Losec capsules

Losec

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Losec?

The active ingredient of Losec brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Losec is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Losec include: heartburn; sores, ulcers, or white spots on the lips, in the mouth, or on the genitals; Drowsiness; skin rash or itching; dryness of the mouth.

How to Buy Losec capsules online?

To get Losec online - simply click on the "Buy Now" button from the top and follow on to our shop. Payment and Order takes a few minutes, and all steps are obvious. We do not take a medical prescription and also we have many procedures of payment. With all the details of rapid delivery and confidentiality, then you may read on the applicable pages on the hyperlinks in the top menu.

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Have you experienced Losec side effects?

If you’re currently taking Losec – or are a former Losec user, report the side effects that you experienced – in the comments section. In your comment, mention the side effects that were harshest or most noticeable, and assign a numeric rating to each of those side effects (on a scale from 1 to 10, with “1” being minimal severity and “10” maximal severity).

To ensure that people reading this article are able to understand your situation, consider providing extra details such as: your Losec dose (e.g. 20 mg per day); the format you use (e.g. oral pills); the total duration of your treatment (e.g. 1 month); and concurrently-administered medications.

If you use other substances with Losec, have you investigated whether the side effects you’re experiencing might be due to an interaction effect and/or solely caused by the other substance(s)? In your experience, do the therapeutic effects of Losec outweigh the side effects? If you endured unwanted side effects during treatment, were there any strategies that you found helpful for reducing them?

In summary, while Losec is considered a safe and effective proton-pump inhibitor (PPI), not everyone tolerates it perfectly. If you find yourself unable to tolerate Losec, inform your doctor as soon as possible and consider alternative treatment options.

Concurrent substance use (Interactions)

If you’re using substances with Losec, it is important to consider that concurrently administered agents might: interfere with the action of Losec; induce interaction effects; exacerbate Losec side effects (via synergistic mechanisms); or trigger side effects that have nothing to do with Losec (yet that you might mistakenly attribute to Losec).

For example, when Losec is administered along with clarithromycin and amoxicillin (as part of “triple therapy”) to treat H. pylori infection, risk of side effects like taste perversion and tongue discoloration significantly increase (compared to Losec monotherapy). The increase in side effect risk among persons using Losec as part of triple therapy is probably due to synergistic physiologic actions simultaneously exerted by the trio.

The most significant major drug interaction with Losec is clopiodgrel. Because Losec inhibits enzymes CYP2C19 and CYP3A4, and clopidogrel requires these enzymes for its metabolism, patients using clopidogrel may not receive therapeutic quantities of clopidogrel metabolites necessary to reduce the risk of cerebrovascular events like heart attack and stroke, possibly leading to cerebrovascular complications.

Other substances might also interact with Losec pharmacokinetically via CYP450 enzymes (e.g. CYP3A4, CYP2C19, CYP2D6), leading to increased or decreased efficacy. For example, Losec’s inhibition of CYP3A4 might substantially increase concentrations of benzodiazepines (most of which are metabolized by this enzyme), leading to more potent benzodiazepine effects (and side effects).

If you’re using medications that require CYP450 metabolism, you may be at increased risk of pharmacokinetically-mediated interaction effects. Additionally, concurrent use of medications that require stomach acid for absorption (e.g. ketoconazole) might not work as well. Oppoistely, acid-labile medications (e.g. erythromycin) might be absorbed more extensively when used with Losec – leading to more significant effects (and side effects).

Have a medical doctor evaluate the concurrent medications that you’re using with Losec to ensure that you don’t experience pharmacokinetically-mediated interactions and/or synergistic side effects. Moreover, understand that some concurrently-administered substances may cause side effects that you’re wrongfully assuming are from Losec – or side effects that overlap with and exacerbate the side effects of Losec.

For other antiretroviral drugs, such as saquinavir, elevated serum levels have been reported, with an increase in AUC by 82%, in Cmax by 75%, and in Cmin by 106%, following multiple dosing of saquinavir/ritonavir (1000/100 mg) twice daily for 15 days with Losec 40 mg daily co-administered days 11 to 15. Therefore, clinical and laboratory monitoring for saquinavir toxicity is recommended during concurrent use with PRILOSEC. Dose reduction of saquinavir should be considered from the safety perspective for individual patients.

