Will my dose go up or down?
Sometimes your doctor will increase your dose of Losectil if it isn't working well enough.
Depending on the reason you take Losectil, you may take a higher dose to begin with, usually for a month or two.
After this, your doctor may recommend that you take a lower dose.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Low magnesium levels. Using this drug for three months or longer can cause low magnesium levels. Symptoms can include:
- abnormal or fast heart rate
- muscle weakness
- spasms of your hands and feet
- cramps or muscle aches
- spasm of your voice box
- neuritis (inflammation of a nerve)
- numbness or tingling in your hands and feet
- poor muscular coordination
- changes in menstruation
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Losectil oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Losectil are listed below.
How to use Losectil
If your doctor has prescribed this medication for you, read the Patient Information Leaflet if available from your pharmacist before you start taking Losectil and each time you get a refill. If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication.
Take this medication by mouth as directed, usually once daily before a meal. The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on weight. Do not increase your dose or take this drug more often than directed. If you have any questions, ask your doctor or pharmacist.
Do not crush, break, or chew delayed release tablets. Doing so can release all of the drug at once, increasing the risk of side effects.
If you are using the disintegrating delayed release tablets, use dry hands to handle the tablets. Place the tablet on your tongue and let it dissolve. After the tablet has dissolved, it can be swallowed with or without water. The tablets can also be swallowed whole with water.
If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take Losectil at least 30 minutes before sucralfate.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better. If you are self-treating with the over-the-counter product, do not take it for more than 14 days unless directed by your doctor.
Tell your doctor if your condition lasts or gets worse. If you are self-treating, tell your doctor if your heartburn lasts after 14 days or if you need to use this medication more than once every 4 months. The risk of side effects goes up over time. Ask your doctor how long you should take this medication. If you think you may have a serious medical problem, get medical help right away.
People of Asian descent. Your doctor may give you a lower dose of this medication, especially if you’re taking it for erosive esophagitis.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Losectil oral capsule is used for short-term treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD). It’s used for long-term treatment of erosive esophagitis and pathological hypersecretory conditions. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: Your acid reflux, heartburn, or ulcer symptoms may not improve. They may even get worse.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms can include:
- blurred vision
- fast heart rate
- dry mouth
If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: You should have decreased pain and acid reflux symptoms.
As with all medications, the costs of Losectil can vary. To find current prices for your area, check out GoodRx.com.
Keep these considerations in mind if your doctor prescribes Losectil oral capsule for you.
There are no adequate and well-controlled studies with PRILOSEC in pregnant women. Available epidemiologic data fail to demonstrate an increased risk of major congenital malformations or other adverse pregnancy outcomes with first trimester Losectil use.
Teratogenicity was not observed in animal reproduction studies with administration of oral esLosectil magnesium in rats and rabbits with doses about 68 times and 42 times, respectively, an oral human dose of 40 mg (based on a body surface area basis for a 60 kg person). However, changes in bone morphology were observed in offspring of rats dosed through most of pregnancy and lactation at doses equal to or greater than approximately 34 times an oral human dose of 40 mg (see Animal Data). Because of the observed effect at high doses of esLosectil magnesium on developing bone in rat studies, PRILOSEC should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
That fire in your chest might be the least of your problems.
Raise your hand if you want to physically rip your throat out of your neck after eating a spicy meal—or, honestly, after eating anything at all. I feel you; heartburn is no joke. Luckily, there's a drug for that: Losectil.
Omepra-what? You've probably heard of it as Prilosec or Zegerid—it's one of the most popular treatments for chronic heartburn. You can buy it over the counter any time you're having after-dinner indigestion, or if you've got a serious case of the burn, your doctor can prescribe you a stronger dosage.
The medicine's a type of drug called a "proton-pump inhibitor." Losectil works by blocking gastric acid secretion in your stomach which reduces heartburn, says Shilpa Ravella, M.D., a gastroenterologist and assistant professor of medicine at Columbia University Medical Center.
It can also be used to treat ulcers and to help patients with tumors that result in high levels of gastric acid secretion, she adds. Losectil can be used for a short period like a few weeks, or for a longer time, including lifetime use.
But whether you're just popping an OTC pill to help you get through a rough patch or you need to stay on it long-term, there are some side effects of Losectil you should definitely know about.
Q: I have taken Prilosec for 14 days. How long will it take to restore my gastric acid?
