Interactions that can make your drugs less effective
When certain drugs are used with Klarcin, they may not work as well. This is because the amount of these drugs in your body may be decreased. An example of these drugs includes zidovudine. You should take Klarcin and zidovudine at least 2 hours apart.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Mechanism of Liver Injury
The cause of the idiosyncratic liver injury due to Klarcin is unknown, but the rapidity of onset and prompt recurrence upon rechallenge suggests hypersensitivity. Klarcin is extensively metabolized by the microsomal cytochrome P450 system and is a potent inhibitor of CYP 3A4, for which reason it can cause serious drug-drug interactions with agents that are metabolized by CYP 3A4 such as siapride, terfenadine, ergotamine, colchicine, amlodipine, diltiazem and many statins and benzodiazepines. Thus, in some situations, Klarcin may lead to liver injury from a concurrent medication because of a decrease in its metabolism and increased blood levels.
In a steady-state study in which healthy elderly subjects (65 years to 81 years of age) were given 500 mg of BIAXIN every 12 hours, the maximum serum concentrations and area under the curves of Klarcin and 14-OH Klarcin were increased compared to those achieved in healthy young adults. These changes in pharmacokinetics parallel known age-related decreases in renal function. In clinical trials, elderly patients did not have an increased incidence of adverse reactions when compared to younger patients. Consider dosage adjustment in elderly patients with severe renal impairment. Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients .
Most reports of acute kidney injury with calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, amlodipine, diltiazem, nifedipine) involved elderly patients 65 years of age or older .
Especially in elderly patients, there have been reports of colchicine toxicity with concomitant use of Klarcin and colchicine, some of which occurred in patients with renal insufficiency. Deaths have been reported in some patients .
Klarcin (Biaxin, Biaxin XL) is an antibiotic drug prescribed for the treatment of a large variety of bacterium. Klarcin is used to treat infections of the middle ear, tonsils, throat, larynx, bronchioles, lungs, and skin. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
Generic Name: Klarcin (kla RITH roe MYE sin)Brand Names: Biaxin, Biaxin XL
Medically reviewed by Sanjai Sinha, MD Last updated on Nov 4, 2019.
Klarcin has been shown to be active against most of the isolates of the following microorganisms both in vitro and in clinical infections .