There are also some antiretroviral drugs of which unchanged serum levels have been reported when given with Losec.

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Call a doctor straight away if you have:

  • joint pain along with a red skin rash, especially in parts of your body exposed to the sun, such as your arms, cheeks and nose - these can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you have been taking Losec for a long time
  • yellow skin, dark pee and tiredness - these can be signs of liver problems

Atrophic Gastritis

Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Losec.

Nursing Mothers

Losec is present in human milk. Losec concentrations were measured in breast milk of a woman following oral administration of 20 mg. The peak concentration of Losec in breast milk was less than 7% of the peak serum concentration. This concentration would correspond to 0.004 mg of Losec in 200 mL of milk. Caution should be exercised when PRILOSEC is administered to a nursing woman.

Q: I suffer from excessive belching. Could this be because of the Prilosec I take every day, which my doctor has prescribed?

A: Prilosec OTC (Losec) is commonly prescribed to treat ulcers, reflux disease, and heartburn associated with GERD. It's also used for the long-term treatment of pathological hypersecretory conditions. In clinical studies, the most common side effects reported with Prilosec include headache, abdominal pain, nausea, vomiting, gas, and diarrhea. This is not a complete list of the side effects associated with Prilosec. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Other causes of bloating and gas pains include the following: swallowing too much air, smoking, certain foods and beverages, prescription and nonprescription medications, nutritional supplements, dietary supplements, constipation, GERD, and certain medical conditions. Adopting certain lifestyle modifications can help alleviate bloating and gas symptoms. Try to chew food slowly; avoid drinking from a straw; avoid chewing gum or sucking on hard candy; avoid foods that are difficult to digest, such as cabbage, brussel sprouts, grapes, beans, or lentils; avoid foods, beverages, and candy containing sorbitol and fructose; avoid foods, beverages, medications, dietary supplements, and nutritional supplements containing the milk protein lactose if you are lactose intolerant; and don't smoke. Consuelo Worley, RPh, MS Pharm

Interactions With Diagnostic Investigations For Neuroendocrine Tumors

Serum chromogranin A (CgA) levels increase secondary to drug-induced decreases in gastric acidity. The increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumors. Healthcare providers should temporarily stop Losec treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are high. If serial tests are performed (e.g. for monitoring), the same commercial laboratory should be used for testing, as reference ranges between tests may vary.

Pediatric Patients

For the treatment of GERD and maintenance of healing of erosive esophagitis, the recommended daily dose for pediatric patients 1 to 16 years of age is as follows:

Patient Weight Losec Daily Dose 5

On a per kg basis, the doses of Losec required to heal erosive esophagitis in pediatric patients are greater than those for adults.

Alternative administrative options can be used for pediatric patients unable to swallow an intact capsule .

Q: I take Prilosec for GERD. Is my medication causing me occasional constipation and gas?

A: Prilosec (Losec) is classified as a proton pump inhibitor. Prilosec is approved for the treatment of duodenal ulcers, heartburn, symptoms of GERD (gastroesophageal reflux disease), erosive esophagitis, hypersecretory conditions, and for the treatment of H. pylori. According to medical references, flatulence (excessive gas) and constipation are possible side effects reported by studied patients taking Prilosec. The incidence that flatulence was reported at is 3 percent of patients. Constipation is reported at an incidence of 2 percent. If you think that you are experiencing a side effect from your medication, talk with your physician. Do not stop taking or change the dose of your medication without first talking to your physician. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jen Marsico, RPh

Natural Losec alternatives

Using these remedies, along with following a healthy diet, can help up say goodbye to Losec and ward off stomach disorders caused by acid.

COMMON BRAND(S): Prilosec OTC

GENERIC NAME(S): Losec

Losec is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Losec belongs to a class of drugs known as proton pump inhibitors (PPIs).

If you are self-treating with this medication, over-the-counter Losec products are used to treat frequent heartburn (occurring 2 or more days a week). Since it may take 1 to 4 days to have full effect, these products do not relieve heartburn right away.