A: According to the prescribing information for Prilosec (Losectil), once the drug is discontinued, gastric acid secretion returns gradually over three to five days. Prilosec is categorized as a proton pump inhibitor (PPI) and reduces the amount of stomach acid produced by the body. Prilosec is used to treat the symptoms of gastroesophageal reflux disease (GERD) and other medical conditions that result from too much stomach acid. Prilosec is also used to promote healing of erosive esophagitis and may be used in combination with antibiotics to treat gastric ulcers caused by a Helicobacter pylori (H. pylori) infection. The most commonly reported side effects associated with treatment with Prilosec include headache, abdominal pain, nausea, diarrhea and vomiting. In most cases, Losectil is taken approximately 30 to 60 minutes before a meal. Take Prilosec exactly as directed by your healthcare provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
By Lynn Marks | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-01-09 Copyright © 2014 Everyday Health Media, LLC
The effectiveness of PRILOSEC for the treatment of nonerosive GERD in pediatric patients 1 to 16 years of age is based in part on data obtained from 125 pediatric patients in two uncontrolled Phase III studies .
The first study enrolled 12 pediatric patients 1 to 2 years of age with a history of clinically diagnosed GERD. Patients were administered a single dose of Losectil (0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg) for 8 weeks as an open capsule in 8.4% sodium bicarbonate solution. Seventy-five percent (9/12) of the patients had vomiting/regurgitation episodes decreased from baseline by at least 50%.
The second study enrolled 113 pediatric patients 2 to 16 years of age with a history of symptoms suggestive of nonerosive GERD. Patients were administered a single dose of Losectil (10 mg or 20 mg, based on body weight) for 4 weeks either as an intact capsule or as an open capsule in applesauce. Successful response was defined as no moderate or severe episodes of either pain-related symptoms or vomiting/regurgitation during the last 4 days of treatment. Results showed success rates of 60% (9/15; 10 mg Losectil) and 59% (58/98; 20 mg Losectil), respectively.
Losectil (Prilosec, Zeger >
- What is Losectil, and how does it work (mechanism of action)?
- What brand names are available for Losectil?
- Is Losectil available as a generic drug?
- Do I need a prescription for Losectil?
- What are the side effects of Losectil?
- What is the dosage for Losectil?
- Which drugs or supplements interact with Losectil?
- Is Losectil safe to take if I'm pregnant or breastfeeding?
- What else should I know about Losectil?
Losectil dose (20 mg to 360 mg)
The exact dose of Losectil that you use on a daily basis might impact whether you experience certain side effects, as well as the severities of the side effects that you experience. In most cases, it is believed that the greater the dose of Losectil administered, the more significantly the medication will suppress stomach acid production via blockade of the H+/K+-ATPase enzyme.
Because larger doses of Losectil modulate physiology of the user to a greater extent than smaller doses, side effects tend to be more prevalent and intense among high-dose users. On the other hand, because smaller doses of Losectil won’t alter physiology as significantly, side effects are less likely to occur – and if they do occur – they might be less severe than at high doses.
Medical documentation suggests that Losectil is typically administered at doses between 20 mg and 40 mg per day in adults with gastroesophageal conditions. Assuming you’re using a low or standard dose of Losectil (20 mg to 40 mg per day), the likelihood that you’ll experience unbearable side effects is very low.
That said, some patients may require up to 360 mg of Losectil per day to manage medical symptoms. If you’re taking very high doses of Losectil, you’ll be more likely to end up with intense side effects and harsh adverse reactions due to a larger quantity of the medication modulating physiologic processes (e.g. stomach acid production, nutrient absorption, gut bacteria concentrations, etc.).
Losectil 40 mg daily was given in combination with clarithromycin 500 mg every 8 hours to healthy adult male subjects. The steady state plasma concentrations of Losectil were increased (Cmax , AUC0-24 , and T1/2 increases of 30%, 89% and 34% respectively) by the concomitant administration of clarithromycin. The observed increases in Losectil plasma concentration were associated with the following pharmacological effects. The mean 24-hour gastric pH value was 5.2 when Losectil was administered alone and 5.7 when co-administered with clarithromycin.
The plasma levels of clarithromycin and 14-hydroxy-clarithromycin were increased by the concomitant administration of Losectil. For clarithromycin, the mean C max was 10% greater, the mean Cmin was 27% greater, and the mean AUC0-8 was 15% greater when clarithromycin was administered with Losectil than when clarithromycin was administered alone. Similar results were seen for 14-hydroxy-clarithromycin, the mean Cmax was 45% greater, the mean C min was 57% greater, and the mean AUC0-8 was 45% greater. Clarithromycin concentrations in the gastric tissue and mucus were also increased by concomitant administration of Losectil.
Table 2 : Clarithromycin Tissue Concentrations 2 hours after Dose 1
What if I take too much?
It's very unlikely that taking 1 or 2 extra doses by accident will cause any problems.
But you should check with your doctor if you have taken too much and have any of these symptoms:
- flushed skin
- feeling sweaty
- a fast heartbeat
- feeling sleepy
- blurred vision
- feeling confused or agitated
Most people who take Losectil don't have any side effects. If you do get a side effect, it's usually mild and will go away when you stop taking Losectil.