects like taste perversion and tongue discoloration significantly increase (compared to Omeman monotherapy). The increase in side effect risk among persons using Omeman as part of triple therapy is probably due to synergistic physiologic actions simultaneously exerted by the trio.

The most significant major drug interaction with Omeman is clopiodgrel. Because Omeman inhibits enzymes CYP2C19 and CYP3A4, and clopidogrel requires these enzymes for its metabolism, patients using clopidogrel may not receive therapeutic quantities of clopidogrel metabolites necessary to reduce the risk of cerebrovascular events like heart attack and stroke, possibly leading to cerebrovascular complications.

Other substances might also interact with Omeman pharmacokinetically via CYP450 enzymes (e.g. CYP3A4, CYP2C19, CYP2D6), leading to increased or decreased efficacy. For example, Omeman’s inhibition of CYP3A4 might substantially increase concentrations of benzodiazepines (most of which are metabolized by this enzyme), leading to more potent benzodiazepine effects (and side effects).

If you’re using medications that require CYP450 metabolism, you may be at increased risk of pharmacokinetically-mediated interaction effects. Additionally, concurrent use of medications that require stomach acid for absorption (e.g. ketoconazole) might not work as well. Oppoistely, acid-labile medications (e.g. erythromycin) might be absorbed more extensively when used with Omeman – leading to more significant effects (and side effects).

Have a medical doctor evaluate the concurrent medications that you’re using with Omeman to ensure that you don’t experience pharmacokinetically-mediated interactions and/or synergistic side effects. Moreover, understand that some concurrently-administered substances may cause side effects that you’re wrongfully assuming are from Omeman – or side effects that overlap with and exacerbate the side effects of Omeman.


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