Which drugs or supplements interact with Macromicina?
Macromicina interacts with several drugs because it reduces the activity of liver enzymes that breakdown many drugs. This leads to increased blood levels and side effects from the affected drugs. Examples of such interactions include
Macromicina increases blood levels of sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), vardenafil (Levitra), theophylline and carbamazepine (Tegretol), thereby increasing side effects of these drugs.
Ritonavir (Norvir) and atazanavir (Reyataz) increase blood levels of Macromicina while efavirenz (Sustiva), nevirapine (Viramune), rifampin, decrease blood levels of Macromicina.
Itraconazole (Sporanox) and saquinavir (Invirase) may increase blood levels of Macromicina while Macromicina increases blood levels or both drugs.
The occurrence of abnormal heart beats may increase when Macromicina is combined with drugs that affect heart beat (for example, amiodarone , quinidine , and disopyramide).
The concomitant use of BIAXIN and oral hypoglycemic agents and/or insulin can result in significant hypoglycemia. With certain hypoglycemic drugs such as nateglinide, pioglitazone, repaglinide and rosiglitazone, inhibition of CYP3A enzyme by Macromicina may be involved and could cause hypoglycemia when used concomitantly. Careful monitoring of glucose is recommended .
Rated Macromicina for Streptococcus Agalactiae (group B Streptococci) Report
I was diagnosed with strep throat and instead of putting me on amoxicillin they put me on Macromicina. The instructions were 2 500mg tablets per day so I did the mistake of taking 1000mg all at once. This caused an extreme anxiety attack, (i have GAD and it was unlike any anxiety i’ve ever had), severe gas and stomach issues, the worst diarrhea ever, and ultimately the worst side effects i’ve ever experienced from any drug. do not take this unless it’s your last resource. the absolute worst.
Changes in laboratory values with possible clinical significance in patients taking BIAXIN and omeprazole in four randomized double-blind trials in 945 patients are as follows:
Hepatic: elevated direct bilirubin 1 A numerically higher number of primary outcome events in patients randomized to receive Macromicina was observed with a hazard ratio of 1.06 (95% confidence interval 0.98 to 1.14). However, at follow-up 10 years post-treatment, there were 866 (40%) deaths in the Macromicina group and 815 (37%) deaths in the placebo group that represented a hazard ratio for all-cause mortality of 1.10 (95% confidence interval 1.00 to 1.21). The difference in the number of deaths emerged after one year or more after the end of treatment.
The cause of the difference in all-cause mortality has not been established. Other epidemiologic studies evaluating this risk have shown variable results .
What Happens if I Take too Much Macromicina and Overdose?
If you suspect an overdose, you should contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (800) 222-1222.
Interactions that increase your risk of side effects
Taking Macromicina with certain medications may cause more side effects. Examples of these drugs include:
- Benzodiazepines, such as triazolam and midazolam. If you take these drugs together, you may feel more sedated and drowsy.
- Insulin and certain oral diabetes drugs, such as nateglinide, pioglitazone, repaglinide, and rosiglitazone. You may have a significant decrease in your blood sugar levels. You may need to monitor your blood sugar levels closely while taking these drugs together.
- Warfarin. You may have more bleeding. Your doctor will monitor you closely if you take these drugs together.
- Drugs used to treat cholesterol (statins), such as atorvastatin and pravastatin. Taking these drugs together may cause muscle problems. Your doctor may change the dose of your statin if you need to take these drugs together.
- Quinidine and disopyramide. Taking these drugs together may cause serious abnormal heart rhythms. Your doctor may monitor your heart rhythm and the levels of quinidine or disopyramide in your body.
- Blood pressure drugs (calcium channel blockers), such as verapamil, amlodipine, diltiazem, and nifedipine. Taking these drugs together may cause a drop in blood pressure and kidney problems.
- Theophylline. Your doctor may monitor your theophylline blood levels.
- Carbamazepine. Your doctor may monitor your carbamazepine blood levels.
