Omaprin capsules


  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Omaprin?

The active ingredient of Omaprin brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Omaprin is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Omaprin include: trembling; Drowsiness; redness, tenderness, itching, burning, or peeling of the skin; Blurred vision; unusual tiredness or weakness; Body aches or pain.

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Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

  • Severe diarrhea warning: This drug may increase your risk of severe diarrhea. This may be caused by an infection in your intestine caused by the bacteria Clostridium difficile. Call your doctor right away if you have watery diarrhea, stomach pain, and a fever that won’t go away.
  • Bone fractures warning: People who take several doses of a proton pump inhibitor drug, such as Omaprin, every day for a year or longer may have an increased risk of bone fractures. These bone breaks may be more likely to happen in your hip, wrist, or spine. Talk to your doctor about your risk of bone fractures. You should take this drug exactly as prescribed by your doctor. They should prescribe the lowest dose possible for the shortest amount of time needed for your treatment.
  • Low magnesium levels warning: Taking this drug for three months or longer can cause low magnesium levels in your body. Your risk is higher if you take Omaprin for a year or longer. Call your doctor right away if you have symptoms of low magnesium. These can include seizures, abnormal or fast heart rate, jitteriness, jerking movements or shaking, and muscle weakness. They can also include cramps or muscle aches and spasms of your hands, feet, and voice box. Your doctor may check your magnesium levels before and during your treatment with this drug.

Cutaneous lupus erythematosus and systemic lupus erythematosus warning: Omaprin can cause cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). CLE and SLE are autoimmune diseases. Symptoms of CLE can range from a rash on the skin and nose, to a raised, scaly, red or purple rash on certain parts of the body. Symptoms of SLE can include fever, tiredness, weight loss, blood clots, heartburn, and stomach pain. If you have any of these symptoms, call your doctor.

Fundic gland polyps warning: Long-term use (especially over one year) of Omaprin can cause fundic gland polyps. These polyps are growths on the lining of your stomach that can become cancerous. To help prevent these polyps, you should use this drug for as short a time as possible.

Pediatric Patients

For the treatment of GERD and maintenance of healing of erosive esophagitis, the recommended daily dose for pediatric patients 1 to 16 years of age is as follows:

Patient Weight Omaprin Daily Dose 5

On a per kg basis, the doses of Omaprin required to heal erosive esophagitis in pediatric patients are greater than those for adults.

Alternative administrative options can be used for pediatric patients unable to swallow an intact capsule .

Q: Can Prilosec cause a bitter taste in the mouth?

A: Taste perversion is listed as a possible side effect of Prilosec (Omaprin), according to available drug information. Prilosec is a proton pump inhibitor (PPI) and reduces the amount of stomach acid produced by the body. Prilosec is used to treat the symptoms of gastroesophageal reflux disease (GERD) and other medical conditions that result from the production of too much stomach acid. Prilosec is also used to promote healing of erosive esophagitis and may be used in combination with antibiotics to treat gastric ulcers caused by a Helicobacter pylori (H. pylori) infection. The most commonly reported side effects include headache, abdominal pain, nausea, diarrhea and vomiting. Prilosec is typically taken approximately 30 to 60 minutes before a meal. Do not open, chew or crush Prilosec capsules unless instructed to do so by your doctor. Swallow the capsules whole. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

Q: I have been taking Prilosec OTC for several years. What else is available?

A: Your question concerns alternatives to Prilosec OTC (// It seems from your comments that you are no longer satisfied with the results you are getting from Omaprin. Other products in the "Proton Pump Inhibitor" class of antiulcer drugs include AcipHex , Kapidex , Nexium , Prevacid , and Protonix . Even though all these drugs work the same way as Prilosec, there are enough differences among them that many people find relief from at least one of them. Gregory Latham, M.S., RPh

Important Information

Omaprin is not for immediate relief of heartburn symptoms.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Omaprin can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Omaprin may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking Omaprin long term or more than once per day.

Prilosec OTC (over-the-counter) should be taken for no longer than 14 days in a row. Allow at least 4 months to pass before you start another 14-day treatment.

Q: What are the risks of taking Prilosec?

A: Prilosec (Omaprin) is in a class of drugs called proton pump inhibitors. Prescription Prilosec is used to treat ulcers (sores in the lining of the stomach). In combination with other medications, Prilosec is used to eliminate H. pylori (a bacterium that causes ulcers); and thus prevent new ulcers from being formed in patients who have or have had ulcers of the small intestine. Prilosec is also used to treat gastroesophageal reflux disease (GERD) (a condition that is a result of stomach acid flowing backwards into the esophagus -- causing heartburn and damage); to heal erosive esophagitis (inflammation and damage to the esophagus lining); and to treat conditions in which the stomach makes too much acid. Over-the-counter Prilosec is used to treat heartburn that happens frequently -- at least 2 days per week. Prilosec works be reducing acid production in the stomach. The most common side effects with Prilosec are: headache, abdominal pain, nausea, diarrhea, vomiting, and excessive gas. Allergic reaction, which can occur with most medications, is a serious side effect with Prilosec. People should seek emergency medical help if they experience hives; trouble breathing; or swelling of the face, lips, tongue, or throat while taking Prilosec. Prilosec is a benzimidazole-type medication. People who are allergic to Omaprin or other benzimidazole medication, like Albenza (albendazole) or Vermox (mebendazole) should not take Prilosec. Atrophic gastritis has been reported in people treated long-term with Prilosec. Atrophic gastritis is a condition where the normal glands of the stomach are decreased or absent; inflammation is present from attack by the immune system; and stomach cells are damaged. Atrophic gastritis is a precursor for stomach cancer. However, long-term use of proton pump inhibitors has not been proven to cause stomach cancer in humans. Prilosec interacts with certain other medications and vitamins. Because of Prilosec's effect on pH in the stomach, Prilosec may alter the absorption of certain other medications, which may alter blood levels and effectiveness of these medications. Because of Prilosec's effect on liver enzymes, Prilosec may alter the process by which certain other medications are eliminated from the body. Prilosec may increase or decrease the effect of certain other medications. Medications that Prilosec may interact with include: certain blood thinners such as Coumadin (warfarin), Pletal (cilostazol), Plavix (clopidogrel); Valium (diazepam); Antabuse (disulfiram); anti-rejections medications used in people with organ transplants, like Neoral (cyclosporine) and Prograf (tactrolimus); Dilantin (phenytoin), a seizure medication; Nizoral (ketoconazole); Vfend (voriconazole); Omnipen (ampicillin); HIV/AIDS medications like Reyataz (atazanavir), Viracept (nelfinavir), and Invirase (saquinavir); and iron supplements like Feosol. New safety information has become available regarding the use of proton pump inhibitors. The safety information includes a possible increased risk of fractures of the hip, wrist and spine with the use of the medications. Studies have found that the greatest risk of fractures were in people who received high doses of proton pump inhibitors or in people who used the medications for 1 year or more. In general, the risks of taking a medication must be weighed against its health benefits. Derek Dore, PharmD

Q: Is it okay to cut a Prilosec OTC 20 mg tablet in two and take just half a day? The package says not to crush or chew.

A: Prilosec OTC (Omaprin) is used for the treatment of acid reflux. It is in the family of proton pump inhibitors that work by disabling some of the acid producing pumps in the stomach to help relieve the symptoms of acid reflux. The prescribing information on Prilosec OTC states that you should not split the caplet in half because it uses an enteric coating to delay the release of medication until it reaches the small intestine, where it will not be destroyed by the stomach acids. If you break the caplet the coating will not work and this will cause the medication to be ineffective. For more information on Prilosec OTC, click on this link: // For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

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