Mopral capsules

Mopral

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Mopral?

The active ingredient of Mopral brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Mopral is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Mopral include: blisters; bloody or cloudy urine; nausea or vomiting; general feeling of discomfort or illness; mood or mental changes.

How to Buy Mopral capsules online?

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Mopral 40 mg daily was given in combination with clarithromycin 500 mg every 8 hours to healthy adult male subjects. The steady state plasma concentrations of Mopral were increased (Cmax , AUC0-24 , and T1/2 increases of 30%, 89% and 34% respectively) by the concomitant administration of clarithromycin. The observed increases in Mopral plasma concentration were associated with the following pharmacological effects. The mean 24-hour gastric pH value was 5.2 when Mopral was administered alone and 5.7 when co-administered with clarithromycin.

The plasma levels of clarithromycin and 14-hydroxy-clarithromycin were increased by the concomitant administration of Mopral. For clarithromycin, the mean C max was 10% greater, the mean Cmin was 27% greater, and the mean AUC0-8 was 15% greater when clarithromycin was administered with Mopral than when clarithromycin was administered alone. Similar results were seen for 14-hydroxy-clarithromycin, the mean Cmax was 45% greater, the mean C min was 57% greater, and the mean AUC0-8 was 45% greater. Clarithromycin concentrations in the gastric tissue and mucus were also increased by concomitant administration of Mopral.

Table 2 : Clarithromycin Tissue Concentrations 2 hours after Dose 1

For other antiretroviral drugs, such as saquinavir, elevated serum levels have been reported, with an increase in AUC by 82%, in Cmax by 75%, and in Cmin by 106%, following multiple dosing of saquinavir/ritonavir (1000/100 mg) twice daily for 15 days with Mopral 40 mg daily co-administered days 11 to 15. Therefore, clinical and laboratory monitoring for saquinavir toxicity is recommended during concurrent use with PRILOSEC. Dose reduction of saquinavir should be considered from the safety perspective for individual patients.

There are also some antiretroviral drugs of which unchanged serum levels have been reported when given with Mopral.

Q: Can Prilosec cause high blood pressure?

A: Prilosec (Mopral) belongs to a class of drugs called proton pump inhibitors (PPIs). PPIs decrease or block the production of stomach acid. Prilosec is used to treat the symptoms of gastroesophageal reflux disease (GERD), to promote healing of erosive esophagitis, and to treat or prevent ulcers. Common side effects of Prilosec include gas, stomach pain, nausea, vomiting, diarrhea, and headache. According to the prescribing information for Prilosec, elevated blood pressure has been reported by people taking the drug in post-marketing experience. Post-marketing experience is after the drug has been approved by the U.S. Food and Drug Administration (FDA). In post-marketing experience, patients voluntarily report if they have the side effect. Because it is voluntary, not everyone decides to report if they have the side effect. So, it is hard to know how often the side effect occurs. It is also hard to know if it is caused by the drug or by some other reason. This is different than side effects reported during clinical trials before the drug is approved by the FDA. In clinical trials, researchers have tight control over how side effects are reported and can determine whether they are likely related to the drug or not. So, elevated blood pressure may or may not be caused by Prilosec, but it has been reported in patients taking the drug. See your doctor for proper evaluation of your blood pressure. Your doctor is best able to guide your treatment decisions based on your specific circumstances. Sarah Lewis, PharmD

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Low magnesium levels. Using this drug for three months or longer can cause low magnesium levels. Symptoms can include:
    • seizures
    • abnormal or fast heart rate
    • tremors
    • jitteriness
    • muscle weakness
    • dizzinesmethotrs
    • spasms of your hands and feet
    • cramps or muscle aches
    • spasm of your voice box
  • nervousness
  • neuritis (inflammation of a nerve)
  • numbness or tingling in your hands and feet
  • poor muscular coordination
  • changes in menstruation
  • watery stool
  • stomach pain
  • fever that doesn’t go away
  • stomach pain
  • nausea
  • vomiting
  • weight loss
  • Bone fractures
  • flank pain (pain in your side and back)
  • changes in urination
  • rash on the skin and nose
  • raised, red, scaly, red or purple rash on your body
  • fever
  • tiredness
  • weight loss
  • blood clots
  • heartburn
  • Fundic gland polyps (growths on the lining of your stomach that don’t usually cause symptoms)
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Mopral oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Mopral are listed below.

    Q: I take Prilosec for GERD. Is my medication causing me occasional constipation and gas?

    A: Prilosec (Mopral) is classified as a proton pump inhibitor. Prilosec is approved for the treatment of duodenal ulcers, heartburn, symptoms of GERD (gastroesophageal reflux disease), erosive esophagitis, hypersecretory conditions, and for the treatment of H. pylori. According to medical references, flatulence (excessive gas) and constipation are possible side effects reported by studied patients taking Prilosec. The incidence that flatulence was reported at is 3 percent of patients. Constipation is reported at an incidence of 2 percent. If you think that you are experiencing a side effect from your medication, talk with your physician. Do not stop taking or change the dose of your medication without first talking to your physician. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jen Marsico, RPh

    How long will I take it for?

    If you bought the medicine yourself from a pharmacy, tell your doctor if you feel no better after taking Mopral for 2 weeks.

    They may want to do tests to find out what's causing your symptoms or change you to a different medicine.

    Depending on your illness or the reason you're taking Mopral, you may only need it for a few weeks or months.

    Sometimes you might need to take it for longer, even for many years.

    Some people don't need to take Mopral every day and take it only when they have symptoms.

    Once you feel better (often after a few days or weeks), you can stop taking it.

    But taking Mopral in this way isn't suitable for everyone. Talk to your doctor about what's best for you.

    Q: I have been taking Prilosec OTC for several years. What else is available?

    A: Your question concerns alternatives to Prilosec OTC (//www.everydayhealth.com/drugs/prilosec) It seems from your comments that you are no longer satisfied with the results you are getting from Mopral. Other products in the "Proton Pump Inhibitor" class of antiulcer drugs include AcipHex , Kapidex , Nexium , Prevacid , and Protonix . Even though all these drugs work the same way as Prilosec, there are enough differences among them that many people find relief from at least one of them. Gregory Latham, M.S., RPh


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