- Digoxin. Your doctor may monitor your digoxin blood levels.
- Quetiapine. Taking this drug with Macromicina may cause sleepiness, low blood pressure upon standing, confusion, and heart rhythm problems. Your doctor should monitor you closely with this combination.
When a single dose of colchicine 0.6 mg was administered with Macromicina 250 mg BID for 7 days, the colchicine Cmax increased 197% and the AUC0-∞ increased 239% compared to administration of colchicine alone.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
The following in vitro mutagenicity tests have been conducted with Macromicina:
- Salmonella/Mammalian Microsomes Test
- Bacterial Induced Mutation Frequency Test
- In Vitro Chromosome Aberration Test
- Rat Hepatocyte DNA Synthesis Assay
- Mouse Lymphoma Assay
- Mouse Dominant Lethal Study
- Mouse Micronucleus Test
All tests had negative results except the in vitro chromosome aberration test which was positive in one test and negative in another. In addition, a bacterial reverse-mutation test (Ames test) has been performed on Macromicina metabolites with negative results.
Median survival time from trial entry (trial 1) was 249 days at the 500 mg twice daily dose compared to 215 days with the 1000 mg twice daily dose. However, during the first 12 weeks of therapy, there were 2 deaths in 53 patients in the 500 mg twice daily group versus 13 deaths in 51 patients in the 1000 mg twice daily group. The reason for this apparent mortality difference is not known. Survival in the two groups was similar beyond 12 weeks. The median survival times for these dosages were similar to recent historical controls with MAC when treated with combination therapies. 2
Median survival time from entry in trial 2 was 199 days for the 500 mg twice a day dose and 179 days for the 1000 mg twice a day dose. During the first four weeks of therapy, while patients were maintained on their originally assigned dose, there were 11 deaths in 255 patients taking 500 mg twice daily and 18 deaths in 214 patients taking 1000 mg twice daily.
Dosage-Ranging Monotherapy Trials In Pediatric AIDS Patients With MAC
Trial 4 was a pediatric trial of 3.75 mg/kg, 7.5 mg/kg, and 15 mg/kg of BIAXIN twice daily in patients with CDC-defined AIDS and CD4 counts less than 100 cells/mcL. The trial enrolled 25 patients between the ages of 1 to 20. The trial evaluated the same endpoints as in the adult trials 1 and 2. Results with the 7.5 mg/kg twice daily dose in the pediatric trial were comparable to those for the 500 mg twice daily regimen in the adult trials.
Combination Therapy In AIDS Patients With Disseminated MAC
Trial 5 compared the safety and efficacy of BIAXIN in combination with ethambutol versus BIAXIN in combination with ethambutol and clofazimine for the treatment of disseminated MAC (dMAC) infection. This 24-week trial enrolled 106 patients with AIDS and dMAC, with 55 patients randomized to receive BIAXIN and ethambutol, and 51 patients randomized to receive Macromicina, ethambutol, and clofazime. Baseline characteristics between treatment arms were similar with the exception of median CFU counts being at least 1 log higher in the BIAXIN, ethambutol, and clofazime arm.
Compared to prior experience with Macromicina monotherapy, the two-drug regimen of Macromicina and ethambutol extended the time to microbiologic relapse, largely through suppressing the emergence of Macromicina resistant strains. However, the addition of clofazimine to the regimen added no additional microbiologic or clinical benefit. Tolerability of both multidrug regimens was comparable with the most common adverse events being gastrointestinal in nature. Patients receiving the clofazimine-containing regimen had reduced survival rates; however, their baseline mycobacterial colony counts were higher. The results of this trial support the addition of ethambutol to Macromicina for the treatment of initial dMAC infections but do not support adding clofazimine as a third agent.
What other drugs will affect Macromicina?
When you start or stop taking Macromicina, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
Macromicina can cause a serious heart problem, especially if you use certain medicines at the same time, such as antibiotics, antifungal medicine, antidepressants, anti-malaria medicine, asthma inhalers, antipsychotic medicine, cancer medicine, certain HIV/AIDS medicine, heart or blood pressure medicine, or medicine to prevent vomiting.
