What is the most important information I should know about Lexapram:
Lexapram is a prescription medication that is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. Lexapram is available as 5mg and 10mg scored tablets. The usual dose for dogs and cats is 0.1-0.2mg/pound every 6-8 hours. Always follow the dosage instructions provided by your veterinarian. Lexapram is not for use in animals allergic to it. Call your veterinarian immediately if your pet exhibits uncontrollable movements or muscle spasms of the legs, lips, jaw, tongue, face or other body part, agitation, jitteriness, shortness of breath or insomnia. Lexapram may cause drowsiness.
What other drugs will affect Lexapram?
Using Lexapram with other drugs that make you drowsy can worsen this effect. Ask your doctor before you take opioid pain medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines. Many drugs can affect Lexapram, especially:
cyclosporine (Gengraf, Neoral, Sandimmune);
digoxin (digitalis, Lanoxin);
levodopa (Larodopa, Atamet, Parcopa, Sinemet);
tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
blood pressure medications;
bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);
an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.
This list is not complete and there are many other drugs that can interact with Lexapram. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Q: I am on Reglan for my bowel problems. How long can I take it?
A: Reglan (Lexapram) is routinely prescribed for bowel problems. Ideally, the bowel problems subside with treatment, dietary changes are sometimes employed and eventually the Reglan is tapered off and the patient may have to repeat short courses of therapy every once in a while until the bowel problems have rectified. On occasion, the physician may feel that ongoing treatment with Reglan is warranted as long as there are no side effects or interactions with other medication. I have evaluated patients in long-term care facilities that have been on Reglan for several years, it is well tolerated in most groups. For more information, please visit //www.everydayhealth.com/drugs/reglan. Matt Curley, PharmD
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Treatment with Lexapram can cause tardive dyskinesia, a serious movement disorder that is often irreversible. The risk of developing tardive dyskinesia increases with duration of treatment and total cumulative dose.
Lexapram therapy should be discontinued in patients who develop signs or symptoms of tardive dyskinesia. There is no known treatment for tardive dyskinesia. In some patients, symptoms may lessen or resolve after Lexapram treatment is stopped.
Treatment with Lexapram for longer than 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing tardive dyskinesia.
Interactions that increase your risk of side effects from Lexapram
Taking Lexapram with certain medications raises your risk of side effects from Lexapram. Examples of these drugs include:
- Sedatives, hypnotics, narcotics, antihistamines, and tranquilizers. These include:
Taking any of these drugs with Lexapram may increase drowsiness.
- Monoamine oxidase inhibitors (MAOIs). These include:
Taking these drugs with Lexapram may increase your blood pressure.
What should I discuss with my veterinarian before giving Lexapram to my pet:
Tell your veterinarian if your pet has kidney disease, diabetes, high blood pressure or recent stomach surgery. Inform your veterinarian if your pet is pregnant or lactating.
What is the dosage for Lexapram?
The usual dose of Lexapram for treating GERD is 10-15 mg four times daily, 30 minutes before each meal.
Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime.