Klarcin tablets

Klarcin

  • Active Ingredient: Clarithromycin
  • 500 mg, 250 mg
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What is Klarcin?

The active ingredient of Klarcin brand is clarithromycin. Clarithromycin is a macrolide antibiotic. Clarithromycin fights bacteria in your body. Clarithromycin is a white to off-white crystalline powder. It is soluble in acetone, slightly soluble in methanol, ethanol, and acetonitrile, and practically insoluble in water. Clarithromycin tablets, USP are intended for oral administration and contain 250 mg or 500 mg of Clarithromycin, USP. In addition, each Clarithromycin tablet contains the following inactive ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, talc, and titanium dioxide.

Used for

Klarcin is used to treat diseases such as: Bacterial Endocarditis Prevention, Bronchitis, Dental Abscess, Follicular Lymphoma, Helicobacter Pylori Infection, Legionella Pneumonia, Mycobacterium avium-intracellulare, Prophylaxis, Mycobacterium avium-intracellulare, Treatment, Mycoplasma Pneumonia, Nongonococcal Urethritis, Otitis Media, Pertussis, Pertussis Prophylaxis, Pharyngitis, Pneumonia, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, Strep Throat, Tonsillitis/Pharyngitis, Toxoplasmosis, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Klarcin include: continuing ringing or buzzing or other unexplained noise in the ears; dark urine; blurred vision; severe stomach cramps and pain; Alterations of sense of smell; slurred speech; lower back or side pain.

How to Buy Klarcin tablets online?

To buy Klarcin online - simply click on the "Buy Now" button in the top and follow on to our shop. Payment and Order takes a couple of minutes, and all steps are evident. We don't take a medical prescription plus we have many procedures of payment. Considering each detail of fast shipping and confidentiality, you can read on the relevant pages on the hyperlinks in the top menu.

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Interactions that can make your drugs less effective

When certain drugs are used with Klarcin, they may not work as well. This is because the amount of these drugs in your body may be decreased. An example of these drugs includes zidovudine. You should take Klarcin and zidovudine at least 2 hours apart.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Mechanism of Liver Injury

The cause of the idiosyncratic liver injury due to Klarcin is unknown, but the rapidity of onset and prompt recurrence upon rechallenge suggests hypersensitivity. Klarcin is extensively metabolized by the microsomal cytochrome P450 system and is a potent inhibitor of CYP 3A4, for which reason it can cause serious drug-drug interactions with agents that are metabolized by CYP 3A4 such as siapride, terfenadine, ergotamine, colchicine, amlodipine, diltiazem and many statins and benzodiazepines. Thus, in some situations, Klarcin may lead to liver injury from a concurrent medication because of a decrease in its metabolism and increased blood levels.

Geriatric Use

In a steady-state study in which healthy elderly subjects (65 years to 81 years of age) were given 500 mg of BIAXIN every 12 hours, the maximum serum concentrations and area under the curves of Klarcin and 14-OH Klarcin were increased compared to those achieved in healthy young adults. These changes in pharmacokinetics parallel known age-related decreases in renal function. In clinical trials, elderly patients did not have an increased incidence of adverse reactions when compared to younger patients. Consider dosage adjustment in elderly patients with severe renal impairment. Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients .

Most reports of acute kidney injury with calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, amlodipine, diltiazem, nifedipine) involved elderly patients 65 years of age or older .

Especially in elderly patients, there have been reports of colchicine toxicity with concomitant use of Klarcin and colchicine, some of which occurred in patients with renal insufficiency. Deaths have been reported in some patients .

Summary

Klarcin (Biaxin, Biaxin XL) is an antibiotic drug prescribed for the treatment of a large variety of bacterium. Klarcin is used to treat infections of the middle ear, tonsils, throat, larynx, bronchioles, lungs, and skin. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.

Generic Name: Klarcin (kla RITH roe MYE sin)Brand Names: Biaxin, Biaxin XL

Medically reviewed by Sanjai Sinha, MD Last updated on Nov 4, 2019.

Klarcin has been shown to be active against most of the isolates of the following microorganisms both in vitro and in clinical infections .


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