Nefryl syrup


  • Active Ingredient: Oxybutynin
  • 5 mg, 2.5 mg
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What is Nefryl?

The active ingredient of Nefryl brand is oxybutynin. Oxybutynin reduces muscle spasms of the bladder and urinary tract. Oxybutynin chloride is a white crystalline solid with a molecular weight of 393.95. It is readily soluble in water and acids, but relatively insoluble in alkalis.

Used for

Nefryl is used to treat diseases such as: Dysuria, Hyperhidrosis, Overactive Bladder, Prostatitis, Urinary Incontinence.

Side Effect

Possible side effects of Nefryl include: unusual tiredness or weakness; indigestion; unusual excitement, nervousness, restlessness, or irritability; transdermal gel/jelly, transdermal patch extended release; dryness of the eyes, mouth, nose, or throat; decreased flow of breast milk; belching; heartburn.

How to Buy Nefryl syrup online?

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Nefryl Warnings

You should not use Nefryl if you have untreated or uncontrolled glaucoma, a blockage in your stomach or intestines or if you are unable to urinate.

Tell your doctor if you have been diagnosed with liver or kidney disease, an enlarged prostate, or any other stomach disorder such as GERD, commonly known as reflux disease.

This medicine may cause your eyes to become more sensitive to light. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort. Nefryl may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather.

Nefryl may control your symptoms, but it will not cure your condition. You may notice some improvement in your symptoms within the first two weeks of treatment. However, it may take up to eight weeks to experience the full benefit of Nefryl. You should not stop taking Nefryl without talking to your doctor.

If you are 65 years old or older, talk to your doctor about the risks and benefits of taking Nefryl tablets or syrup. Older adults should not take Nefryl tablets or syrup because they are not as safe and may not be as effective as other medications that can be used to treat the same condition.

You should also inform your doctor if you have kidney disease, liver disease, heart disease, bleeding problems, dementia, glaucoma, trouble swallowing, prostate problems, trouble emptying your bladder, or any kind of digestive problem, such as colitis, constipation, or gastroesophageal reflux disease (GERD).

Nefryl may make you dizzy, drowsy, or cause blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert or not able to see well.

When you first start taking Nefryl, you may see signs of agitation, confusion, sleepiness or unusual drowsiness, or hallucinations. These symptoms should be reported to your doctor immediately.

Nefryl Interactions

If you are taking Nefryl with other drugs such as Dramamine (dimenhydrinate) or Benadryl (diphenhydramine), you will likely experience other side effects. This could include dry mouth, constipation, blurred vision, increased heart rate, and urinary retention.

Combining pramlintide (Symlin) with Nefryl should be avoided. This could cause severely reduce bowel movements.

Nefryl may also delay passage of potassium tablets through the digestive system and result in ulceration or narrowing of the small intestine.

You should tell your doctor about any prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Certain antibiotics, antifungal, antihistamines along with aspirin and other nonsteroidal anti-inflammatory medications can affect how Nefryl is absorbed in your body. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Morphine (MS Contin)
  • Morphine Sulfate XR Liposome (DepoDur)
  • Oxymorphone (Opana)
  • Umeclidinium (Anora Ellipta)

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated, consult your pharmacist for help in choosing a laxative. You should not use alcohol while taking Nefryl.

Michael Stewart, Reviewed by Sid Dajani | Last edited 25 Sep 2018 | Certified by The Information Standard

Nefryl will help to ease urinary symptoms such as urge and frequency in adults and night-time bedwetting in older children.

It may cause you to feel sleepy. If this happens, do not drive and do not use tools or machines while affected.

What is Nefryl, and how does it work (mechanism of action)?

Nefryl is an oral drug that is used for treating urinary bladder spasm. Nefryl has a dual mechanism of action. Contraction of the smooth muscle of the bladder is stimulated by the release of acetylcholine by the nerves within the bladder and the attachment of the acetylcholine to receptors on the surface of the bladder's muscle cells. Nefryl suppresses involuntary contractions of the bladder's smooth muscle (spasms) by blocking the release of acetylcholine. This is referred to as an "anticholinergic effect." Nefryl also directly relaxes the bladder's outer layer of muscle (the detrusor muscle). The FDA approved Nefryl in July 1975.


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Nefryl and call your doctor at once if you have:

  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • severe stomach pain or constipation;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • pain or burning when you urinate; or
  • little or no urinating.

Common side effects may include:

  • dry mouth;
  • dry eyes, blurred vision;
  • mild constipation; or
  • dizziness, drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Ditropan (Nefryl Tablets)

Generic Name: Nefryl (oral) (OX i BUE ti nin)Brand Names: Ditropan XL

Medically reviewed by Sanjai Sinha, MD Last updated on Jan 13, 2019.

Warnings for certain groups

For people with autonomic neuropathy: Nefryl can make your stomach problems worse. Use this drug with caution if you have this condition.