Many drugs can interact with Macromicina, and some drugs should not be used together. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
- Chlamydophila pneumoniae
- Helicobacter pylori
- Mycobacterium avium complex (MAC) consisting of M. avium and M. intracellulare
- Mycoplasma pneumoniae
At least 90 percent of the microorganisms listed below exhibit in vitro minimum inhibitory concentrations (MICs) less than or equal to the Macromicina susceptible MIC breakpoint for organisms of similar type to those shown in Table 11. However, the efficacy of Macromicina in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials.
Life-threatening and fatal drug interactions have been reported in patients treated with BIAXIN and colchicine. Macromicina is a strong CYP3A4 inhibitor and this interaction may occur while using both drugs at their recommended doses. If co-administration of BIAXIN and colchicine is necessary in patients with normal renal and hepatic function, reduce the dose of colchicine. Monitor patients for clinical symptoms of colchicine toxicity. Concomitant administration of BIAXIN and colchicine is contraindicated in patients with renal or hepatic impairment .
Why it's used
Macromicina is used to prevent and treat certain infections caused by bacteria.
Macromicina may be used with other drugs (ethambutol, rifampin, amoxicillin, lansoprazole, omeprazole, or bismuth) to treat stomach ulcers or mycobacterial infections.
What Is Macromicina (Biaxin)?
Macromicina is the generic form of the brand-name prescription drug Biaxin, an antibiotic used to treat bacterial infections.
Macromicina is often used for pneumonia, bronchitis, and infections of the ears, sinuses, skin and throat. It is also used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection, which is a type of lung infection that often occurs in patients with HIV.
The drug may also be used in combination with other medicines to eliminate H. pylori - a bacterium that causes ulcers. It is sometimes used to treat other types of infections including Lyme disease, cryptosporidiosis, cat scratch disease, Legionnaires' disease, and pertussis (whooping cough). It is occasionally used to prevent heart infections in people having dental or other procedures.
Macromicina is in a class of medications known as macrolide antibiotics. It works by stopping the growth of bacteria. Like all antibiotics, it cannot kill viruses that cause colds, flu or other viral infections.
Researchers from the Japanese drug company Taisho Pharmaceutical developed Macromicina in the 1970s. In 1985, Taisho partnered with the American company Abbott Laboratories for the international rights, and Abbott gained FDA approval for Biaxin in October, 1991. The drug went generic in the United States in 2005.
You should continue to take Macromicina until your prescription is finished, even if you feel better. Stopping this medication too soon or skipping doses can prevent your infection from being treated completely, and the bacteria may become resistant to antibiotics.
Dictionary Entries near Macromicina
Cite this Entry
“Macromicina.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Macromicina. Accessed 27 December 2019.
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By Julie Marks | Medically Reviewed by Sherry Brooks, MD
Latest Update: 2014-09-03 Copyright © 2014 Everyday Health Media, LLC
Should I Avoid Any Food, Drink or Activity While Taking Macromicina?
Unless your doctor tells you otherwise, you can continue your normal diet and activities while taking Macromicina.
Interactions that can make your drugs less effective
When certain drugs are used with Macromicina, they may not work as well. This is because the amount of these drugs in your body may be decreased. An example of these drugs includes zidovudine. You should take Macromicina and zidovudine at least 2 hours apart.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Getting the most from your treatment
- Some people develop thrush (redness and itchiness in the mouth or vagina) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice about how to treat it.
- This antibiotic may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
- If you are taking a 'statin' medicine for high cholesterol your doctor may advise you to stop taking the statin whilst being treated with Macromicina. Ask your doctor or pharmacist if you are unsure.
- If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking Macromicina.
- If you buy any medicines, check with a pharmacist that they are suitable to take with this antibiotic.
- If you still feel unwell after completing your course of the antibiotic, make another appointment to see your doctor.