Omax capsules

Omax

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Omax?

The active ingredient of Omax brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Omax is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Omax include: chills; pain; muscle aches or cramps; sore throat; ear congestion; sores, ulcers, or white spots on the lips, in the mouth, or on the genitals; bleeding or crusting sores on the lips; loss of voice.

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Q: Is it okay to cut a Prilosec OTC 20 mg tablet in two and take just half a day? The package says not to crush or chew.

A: Prilosec OTC (Omax) is used for the treatment of acid reflux. It is in the family of proton pump inhibitors that work by disabling some of the acid producing pumps in the stomach to help relieve the symptoms of acid reflux. The prescribing information on Prilosec OTC states that you should not split the caplet in half because it uses an enteric coating to delay the release of medication until it reaches the small intestine, where it will not be destroyed by the stomach acids. If you break the caplet the coating will not work and this will cause the medication to be ineffective. For more information on Prilosec OTC, click on this link: //www.everydayhealth.com/drugs/prilosec For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

Omax is a medication prescribed for the treatment of gastroesophageal reflux disease (GERD); peptic ulcer disease; erosive esophagitis; eosinophilic esophagitis; Zollinger-Ellilson syndrome; and medical conditions associated with gastric acid hypersecretion. In some cases, Omax may also be utilized for the prophylaxis of upper gastrointestinal bleeding (in at-risk populations) and as an adjunct treatment for H. plyori infection.

Historical reports suggest that Omax was first synthesized in the 1970s by chemists employed with the pharmaceutical company “Astra.” After successful clinical trials, Omax received approval in 1988 for use throughout Europe under the trade name “Losec” – and in 1990 for use in the United States under the trade name “Prilosec.”

Though many individuals with gastrointestinal disorders derive noticeable benefit from the ongoing administration of Omax, the medication can sometimes cause unwanted side effects. For this reason, if you’re using Omax, it’s probably a good idea to familiarize yourself with potential side effects and adverse reactions that could emerge during treatment.

Q: Does Prilosec OTC cause gas, bloating, and constipation?

A: Prilosec OTC (Omax) (//www.everydayhealth.com/drugs/prilosec) is in a class of medications called proton pump inhibitors used to treat heartburn and GERD. Prilosec may also be used short term to treat ulcers. (//www.everydayhealth.com/gerd/guide/) Common side effects associated with Prilosec include nausea and diarrhea, headache and stomach pain. A search of prescribing information did list gas and constipation as side effects of Prilosec OTC. This is not a complete list of the side effects associated with Prilosec OTC. Kimberly Hotz, PharmD

Pediatric Patients

For the treatment of GERD and maintenance of healing of erosive esophagitis, the recommended daily dose for pediatric patients 1 to 16 years of age is as follows:

Patient Weight Omax Daily Dose 5

On a per kg basis, the doses of Omax required to heal erosive esophagitis in pediatric patients are greater than those for adults.

Alternative administrative options can be used for pediatric patients unable to swallow an intact capsule .

In patients with chronic renal impairment, whose creatinine clearance ranged between 10 and 62 mL/min/1.73 m², the disposition of Omax was very similar to that in healthy volunteers, although there was a slight increase in bioavailability. Because urinary excretion is a primary route of excretion of Omax metabolites, their elimination slowed in proportion to the decreased creatinine clearance. No dose reduction is necessary in patients with renal impairment.

Q: Can Prilosec cause high blood pressure?

A: Prilosec (Omax) belongs to a class of drugs called proton pump inhibitors (PPIs). PPIs decrease or block the production of stomach acid. Prilosec is used to treat the symptoms of gastroesophageal reflux disease (GERD), to promote healing of erosive esophagitis, and to treat or prevent ulcers. Common side effects of Prilosec include gas, stomach pain, nausea, vomiting, diarrhea, and headache. According to the prescribing information for Prilosec, elevated blood pressure has been reported by people taking the drug in post-marketing experience. Post-marketing experience is after the drug has been approved by the U.S. Food and Drug Administration (FDA). In post-marketing experience, patients voluntarily report if they have the side effect. Because it is voluntary, not everyone decides to report if they have the side effect. So, it is hard to know how often the side effect occurs. It is also hard to know if it is caused by the drug or by some other reason. This is different than side effects reported during clinical trials before the drug is approved by the FDA. In clinical trials, researchers have tight control over how side effects are reported and can determine whether they are likely related to the drug or not. So, elevated blood pressure may or may not be caused by Prilosec, but it has been reported in patients taking the drug. See your doctor for proper evaluation of your blood pressure. Your doctor is best able to guide your treatment decisions based on your specific circumstances. Sarah Lewis, PharmD

The elimination rate of Omax was somewhat decreased in the elderly, and bioavailability was increased. Omax was 76% bioavailable when a single 40 mg oral dose of Omax (buffered solution) was administered to healthy elderly volunteers, versus 58% in young volunteers given the same dose. Nearly 70% of the dose was recovered in urine as metabolites of Omax and no unchanged drug was detected. The plasma clearance of Omax was 250 mL/min (about half that of young volunteers) and its plasma half-life averaged one hour, about twice that of young healthy volunteers.


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