For over-the-counter products, carefully read the package instructions to make sure the product is right for you. Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar brand names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

Q: I have read recently that Prilosec is not good to be taken on a regular basis. Is it safe to take occasionally? I know years ago there was a correlation between Prilosec and cancer. Now they are talking about it again.

A: Prilosec (Losec) is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, and gastric reflux. Prilosec is now available over the counter. Patients who take Prilosec over the counter should not take it for longer than two weeks consistently without consulting their health care provider. This is due to the fact that if you have symptoms that last longer than two weeks, you may have a more serious condition that would need to be evaluated and treated by a physician. Long-term use of PPIs is generally considered safe under the direction of a doctor. There is some talk that long term use of PPI's could cause some problems, such as decreased immunity and osteoporosis, but this is yet to be proven. It is always best to avoid taking medication you do not need, but occasional use of Prilosec is likely to be safe, and long term use under the direction of a physician would also likely be safe for most patients. Please see the following Everyday Health link for more information on Prilosec. //www.everydayhealth.com/drugs/prilosec. Laura Cable, PharmD

Four randomized, double-blind, multi-center studies (4, 5, 6, and 7) evaluated PRILOSEC 40 mg once daily plus clarithromycin 500 mg three times daily for 14 days, followed by PRILOSEC 20 mg once daily, (Studies 4, 5, and 7) or by PRILOSEC 40 mg once daily (Study 6) for an additional 14 days in patients with active duodenal ulcer associated with H. pylori. Studies 4 and 5 were conducted in the U.S. and Canada and enrolled 242 and 256 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 219 patients in Study 4 and 228 patients in Study 5. These studies compared the combination regimen to PRILOSEC and clarithromycin monotherapies. Studies 6 and 7 were conducted in Europe and enrolled 154 and 215 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 148 patients in Study 6 and 208 patients in Study 7. These studies compared the combination regimen with Losec monotherapy. The results for the efficacy analyses for these studies are described below. H. pylori eradication was defined as no positive test (culture or histology) at 4 weeks following the end of treatment, and two negative tests were required to be considered eradicated of H. pylori. In the per-protocol analysis, the following patients were excluded: dropouts, patients with missing H. pylori tests post-treatment, and patients that were not assessed for H. pylori eradication because they were found to have an ulcer at the end of treatment.

The combination of Losec and clarithromycin was effective in eradicating H. pylori.

Table 6 : H. pylori Eradication Rates (Per-Protocol Analysis at 4 to 6 Weeks) % of Patients Cured PRILOSEC + Clarithromycin PRILOSEC Clarithromycin U.S. Studies Study 4 74 †‡ 0 31 (n = 53) (n = 54) (n = 42) Study 5 64 †‡ 0 39 (n = 61) (n = 59) (n = 44) Non U.S. Studies Study 6 83 ‡ 1 N/A (n = 60) (n = 74) Study 7 74 ‡ 1 N/A (n = 86) (n = 90) †Statistically significantly higher than clarithromycin monotherapy (p

Ulcer healing was not significantly different when clarithromycin was added to Losec therapy compared with Losec therapy alone.

The combination of Losec and clarithromycin was effective in eradicating H. pylori and reduced duodenal ulcer recurrence.

Table 7 : Duodenal Ulcer Recurrence Rates by H. pylori Eradication Status % of Patients with Ulcer Recurrence

Antacids and Losec

Antacids neutralize hydrochloric acids in the stomach which leads to instant effect that treats the symptoms of acid.

On the other hand, Losec starts to kick in after four days of its use, which is why its considered to be a long-term treatment.

It’s important to mention that while you can buy antacids over the counter, Losec is a prescription drug that has to be issued by a doctor.

I am a woman in her late 30's. I have been taking Losec for 2 years now. I was instructed to take it by a ENT doctor for healing of my esophagus due to acid erosion(scarring) caused by silent reflux. (Diagnosed via endoscopy) I have noticed a decrease in hunger, lack of "growling" of the stomach. Has anyone else experienced this? Is long term use of Losec really safe?

This discussion is related to Worried about throat cancer!.


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