For people with bladder outlet obstruction: Nefryl may increase your risk of not being able to empty your bladder.

For people with stomach problems: Nefryl may cause more stomach problems if you have a history of ulcerative colitis, stomach pain, or reflux.

For people with myasthenia gravis: Nefryl may make your symptoms worse.

For people with dementia: If you’re treating your dementia with a drug called a cholinesterase inhibitor, Nefryl may worsen your dementia symptoms. Your doctor can tell you more.

For pregnant women: Nefryl is a pregnancy category B drug. That means two things:

  1. Research in animals has not shown a risk to the fetus when the mother takes the drug.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used during pregnancy if clearly needed.

For women who are breastfeeding: It isn’t known if Nefryl passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children: The safety and effectiveness of Nefryl in children younger than 6 years haven’t been established.


This medication contains Nefryl. Do not take Ditropan XL if you are allergic to Nefryl or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Why is this medication prescribed?

Nefryl is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) control urgent, frequent, or uncontrolled urination in people who have overactive bladder (a condition in which the bladder muscles have uncontrollable spasms), Nefryl is also used to control bladder muscles in adults and children older than 6 years of age with spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other nervous system conditions that affect the bladder muscles. Nefryl is in a class of medications called anticholinergics/antimuscarinics. It works by relaxing the bladder muscles.

Rated Nefryl for Urinary Incontinence Report

I visit a urologist for incontinence and pain in urinary track, who in a 15 minutes consultation, gave me a pill I could barely walk, I just felt like taking naps and could not function. I tried a different urologist that actually gave a full examination and did some tests, she prescribed Nefryl 5 mg. My symptoms stopped almost immediately, like in 2 days and my life improved a lot. Dry mouth and blurry vision are the symptoms, and I rather have than feel drowzy. I think everyone have different side effect, but so far I am happy with the results.

Important Information

You should not use Nefryl if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.

Before using Nefryl, tell your doctor if you have glaucoma, liver or kidney disease, an enlarged prostate, myasthenia gravis, ulcerative colitis, a blockage in your stomach or intestines, or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Nefryl can decrease perspiration and you may be more prone to heat stroke.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

There are many other medicines that can interact with Nefryl. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Stop using this medication and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating.

Rated Nefryl for Urinary Incontinence Report

I have Multiple Sclerosis and take Ixybutynin due to internal muscle spasms. I take 5 mg three times a day. Side effects I have are dark circles under eyes, fatigue and changing of taste, which made me a Coke drinker even though I was a Pepsi person. I do not mind any of this because I compare it to how I would be without it.

Rated Nefryl for Overactive Bladder (OAB) Report

I have been taking Nefryl for 15 yrs. I started with 5mg. and I am up to 15 mg. For the last year I have been having memory problems. When I was tested by a memory center and they saw the drug I was taking, they said that it can be a side effect of Nefryl. I will now be trying another medication but what they want me to use can cause confusion so I refuse to go on it. I too have acid reflux disease and did not know that this drug could cause problems. I also have had times where I feel like I am having a heart attack but now I know it could have been caused by the Nefryl. I also went to the Dr.'s and had it checked out.

How to use Nefryl patches

  • If you have been prescribed Nefryl patches (brand name Kentera®), you should apply one patch twice-weekly.
  • Apply a patch to a clean, dry area of skin on your tummy (abdomen), hip or bottom. Leave the patch in place for three or four days and then remove it before applying another patch. Apply the new patch to a different area of skin (on your abdomen, hip or bottom). Leave the second patch in place for the rest of the week and then start the next week with a new patch again.

home drugs a-z list Ditropan(Nefryl Tablets) side effects drug center

Ditropan (Nefryl chloride) is an antispasmodic and anticholinergic used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Ditropan is available in generic form. Common side effects of Ditropan include:

Tell your doctor if you experience serious side effects of Ditropan including:

  • decreased sexual activity,
  • difficulty urinating,
  • fast or pounding heartbeat,
  • signs of kidney infection (such as burning/painful/frequent urination, lower back pain, fever),
  • mental/mood changes (such as confusion),
  • swelling of arms/legs/ankles/feet,
  • vision problems (including eye pain),
  • seizures, or
  • stomach or intestinal blockage (such as persistent nausea or vomiting, or prolonged constipation).

The usual adult dose of Ditropan is one 5-mg tablet 2-3 times a day. The maximum recommended adult dose is one 5-mg tablet four times a day. The usual pediatric dose is one 5-mg tablet two times a day. The maximum recommended pediatric dose is one 5-mg tablet three times a day. Doses may be adjusted by your doctor. Some products that may adversely interact with Ditropan include other bladder or urinary medications, glycopyrrolate, flecainide, mepenzolate, thioridazine, HIV /AIDS medicine, antibiotics, antifungal medications, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel medications, or antidepressants. Tell your doctor all medications you are taking. Ditropan should be used only when prescribed by your doctor during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Ditropan (Nefryl chloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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